(E,E)-4,6-decadiene | 53721-79-2

• 分子结构分类: 有机化合物 - 碳氢化合物 - 不饱和烃
• 英文名称: (E,E)-4,6-decadiene
• 英文别名: deca-4t,6t-diene；4,6-decadiene；E,E-4,6-Decadien；(4E,6E)-deca-4,6-diene
• CAS: 53721-79-2
• 化学式: C₁₀H₁₈
• 分子量: 138.253
• InChiKey: AYIYRUVVFMYKIA-FIFLTTCUSA-N

物化性质

• 保留指数：
  1145;1145

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  (E,E)-4,6-decadiene 在 sodium hydroxide 、 草酰氯 、 三乙胺 、 N,N-二甲基甲酰胺 作用下， 以 四氢呋喃 、 甲醇 、 乙醇 、 苯 为溶剂， 反应 46.0h， 生成
  参考文献：
  名称：

  ACAT inhibitors derived from hetero-Diels-Alder cycloadducts of thioaldehydes

  摘要：

  Acyl-CoA:cholesterol acyltransferase (ACAT) is the enzyme largely responsible for intracellular cholesterol esterification. A systemic inhibitor of ACAT is believed to be able to slow or even reverse the atherosclerotic process. Towards that goal, a series of cyclic sulfides, derived from the hetero-Diels-Alder reaction of thioaldehydes with 1,3-dienes, and bearing carboxamide substituents, were prepared and evaluated for in vitro (in several tissues and species) and ex vivo ACAT inhibition. Minor changes in subsequent structure were found to have a significant effect in optimization of the biological activity of this series of compounds. Copyright (C) 1996 The DuPont Merck Pharmaceutical Company.

  DOI：

  10.1016/0968-0896(96)00143-5
• 作为产物：
  描述：

  (E)-1-Pentenylquecksilberchlorid 在 lithium chloride 、 palladium dichloride 作用下， 以 六甲基磷酰三胺 为溶剂， 生成 (E,E)-4,6-decadiene
  参考文献：
  名称：

  Mercury in organic chemistry. 7. A convenient synthesis of symmetrical conjugated dienes and polyenes

  摘要：

  DOI：

  10.1021/jo00875a004

文献信息

• A stereocontrolled organopalladium route to 2,5-disubstituted pyrrolidine derivatives. Application to the synthesis of a venom alkaloid of the ant species Monomorium latinode
  作者：Jan E. Baeckvall、Hans E. Schink、Z. Dolor Renko

  DOI：10.1021/jo00290a010

  日期：1990.2
• CROMBIE L.; KERTON N. A.; PATTENDEN G., J. CHEM. SOC. PERKIN TRANS. PART 1, 1979, NO 9, 2136-2137
  作者：CROMBIE L.、 KERTON N. A.、 PATTENDEN G.

  DOI：——

  日期：——
• BACKVALL, JAN-E.;SCHINK, HANS E.;RENKO, Z. DOLOR, J. ORG. CHEM., 55,(1990) N, C. 826-831
  作者：BACKVALL, JAN-E.、SCHINK, HANS E.、RENKO, Z. DOLOR

  DOI：——

  日期：——
• ACAT inhibitors derived from hetero-Diels-Alder cycloadducts of thioaldehydes
  作者：Richard G. Wilde、Jeffrey T. Billheimer、Sandie J. Germain、Elizabeth A. Hausner、Paul C. Meunier、Deborah A. Munzer、Janet K. Stoltenborg、Peter J. Gillies、Deborah L. Burcham、Shiew-Mai Huang、John D. Klaczkiewicz、Soo S. Ko、Ruth R. Wexler

  DOI：10.1016/0968-0896(96)00143-5

  日期：1996.9

  Acyl-CoA:cholesterol acyltransferase (ACAT) is the enzyme largely responsible for intracellular cholesterol esterification. A systemic inhibitor of ACAT is believed to be able to slow or even reverse the atherosclerotic process. Towards that goal, a series of cyclic sulfides, derived from the hetero-Diels-Alder reaction of thioaldehydes with 1,3-dienes, and bearing carboxamide substituents, were prepared and evaluated for in vitro (in several tissues and species) and ex vivo ACAT inhibition. Minor changes in subsequent structure were found to have a significant effect in optimization of the biological activity of this series of compounds. Copyright (C) 1996 The DuPont Merck Pharmaceutical Company.
• Mercury in organic chemistry. 7. A convenient synthesis of symmetrical conjugated dienes and polyenes
  作者：Richard C. Larock

  DOI：10.1021/jo00875a004

  日期：1976.6