4-氯-6-硝基-2(1h)-喹啉酮 | 934687-48-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 4-氯-6-硝基-2(1h)-喹啉酮
• 英文名称: 4-chloro-6-nitroquinolin-2(1H)-one
• 英文别名: 4-Chloro-6-nitroquinolin-2(1h)-one；4-chloro-6-nitro-1H-quinolin-2-one
• CAS: 934687-48-6
• 化学式: C₉H₅ClN₂O₃
• mdl: MFCD12024334
• 分子量: 224.603
• InChiKey: BZWQSAMGSLTVJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  74.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-氯-6-硝基-2(1h)-喹啉酮 在 2,2,2-三氟乙醇 、 tin(ll) chloride 作用下， 以 N-甲基吡咯烷酮 、 乙醇 为溶剂， 反应 1.0h， 生成
  参考文献：
  名称：

  Into Deep Water: Optimizing BCL6 Inhibitors by Growing into a Solvated Pocket

  摘要：

  DOI：

  10.1021/acs.jmedchem.1c00946
• 作为产物：
  描述：

  4-氯-2-羟基喹啉 在 硫酸 、 硝酸 作用下， 反应 1.0h， 以97%的产率得到4-氯-6-硝基-2(1h)-喹啉酮
  参考文献：
  名称：

  [EN] 2-QUINOLONE DERIVED INHIBITORS OF BCL6
  [FR] INHIBITEURS DE BCL6 DÉRIVÉS DE 2-QUINOLONE

  摘要：

  本发明涉及作为BCL6（B细胞淋巴瘤6）活性抑制剂的I式化合物：式中X1、X2、X3、R1、R2、R3、R4和R5分别如本文所定义。本发明还涉及制备这些化合物的方法，包括含有它们的药物组合物，以及它们在治疗增生性疾病（如癌症）以及其他BCL6活性所涉及的疾病或病况中的用途。

  公开号：

  WO2018215798A1

文献信息

• [EN] 2-QUINOLONE DERIVED INHIBITORS OF BCL6<br/>[FR] INHIBITEURS DE BCL6 DÉRIVÉS DE 2-QUINOLONE
  申请人：CANCER RESEARCH TECH LTD

  公开号：WO2018215798A1

  公开（公告）日：2018-11-29

  The present invention relates to compounds of formula I that function as inhibitors of BCL6(B- cell lymphoma 6) activity: Formula I wherein X1, X2, X3, R1, R2, R3, R4 and R5 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer,as well as other diseases or conditions in which BCL6 activity is implicated.

  本发明涉及作为BCL6（B细胞淋巴瘤6）活性抑制剂的I式化合物：式中X1、X2、X3、R1、R2、R3、R4和R5分别如本文所定义。本发明还涉及制备这些化合物的方法，包括含有它们的药物组合物，以及它们在治疗增生性疾病（如癌症）以及其他BCL6活性所涉及的疾病或病况中的用途。
• [EN] BCL6 INHIBITORS<br/>[FR] INHIBITEURS DE BCL6
  申请人：CANCER RESEARCH TECH LTD

  公开号：WO2019197842A1

  公开（公告）日：2019-10-17

  The present invention relates to compounds of formula I that function as inhibitors of BCL6 (B-cell lymphoma 6) activity Formula (I) wherein X1, X2, R1, R2, R30, R31 and Ring A are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which BCL6 activity is implicated.

  本发明涉及具有以下公式I的化合物，这些化合物作为BCL6（B细胞淋巴瘤6）活性的抑制剂发挥作用。其中X1, X2, R1, R2, R30, R31和环A均按本发明定义。本发明还涉及制备这些化合物的方法，包含它们的药物组合物，以及它们在治疗增殖性疾病，如癌症，以及BCL6活性涉及的其他疾病或状况中的应用。
• [EN] COMPOUNDS ACTIVE TOWARDS BROMODOMAINS<br/>[FR] COMPOSÉS ACTIFS ENVERS DES BROMODOMAINES
  申请人：NUEVOLUTION AS

  公开号：WO2016016316A1

  公开（公告）日：2016-02-04

  Disclosed are compounds towards bromodomains, pharmaceutical compositions containing the compounds and use of the compounds in therapy.

  揭示了针对溴结构域的化合物，含有这些化合物的药物组合物以及这些化合物在治疗中的用途。
• ANTITUMOR AGENT AND BROMODOMAIN INHIBITOR
  申请人：FUJIFILM Corporation

  公开号：US20190314360A1

  公开（公告）日：2019-10-17

  It is an object of the present invention to provide an antitumor agent, which is further excellent as a treatment agent used in the prevention and/or therapy of tumor associated with a bromodomain, and also to provide a bromodomain inhibitor, which is useful as a treatment agent for diseases or states associated with a bromodomain. An antitumor agent and a bromodomain inhibitor, comprising a compound represented by the following formula, have an excellent bromodomain inhibitory activity and are useful as treatment agents in the prevention and/or therapy of tumor associated with a bromodomain, and the like: wherein R 1 represents a C 1-6 alkyl group, etc.; R 2 represents a hydrogen atom, etc.; R 3 represents a halogen atom, etc.; Z 1 , Z 2 and Z 3 each represent CH, etc.; X 1 represents CONH, etc.; Ring A represents a phenyl group, etc.; R 4 represents a halogen atom, etc.; and m represents an integer from 0 to 5.

  本发明的目的是提供一种抗肿瘤剂，作为与溴结构域相关的肿瘤的预防和/或治疗中使用的治疗剂，该抗肿瘤剂进一步优秀，并提供一种溴结构域抑制剂，用作与溴结构域相关的疾病或状态的治疗剂。包含以下式表示的化合物的抗肿瘤剂和溴结构域抑制剂具有出色的溴结构域抑制活性，并可用作与溴结构域相关的肿瘤的预防和/或治疗等治疗剂： 其中R1代表C1-6烷基基团等；R2代表氢原子等；R3代表卤素原子等；Z1、Z2和Z3各代表CH等；X1代表CONH等；环A代表苯基等；R4代表卤素原子等；m代表0到5的整数。
• Nitrogen-containing heterocyclic compound
  申请人：FUJIFILM Corporation

  公开号：US10696637B2

  公开（公告）日：2020-06-30

  A compound represented by the general formula, or a salt thereof, has exceptional CXCL10 inhibitory activity and is useful as a treatment agent for the prevention and/or treatment, etc., of diseases involving overproduction of CXCL10. In the formula: R1 is a C1-6 alkyl group, etc.; R2 is a hydrogen atom, etc.; R3 is a halogen atom, etc.; Z1, Z2, and Z3 are CH, etc.; X1 is CONH, etc.; ring A is a phenyl group, etc.; R4 is a halogen atom, etc.; and m is an integer of 0-5.

  通式所代表的化合物或其盐具有优异的 CXCL10 抑制活性，可用作预防和/或治疗涉及 CXCL10 过度分泌的疾病等的治疗剂。式中R1是C1-6烷基等；R2是氢原子等；R3是卤素原子等；Z1、Z2和Z3是CH等；X1是CONH等；环A是苯基等；R4是卤素原子等；m是0-5的整数。