2,9-吖啶二胺 | 23043-62-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 2,9-吖啶二胺
• 英文名称: 2,9-diamino-acridine
• 英文别名: 2,9-diaminoacridine；2,9-Diaminoacridin；acridine-2,9-diyldiamine；Acridin-2,9-diyldiamin；3,5-Diaminoacridin；acridine-2,9-diamine
• CAS: 23043-62-1
• 化学式: C₁₃H₁₁N₃
• 分子量: 209.25
• InChiKey: FCXMXTMQASDIDU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  64.9
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  2,9-吖啶二胺 在 sodium nitrate 、 sodium azide 作用下， 生成 9-amino-2-azidoacridine
  参考文献：
  名称：

  Identification of an acridine photoaffinity probe for trypanocidal action

  摘要：

  Twenty-four acridine derivatives were screened for trypanocidal activity in Trypanosoma brucei in order to determine which structural features of the acridine molecule confer maximal antiparasitic activity. The synthesis of several new azidoacridine derivatives are also reported as well as an assessment of their value as possible photoaffinity probes for the study of acridine trypanocidal action. The most effective and selective acridine trypanocides, with and without irradiation, were the 3-amino-10-methylacridinium salt derivatives. With brief irradiation, one azidoacridine, 3-amino-6-azido-10-methylacridinium chloride, showed considerable trypanocidal activity at very limiting drug concentrations (10(-7)M) and warrants consideration as a possible photoaffinity probe.

  DOI：

  10.1021/jm00373a010
• 作为产物：
  描述：

  2-nitro-9-chloroacridine 在 水 、 iron(II) sulfate 、 calcium carbonate 作用下， 生成 2,9-吖啶二胺
  参考文献：
  名称：

  123.氨基ac啶中氨基的性质。第二部分化学反应的证据

  摘要：

  DOI：

  10.1039/jr9430000458

文献信息

• [EN] AMINOACRIDINE AND AMINOPYRENE DYES AND THEIR USE AS FLUORESCENT TAGS, IN PARTICULAR FOR CARBOHYDRATE ANALYSIS<br/>[FR] COLORANTS AMINOACRIDINE ET AMINOPYRÈNE ET LEUR UTILISATION COMME MARQUEURS FLUORESCENTS, EN PARTICULIER POUR L'ANALYSE DES HYDRATES DE CARBONE
  申请人：MAX PLANCK GESELLSCHAFT

  公开号：WO2021110280A1

  公开（公告）日：2021-06-10

  The invention relates to novel fluorescent dyes with multiple negatively charged groups in their ionized form which are 9-aminoacridines or 1-aminopyreneshaving of one of the following general formulae A-E: or salts or protonated forms thereof, wherein the ionizable groups are typically selected from the following: OH, SH, COOH, SO3H, OSO3H,SO2NHCN, P(O)(OH)2, P(O)(OH)2. The invention further relates to the use of these dyes as fluorescent tags, in particular for reducing sugars and glycans, and to carbohydrate-dye conjugates comprising these dyes as well as to methods for preparing the same.

  该发明涉及具有多个带负电荷基团的新型荧光染料，其在离子化形式下为9-氨基蒽啶或1-氨基吡啶，具有以下通用式A-E之一：或其盐或质子化形式，其中可离子化的基团通常选择自以下基团：OH、SH、COOH、SO3H、OSO3H、SO2NHCN、P(O)(OH)2、P(O)(OH)2。该发明还涉及将这些染料用作荧光标记物，特别是用于还原糖和糖类，以及包括这些染料的碳水化合物-染料共轭物，以及制备它们的方法。
• Chemical derivatives and their application as antitelomerase agent
  申请人：Aventis Pharma S.A.

  公开号：US06645964B1

  公开（公告）日：2003-11-11

  The present invention relates to cancer therapy and to novel anticancer agent having a mechanism of action which is quite specific. It also relates to novel chemical compounds as well as their therapeutic application in humans.

  本发明涉及癌症治疗以及具有相当特异作用机制的新型抗癌剂。它还涉及新型化学化合物以及它们在人类治疗上的治疗应用。
• [EN] ARYLAMINE DERIVATIVES AND THEIR USE AS ANTI-TELOMERASE AGENT<br/>[FR] DERIVES ARYLAMINES ET LEUR APPLICATION COMME AGENT ANTITELOMERASE
  申请人：AVENTIS PHARMA SA

  公开号：WO2001040218A1

  公开（公告）日：2001-06-07

  La présente invention est relative à la thérapie du cancer et concerne de nouveaux agents anticancéreux ayant un mécanisme d'action bien particulier. Elle concerne aussi de nouveaux composés chimiques ainsi que leur application thérapeutique chez l'homme.

  本发明涉及癌症治疗，并涉及具有特定作用机制的新型抗癌剂。它还涉及新的化合物以及它们在人类治疗中的应用。
• Fluorescent dyes and uses thereof
  申请人：Ramage Robert

  公开号：US09127164B2

  公开（公告）日：2015-09-08

  The present invention relates to fluorescent dyes based on acridine derivatives and use of such dyes, for example, in biochemical and/or cell based assays. A preferred feature of some of the dyes described is their long fluorescence lifetimes and their use to label biological molecules.

  本发明涉及基于吖啶衍生物的荧光染料以及这些染料的应用，例如在生物化学和/或基于细胞的测定中。一些所描述的染料的首选特征是它们的长荧光寿命以及它们用于标记生物分子的应用。
• New α,ω-diamido and α,ω-diamino mono-and bi-bridged acridine dimers
  作者：Martine Moisan、Jean-Pierre Galy、Anne-Marie Galy、Jacques Barbe

  DOI：10.1007/bf00808507

  日期：1993.1

  A novel set of dimers derived from 9-amino acridine was prepared and characterized by H-1 and C-13 NMR. These derivatives are bridged at several different positions of the heterocyclic moieties, by the way of alpha,omega-diamido or alpha,omega-diamino side-chains. Additionally the preparation of some bi-bridged compounds was achieved.