5-Ethylpyrido[4,3-b]indole | 1028067-99-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 5-Ethylpyrido[4,3-b]indole
• CAS: 1028067-99-3
• 化学式: C₁₃H₁₂N₂
• 分子量: 196.252
• InChiKey: KHJVXHPPMMSRIE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  17.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  5-Ethylpyrido[4,3-b]indole 在 氯磺酸 作用下， 以 乙腈 为溶剂， 反应 12.0h， 生成
  参考文献：
  名称：

  Design, synthesis, and quantitative structure–activity relationship of cytotoxic γ-carboline derivatives

  摘要：

  Three series of gamma-carboline derivatives were designed and synthesized. All the compounds were tested for their cytotoxic activities in vitro against five human tumor cell lines (A549, SGC, HCT116, MCF-7, K562) and one multi-drug resistant subline (K562R). Most compounds showed moderate to potent cytotoxic activities against the tested cell lines. Sulfonate 11f exhibited more potent cytotoxic activities against almost all of the tested cells in comparison with the positive control, taxol, with IC50 values ranging from 0.15 to 4.5 mu M. The structure-activity relationships were discussed and a statistically reliable QSAR model (r(2) = 0.936, q(2) = 0.581) was established by the CoMFA analysis performed using the cytotoxic data against K562 cell line as a template. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.03.037
• 作为产物：
  描述：

  5H-吡啶并[4,3-b]吲哚 、 碘乙烷 在 sodium hydride 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 0.5h， 以67.3%的产率得到5-Ethylpyrido[4,3-b]indole
  参考文献：
  名称：

  γ-Carboline derivatives with anti-bovine viral diarrhea virus (BVDV) activity

  摘要：

  Based on anti-viral screening of our heteroaromatics derived from thalidomide, the gamma-carboline skeleton has been identified as a superior scaffold structure for compounds with potent anti-bovine viral diarrhea virus (BVDV) activity. Structural development studies led to a potent anti-viral agent, SK5M (5-methyl-gamma-carboline), with the EC50 of 0.26 mu M. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.01.052

文献信息

• COMPOSITION OF MATTER FOR USE IN ORGANIC LIGHT-EMITTING DIODES
  申请人：Kyulux, Inc.

  公开号：US20190233412A1

  公开（公告）日：2019-08-01

  The present disclosure relates to compounds capable of emitting delayed fluorescence and uses of these compounds in organic light-emitting diodes.

  本公开涉及能够发射延迟荧光的化合物以及这些化合物在有机发光二极管中的应用。
• CONDENSED CYCLIC COMPOUND, COMPOSITION INCLUDING THE CONDENSED CYCLIC COMPOUND, ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE CONDENSED CYCLIC COMPOUND, AND METHOD OF MANUFACTURING THE ORGANIC LIGHT-EMITTING DEVICE
  申请人：SAMSUNG ELECTRONICS CO., LTD.

  公开号：US20170174705A1

  公开（公告）日：2017-06-22

  A condensed cyclic compound represented by Formula (1): wherein, in Formula (1), groups and variables are the same as described in the specification.

  一种由式(1)表示的紧凑的环状化合物：其中，在式(1)中，基团和变量与规范中描述的相同。
• Composition of matter for use in organic light-emitting diodes
  申请人：Kyulux, Inc.

  公开号：US10644249B2

  公开（公告）日：2020-05-05

  The present disclosure relates to compounds of Formula (I), (II), (III), (IV), or (V): as compounds capable of emitting delayed fluorescence, and uses of the compounds in organic light-emitting diodes.

  本公开涉及式 (I)、(II)、(III)、(IV) 或 (V) 的化合物： 作为能够发出延迟荧光的化合物，以及这些化合物在有机发光二极管中的用途。
• [EN] C-MYC PROTEIN INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF<br/>[FR] INHIBITEUR DE PROTÉINE C-MYC, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION<br/>[ZH] 一种c-Myc蛋白抑制剂及其制备方法和用途
  申请人：SUZHOU KINTOR PHARMACEUTICALS INC

  公开号：WO2021004391A1

  公开（公告）日：2021-01-14

  涉及一类c-Myc蛋白抑制剂及其制备方法和用途，所述c-Myc蛋白抑制剂可选择性的抑制c-Myc蛋白，因此，可用于c-Myc蛋白失调的相关疾病，如癌症、心脑血管疾病、病毒感染相关疾病等的预防和治疗。
• Design, synthesis, and biological evaluation of novel γ-carboline ketones as anticancer agents
  作者：Jing Chen、Tao Liu、Rui Wu、Jianshu Lou、Xiaowu Dong、Qiaojun He、Bo Yang、Yongzhou Hu

  DOI：10.1016/j.ejmech.2011.01.057

  日期：2011.4

  A series of novel gamma-carboline ketones were designed, synthesized and evaluated for their cytotoxic activity in vitro against six human cancer cell lines (A549, SGC, HCT116, MCF-7, K562 and K562R). Biological evaluation revealed that almost all of the new compounds displayed moderate to potent cytotoxic activities against the tested cells. Among them, seven of the fourteen new compounds show more potent cytotoxic activities against K562R cell line than that of the positive control, taxol. Primary mechanism research on the most potent compound 6f indicated that it was a potent tubulin polymerization inhibitor, with IC(50) value of 4.3 mu M, equivalent to that of CA-4, and arresting cell cycle in G(2)/M phase. (c) 2011 Elsevier Masson SAS. All rights reserved.