5-(2-Methyl-pyridin-3-yloxy)-pyrazine-2-carboxylic acid methyl ester | 300554-35-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-(2-Methyl-pyridin-3-yloxy)-pyrazine-2-carboxylic acid methyl ester
• 英文别名: Methyl 5-(2-methylpyridin-3-yl)oxypyrazine-2-carboxylate；methyl 5-(2-methylpyridin-3-yl)oxypyrazine-2-carboxylate
• CAS: 300554-35-2
• 化学式: C₁₂H₁₁N₃O₃
• 分子量: 245.238
• InChiKey: OVSHJRURMRSHMS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  74.2
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  5-(2-Methyl-pyridin-3-yloxy)-pyrazine-2-carboxylic acid methyl ester 在 盐酸 、 一水合肼 、 sodium nitrite 作用下， 以 甲醇 为溶剂， 反应 4.5h， 生成 5-(2-Methyl-pyridin-3-yloxy)-pyrazine-2-carbonyl azide
  参考文献：
  名称：

  1-[2-[(Heteroaryloxy)heteroaryl]carbamoyl]indolines: novel and selective 5-HT2C receptor inverse agonists with potential as antidepressant/Anxiolytic agents

  摘要：

  Bisaryl ethers have been identified with excellent 5-HT2C affinity and selectivity over both 5-HT2A and 5-HT2B receptors. Compounds such as 11, 27 and 38 have potent oral activity in a centrally mediated pharmacodynamic model of 5-HT2C function and their potential as novel non-sedating anxiolytic and antidepressants is under investigation. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00364-4
• 作为产物：
  描述：

  3-羟基-2-甲基吡啶 、 5-氯吡嗪-2-羧酸甲酯 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 以94%的产率得到5-(2-Methyl-pyridin-3-yloxy)-pyrazine-2-carboxylic acid methyl ester
  参考文献：
  名称：

  1-[2-[(Heteroaryloxy)heteroaryl]carbamoyl]indolines: novel and selective 5-HT2C receptor inverse agonists with potential as antidepressant/Anxiolytic agents

  摘要：

  Bisaryl ethers have been identified with excellent 5-HT2C affinity and selectivity over both 5-HT2A and 5-HT2B receptors. Compounds such as 11, 27 and 38 have potent oral activity in a centrally mediated pharmacodynamic model of 5-HT2C function and their potential as novel non-sedating anxiolytic and antidepressants is under investigation. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00364-4

文献信息

• 1-[2-[(Heteroaryloxy)heteroaryl]carbamoyl]indolines: novel and selective 5-HT2C receptor inverse agonists with potential as antidepressant/Anxiolytic agents
  作者：Steven M. Bromidge、Steven Dabbs、Susannah Davies、D.Malcolm Duckworth、Ian T. Forbes、Graham E. Jones、Jerome Jones、Frank D. King、Damian V. Saunders、Thomas P. Blackburn、Vicky Holland、Guy A. Kennett、Sean Lightowler、Derek N. Middlemiss、Graham J. Riley、Brenda Trail、Martyn D. Wood

  DOI：10.1016/s0960-894x(00)00364-4

  日期：2000.8

  Bisaryl ethers have been identified with excellent 5-HT2C affinity and selectivity over both 5-HT2A and 5-HT2B receptors. Compounds such as 11, 27 and 38 have potent oral activity in a centrally mediated pharmacodynamic model of 5-HT2C function and their potential as novel non-sedating anxiolytic and antidepressants is under investigation. (C) 2000 Elsevier Science Ltd. All rights reserved.