1-(1,1-dimethoxyethyl)cyclohex-1-ene | 83822-64-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(1,1-dimethoxyethyl)cyclohex-1-ene
• 英文别名: 1-cyclohex-1-enyl-ethanone-dimethylacetal；1-Cyclohex-1-enyl-aethanon-dimethylacetal；1-(1,1-Dimethoxyethyl)cyclohexene
• CAS: 83822-64-4
• 化学式: C₁₀H₁₈O₂
• 分子量: 170.252
• InChiKey: NFCAMFCAVHXMQS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(1,1-dimethoxyethyl)cyclohex-1-ene 在 potassium hydrogensulfate 作用下， 生成 (1-cyclohex-1-enyl-vinyl)-methyl ether
  参考文献：
  名称：

  Physicians' Attitudes Toward Litigation and Defensive Practice: Development of a Scale

  摘要：

  The authors' threefold purpose in this article was to (a) propose a model of the relationship between the emotional aspects of physicians' attitudes to medical errors (eg, fear of litigation) and their functional consequences (eg, tendency to defensive practice); (b) develop a measure of some of these attitudes; and (c) provide empirical support for some of the relationships in the model. Medical students and physicians responded to a questionnaire concerning their attitudes toward uncertainty and medical error The dependent variables were two dimensions of attitudes to uncertainty ("reluctance to disclose uncertainty" and "stress from uncertainty") and four dimensions of attitudes to medical error ("fear of litigation," "support for self-regulation," "tendency to defensive practice," and "self-disclosure of errors "). Stress from uncertainty correlated with fear of malpractice litigation and defensive practice. They concluded that interventions that aim to increase physicians' tolerance of uncertainty may also reduce their fear of malpractice litigation and their tendency to defensive practice.

  DOI：

  10.1080/08964280109595771
• 作为产物：
  描述：

  炔环己醇 在 吡啶 、 三氟化硼乙醚 、 mercury(II) oxide 、 三氯氧磷 作用下， 生成 1-(1,1-dimethoxyethyl)cyclohex-1-ene
  参考文献：
  名称：

  Physicians' Attitudes Toward Litigation and Defensive Practice: Development of a Scale

  摘要：

  The authors' threefold purpose in this article was to (a) propose a model of the relationship between the emotional aspects of physicians' attitudes to medical errors (eg, fear of litigation) and their functional consequences (eg, tendency to defensive practice); (b) develop a measure of some of these attitudes; and (c) provide empirical support for some of the relationships in the model. Medical students and physicians responded to a questionnaire concerning their attitudes toward uncertainty and medical error The dependent variables were two dimensions of attitudes to uncertainty ("reluctance to disclose uncertainty" and "stress from uncertainty") and four dimensions of attitudes to medical error ("fear of litigation," "support for self-regulation," "tendency to defensive practice," and "self-disclosure of errors "). Stress from uncertainty correlated with fear of malpractice litigation and defensive practice. They concluded that interventions that aim to increase physicians' tolerance of uncertainty may also reduce their fear of malpractice litigation and their tendency to defensive practice.

  DOI：

  10.1080/08964280109595771

文献信息

• High-Pressure-Promoted Uncatalyzed Ketalization of Ketones and Oxy-Michael/Ketalization of Conjugated Enones
  作者：Hiyoshizo Kotsuki、Koji Kumamoto、Yoshiyasu Ichikawa

  DOI：10.1055/s-2005-872229

  日期：——

  A new practical method for ketalization or oxy-Michael/ ketalization was developed using the high-pressure-promoted condensation of ketones or α,β-unsaturated ketones with alcohols in the presence of trialkyl orthoformates as water scavengers.

  在原甲酸三烷基酯作为水清除剂的情况下，使用酮或α,β-不饱和酮与醇的高压促进缩合，开发了一种用于缩酮化或氧-迈克尔/缩酮化的实用新方法。
• Highly Acidic Conjugate‐Base‐Stabilized Carboxylic Acids Catalyze Enantioselective oxa‐Pictet–Spengler Reactions with Ketals
  作者：Zhengbo Zhu、Minami Odagi、Chenfei Zhao、Khalil A. Abboud、Helmi Ulrika Kirm、Jaan Saame、Märt Lõkov、Ivo Leito、Daniel Seidel

  DOI：10.1002/anie.201912677

  日期：2020.1.27

  accessible chiral carboxylic acid catalyst exerts control over asymmetric cyclizations of acyclic ketone-derived trisubstituted oxocarbenium ions, thereby providing access to highly enantioenriched dihydropyran products containing a tetrasubstituted stereogenic center. The high acidity of the carboxylic acid catalyst, which exceeds that of the well-known chiral phosphoric acid catalyst TRIP, is largely

  无环酮衍生的氧碳鎓离子作为中间体参与许多可提供有价值产物的反应，然而，到目前为止，它们仍在努力进行不对称催化。我们报告说，一种容易获得的手性羧酸催化剂对无环酮衍生的三取代氧碳鎓离子的不对称环化产生控制，从而提供了对高对映体富集的含有四取代立体异构中心的二氢吡喃产品的访问。羧酸催化剂的高酸度超过了众所周知的手性磷酸催化剂TRIP的酸度，很大程度上是由于通过分子内阴离子键合到硫脲位点上的羧酸盐共轭碱的稳定化而产生的。
• DAVTYAN, S. ZH.;CHOBANYAN, ZH. A.;BADANYAN, SH. O., ARM. XIM. ZH., 1983, 36, N 8, 508-514
  作者：DAVTYAN, S. ZH.、CHOBANYAN, ZH. A.、BADANYAN, SH. O.

  DOI：——

  日期：——