ethyl 2-O-(3,3-di-tert-butyloxycarbonylpropyl)-4,6-O-benzylidene-1-thio-β-D-galactopyranoside | 206856-93-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: ethyl 2-O-(3,3-di-tert-butyloxycarbonylpropyl)-4,6-O-benzylidene-1-thio-β-D-galactopyranoside
• CAS: 206856-93-1
• 化学式: C₂₈H₄₂O₉S
• 分子量: 554.702
• InChiKey: PDNZGQRBCRESOM-ZOYCBLEFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.01
• 重原子数：
  38.0
• 可旋转键数：
  9.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  109.75
• 氢给体数：
  1.0
• 氢受体数：
  10.0

反应信息

• 作为反应物：
  描述：

  ethyl 2-O-(3,3-di-tert-butyloxycarbonylpropyl)-4,6-O-benzylidene-1-thio-β-D-galactopyranoside 在 4-二甲氨基吡啶 、 2,6-二叔丁基-4-甲基吡啶 作用下， 以 1,4-二氧六环 、 吡啶 、 二氯甲烷 为溶剂， 生成 methyl 9-[2-O-(3,3-di-tert-butyloxycarbonylpropyl)-3-O-benzoyl-4,6-O-benzylidene-β-D-galactopyranosyloxy]-nonanoate
  参考文献：
  名称：

  Novel mimics of sialyl Lewis X

  摘要：

  A series of potent inhibitors of P-selectin as potential anti-inflammatory agents is reported. These compounds are derivatives of galactocerebrosides bearing a malonate side chain in positions 2 and 3 of the galactose moiety. Based on the binding mode of sialyl Lewis X, the two acidic groups of the malonate are designed to form ionic interactions with two important lysines in the active site of P-selectin, Lys113 and Lys111. On the other hand, the 4- and 6-hydroxy groups on the galactose ring are arranged to chelate the calcium ion in the P-selectin active site. The synthesis and the biological activity of this series of compounds are described. Lead compounds having a greater potency than sialyl Lewis X are identified. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(01)00015-3
• 作为产物：
  描述：

  ethyl 6-O-tert-butyldimethylsilyl-3,4-O-isopropylidene-2-O-tert-butyloxycarbonylmethyl-1-thio-β-D-galactopyranoside 在 盐酸 、 lithium aluminium tetrahydride 、 四丁基氟化铵 、 sodium hydride 、 对甲苯磺酸 、 三乙胺 、 potassium iodide 作用下， 以 四氢呋喃 、 二氯甲烷 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 26.5h， 生成 ethyl 2-O-(3,3-di-tert-butyloxycarbonylpropyl)-4,6-O-benzylidene-1-thio-β-D-galactopyranoside
  参考文献：
  名称：

  Novel mimics of sialyl Lewis X

  摘要：

  A series of potent inhibitors of P-selectin as potential anti-inflammatory agents is reported. These compounds are derivatives of galactocerebrosides bearing a malonate side chain in positions 2 and 3 of the galactose moiety. Based on the binding mode of sialyl Lewis X, the two acidic groups of the malonate are designed to form ionic interactions with two important lysines in the active site of P-selectin, Lys113 and Lys111. On the other hand, the 4- and 6-hydroxy groups on the galactose ring are arranged to chelate the calcium ion in the P-selectin active site. The synthesis and the biological activity of this series of compounds are described. Lead compounds having a greater potency than sialyl Lewis X are identified. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(01)00015-3