approach for the azasugars 1,4-dideoxy-1,4-imino-d-allitol, l-allitol, and 1,4-dideoxy-1,4-imino-d-talitol is described for different olefin compounds I derived from (R)-2,3-O-isopropylidine glyceraldehyde, l-ascorbic acid, and d-isoascorbic acid by using vinyl Grignard addition, allylation, RCM, and dihydroxylation as the key steps.
对于不同的烯烃化合物I,描述了对氮杂糖1,4-二脱氧-1,4-亚
氨基-d-烯丙糖醇,1-
烯丙醇和1,4-二脱氧-1,4-亚
氨基-d-塔罗糖醇的立体选择性方法。通过将
乙烯基格氏试剂加成,烯丙基化,RCM和二羟基化作为关键步骤,衍生自(R)-2,3- O-异丙基
甘油醛,1-
抗坏血酸和d-
异抗坏血酸。