6-benzyloxycarbonyl-1-ethoxycarbonyl-4-oxo-4H-quinoline | 332366-42-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-benzyloxycarbonyl-1-ethoxycarbonyl-4-oxo-4H-quinoline
• 英文别名: 6-O-benzyl 1-O-ethyl 4-oxoquinoline-1,6-dicarboxylate
• CAS: 332366-42-4
• 化学式: C₂₀H₁₇NO₅
• 分子量: 351.359
• InChiKey: PPBPVCLNJVYRBB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  72.9
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  6-benzyloxycarbonyl-1-ethoxycarbonyl-4-oxo-4H-quinoline 在 2,6-二甲基吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 生成 6-benzyloxycarbonyl-1-ethoxycarbonyl-2-(2-propenyl)-4-tri-iso-propylsilyloxy-2H-quinoline
  参考文献：
  名称：

  Efficient allylation of 4-silyloxyquinolinium triflates and other positively charged heteroaromatic systems

  摘要：

  The regioselective allylation of 4-silyloxyquinolinium triflates with allyltri-n-butyltin has been performed to give 2-allyl-4-silyloxy-1,2-dihydroquinolines with excellent yields. Similiar results have been obtained with 4-silyloxy-l-benzopyrylium triflates and 4-silyloxy-1-benzothiopyrylium triflates. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(00)01066-8
• 作为产物：
  描述：

  2,2-dimethyl-5-(4-benzyloxycarbonyl-phenylamino-methylene)-[1,3]dioxan-4,6-dione 在 sodium hydride 作用下， 以 四氢呋喃 、 二苯醚 为溶剂， 反应 3.0h， 生成 6-benzyloxycarbonyl-1-ethoxycarbonyl-4-oxo-4H-quinoline
  参考文献：
  名称：

  Efficient allylation of 4-silyloxyquinolinium triflates and other positively charged heteroaromatic systems

  摘要：

  The regioselective allylation of 4-silyloxyquinolinium triflates with allyltri-n-butyltin has been performed to give 2-allyl-4-silyloxy-1,2-dihydroquinolines with excellent yields. Similiar results have been obtained with 4-silyloxy-l-benzopyrylium triflates and 4-silyloxy-1-benzothiopyrylium triflates. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(00)01066-8

文献信息

• Efficient allylation of 4-silyloxyquinolinium triflates and other positively charged heteroaromatic systems
  作者：Uwe Beifuss、Ursula Schniske、Gerald Feder

  DOI：10.1016/s0040-4020(00)01066-8

  日期：2001.2

  The regioselective allylation of 4-silyloxyquinolinium triflates with allyltri-n-butyltin has been performed to give 2-allyl-4-silyloxy-1,2-dihydroquinolines with excellent yields. Similiar results have been obtained with 4-silyloxy-l-benzopyrylium triflates and 4-silyloxy-1-benzothiopyrylium triflates. (C) 2001 Elsevier Science Ltd. All rights reserved.