5-(2-Methyl-pyridin-3-yloxy)-pyrazine-2-carbonyl azide | 300554-36-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-(2-Methyl-pyridin-3-yloxy)-pyrazine-2-carbonyl azide
• CAS: 300554-36-3
• 化学式: C₁₁H₈N₆O₂
• 分子量: 256.224
• InChiKey: AKCPSKKUEWOIMR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.42
• 重原子数：
  19.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  113.73
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  5-甲基-6-三氟甲基吲哚啉 、 5-(2-Methyl-pyridin-3-yloxy)-pyrazine-2-carbonyl azide 以 甲苯 为溶剂， 反应 1.0h， 以63%的产率得到5-Methyl-6-trifluoromethyl-2,3-dihydro-indole-1-carboxylic acid [5-(2-methyl-pyridin-3-yloxy)-pyrazin-2-yl]-amide
  参考文献：
  名称：

  1-[2-[(Heteroaryloxy)heteroaryl]carbamoyl]indolines: novel and selective 5-HT2C receptor inverse agonists with potential as antidepressant/Anxiolytic agents

  摘要：

  Bisaryl ethers have been identified with excellent 5-HT2C affinity and selectivity over both 5-HT2A and 5-HT2B receptors. Compounds such as 11, 27 and 38 have potent oral activity in a centrally mediated pharmacodynamic model of 5-HT2C function and their potential as novel non-sedating anxiolytic and antidepressants is under investigation. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00364-4
• 作为产物：
  描述：

  5-(2-Methyl-pyridin-3-yloxy)-pyrazine-2-carboxylic acid methyl ester 在 盐酸 、 一水合肼 、 sodium nitrite 作用下， 以 甲醇 为溶剂， 反应 4.5h， 生成 5-(2-Methyl-pyridin-3-yloxy)-pyrazine-2-carbonyl azide
  参考文献：
  名称：

  1-[2-[(Heteroaryloxy)heteroaryl]carbamoyl]indolines: novel and selective 5-HT2C receptor inverse agonists with potential as antidepressant/Anxiolytic agents

  摘要：

  Bisaryl ethers have been identified with excellent 5-HT2C affinity and selectivity over both 5-HT2A and 5-HT2B receptors. Compounds such as 11, 27 and 38 have potent oral activity in a centrally mediated pharmacodynamic model of 5-HT2C function and their potential as novel non-sedating anxiolytic and antidepressants is under investigation. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00364-4