(R)-<(p-Trifluoromethyl)phenyl>glycine | 144789-73-1

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-<(p-Trifluoromethyl)phenyl>glycine
• 英文别名: D-α-(4-Trifluoromethylphenyl)glycine；(2R)-2-azaniumyl-2-[4-(trifluoromethyl)phenyl]acetate
• CAS: 144789-73-1
• 化学式: C₉H₈F₃NO₂
• 分子量: 219.163
• InChiKey: FANMQHUKZBBELZ-SSDOTTSWSA-N

物化性质

• 沸点：
  297.2±40.0 °C(Predicted)
• 密度：
  1.415±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  ethyl 2-methyl-5-oxo-4-[4-(trifluoromethyl)phenyl]-1,3-oxazole-4-carboxylate 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 50.5h， 生成 (R)-<(p-Trifluoromethyl)phenyl>glycine
  参考文献：
  名称：

  Morgan, Jacqueline; Pinhey, John T.; Sherry, Christopher J., Journal of the Chemical Society. Perkin transactions I, 1997, # 5, p. 613 - 619

  摘要：

  DOI：

文献信息

• [9,10-dimethoxy-3-(2-methylpropyl)-1H,2H,3H,4H,6H,7H,11BH-pyrido-[2,1-a]isoquinolin-2-yl]methanol and compounds, compositions and methods relating thereto
  申请人：Neurocrine Biosciences, Inc.

  公开号：US11053242B2

  公开（公告）日：2021-07-06

  Compounds having a structure of formula (I), including stereoisomers and pharmaceutically acceptable salts and solvates thereof: wherein R1 is as defined herein. Such compounds are inhibitors of the vesicular monoamine transporter 2 (VMAT2) and have utility for treating, for example, hyperkinetic disorders. Also disclosed are compositions containing these compounds in combination with a pharmaceutically acceptable carrier or diluent, as well as methods relating to the use in a subject in need thereof.

  具有式 (I) 结构的化合物，包括立体异构体及其药学上可接受的盐和溶液： 其中 R1 如本文所定义。这类化合物是囊泡单胺转运体 2（VMAT2）的抑制剂，可用于治疗过度运动障碍等疾病。还公开了含有这些化合物的组合物与药学上可接受的载体或稀释剂的组合物，以及有关在有需要的受试者中使用的方法。
• Synthesis of optically active arylglycines by photolysis of optically active (.beta.-hydroxyamino) carbene-chromium(0) complexes
  作者：Jean Michel Vernier、Louis S. Hegedus、David B. Miller

  DOI：10.1021/jo00051a044

  日期：1992.12

  Photolysis of [(amino)(aryl)carbene]chromium complexes having the optically active amino alcohol (1R,2S-(-)- or (1S,2R)-(+)-2-amino-1,2-diphenylethanol as the amino group produced aryl-substituted oxazinones in good yield with reasonable diastereoselectivity. Facile separation of diastereoisomers followed by mild reductive cleavage produced several arylglycines, having either electron-donating or withdrawing groups on the aromatic ring, in good overall yield and with excellent enantiomeric excess.
• [9,10-DIMETHOXY-3-(2-METHYLPROPYL)-1H,2H,3H,4H,6H,7H,11BH-PYRIDO-[2,1-A]ISOQUINOLIN-2-YL]METHANOL AND COMPOUNDS, COMPOSITIONS AND METHODS RELATING THERETO
  申请人：Neurocrine Biosciences, Inc.

  公开号：US20160289226A1

  公开（公告）日：2016-10-06

  Compounds having a structure of formula (I), including stereoisomers and pharmaceutically acceptable salts and solvates thereof: wherein R 1 is as defined herein. Such compounds are inhibitors of the vesicular monoamine transporter 2 (VMAT2) and have utility for treating, for example, hyperkinetic disorders. Also disclosed are compositions containing these compounds in combination with a pharmaceutically acceptable carrier or diluent, as well as methods relating to the use in a subject in need thereof.
• US9714246B2
  申请人：——

  公开号：US9714246B2

  公开（公告）日：2017-07-25
• US9988382B2
  申请人：——

  公开号：US9988382B2

  公开（公告）日：2018-06-05