2-(4-(prop-2-yn-1-yloxy)phenyl)-naphtho[1,2-d]oxazole | 1469283-54-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(4-(prop-2-yn-1-yloxy)phenyl)-naphtho[1,2-d]oxazole
• 英文别名: 2-(4-(Prop-2-yn-1-yloxy)phenyl)naphtho[1,2-d]oxazole；2-(4-prop-2-ynoxyphenyl)benzo[e][1,3]benzoxazole
• CAS: 1469283-54-2
• 化学式: C₂₀H₁₃NO₂
• 分子量: 299.329
• InChiKey: GDMSITMNVMSMRN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  35.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  p-叠氮甲苯 、 2-(4-(prop-2-yn-1-yloxy)phenyl)-naphtho[1,2-d]oxazole 在 copper(l) iodide 作用下， 以 四氢呋喃 为溶剂， 反应 6.0h， 以97%的产率得到2-(4-((1-p-tolyl-1H-1,2,3-triazol-4yl)methoxy)-phenyl)naptho[1,2-d]oxazole
  参考文献：
  名称：

  Synthesis and characterization of 2-(4-((1-alkyl or aryl-1H-1,2,3-triazol-4-yl)methoxy)phenyl)naphtho[1,2-d]oxazoles for protein tyrosine phosphatase 1B inhibitory activity

  摘要：

  2-(4-((1-Alkyl/aryl-1H-1,2,3-triazol-4-yl)methoxy)phenyl)naphtho[1,2-d] were prepared and evaluated as protein tyrosine phosphatase 1B (PTP1B) inhibitors. In this study, two new compounds with potent PTP1B inhibitory activity were identified.

  DOI：

  10.1007/s00044-013-0784-0
• 作为产物：
  描述：

  2-(2-hydroxynaphthalen-1-yl)(4-hydroxyphenyl) 在 乙酰氧肟酸 、 硫酸 、 potassium carbonate 作用下， 以 丙酮 、 乙腈 为溶剂， 80.0 ℃ 、172.37 kPa 条件下， 反应 4.17h， 生成 2-(4-(prop-2-yn-1-yloxy)phenyl)-naphtho[1,2-d]oxazole
  参考文献：
  名称：

  Synthesis and characterization of 2-(4-((1-alkyl or aryl-1H-1,2,3-triazol-4-yl)methoxy)phenyl)naphtho[1,2-d]oxazoles for protein tyrosine phosphatase 1B inhibitory activity

  摘要：

  2-(4-((1-Alkyl/aryl-1H-1,2,3-triazol-4-yl)methoxy)phenyl)naphtho[1,2-d] were prepared and evaluated as protein tyrosine phosphatase 1B (PTP1B) inhibitors. In this study, two new compounds with potent PTP1B inhibitory activity were identified.

  DOI：

  10.1007/s00044-013-0784-0

文献信息

• Synthesis and characterization of 2-(4-((1-alkyl or aryl-1H-1,2,3-triazol-4-yl)methoxy)phenyl)naphtho[1,2-d]oxazoles for protein tyrosine phosphatase 1B inhibitory activity
  作者：Sridhar Madabhushi、Narsaiah Chinthala、Abhinav Kanwal、Gagandeep Kaur、Sanjay K. Banerjee

  DOI：10.1007/s00044-013-0784-0

  日期：2014.4

  2-(4-((1-Alkyl/aryl-1H-1,2,3-triazol-4-yl)methoxy)phenyl)naphtho[1,2-d] were prepared and evaluated as protein tyrosine phosphatase 1B (PTP1B) inhibitors. In this study, two new compounds with potent PTP1B inhibitory activity were identified.