3,5-二氨基苯乙酮 | 33786-92-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 3,5-二氨基苯乙酮
• 英文名称: 3,5-diaminoacetophenone
• 英文别名: 1-(3,5-diamino-phenyl)-ethanone；1-(3,5-Diamino-phenyl)-aethanon；3.5-Diamino-acetophenon；3',5'-Diaminoacetophenone；1-(3,5-diaminophenyl)ethanone
• CAS: 33786-92-4
• 化学式: C₈H₁₀N₂O
• mdl: MFCD07787506
• 分子量: 150.18
• InChiKey: FBVMBHXYXPZOFZ-UHFFFAOYSA-N

物化性质

• 沸点：
  392.8±22.0 °C(Predicted)
• 密度：
  1.196±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.125
• 拓扑面积：
  69.1
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2922399090

反应信息

• 作为反应物：
  描述：

  3,5-二氨基苯乙酮 在 氢氧化钾 、 一水合肼 、 三乙二醇 作用下， 反应 2.0h， 生成 3-ethyl-5-amino-phenol
  参考文献：
  名称：

  Über alkylierte p-Aminosalizylsäuren

  摘要：

  DOI：

  10.1007/bf00897796
• 作为产物：
  描述：

  3′,5′-二硝基乙酰苯 在 盐酸 、 tin 作用下， 生成 3,5-二氨基苯乙酮
  参考文献：
  名称：

  Berend; Heymann, Journal fur praktische Chemie (Leipzig 1954), 1902, vol. <2> 65, p. 292

  摘要：

  DOI：

文献信息

• Patentiflorin A Analogs as Antiviral Agents
  申请人：Hong Kong Baptist University

  公开号：US20210060042A1

  公开（公告）日：2021-03-04

  The present disclosure relates to patentiflorin A analogs that are useful as antivirals, such as anti-HIV, anti-coronaviral, anti-Ebola viral, and anti-influenza viral agents and methods of use thereof.

  本公开涉及用作抗病毒药物的帕特尼氟林A类似物，例如抗HIV、抗冠状病毒、抗埃博拉病毒和抗流感病毒药物，以及它们的使用方法。
• METAL CHELATES HAVING A PERFLUORINATED PEG RADICAL, PROCESSES FOR THEIR PREPARATION, AND THEIR USE
  申请人：Platzek Johannes

  公开号：US20080159954A1

  公开（公告）日：2008-07-03

  The invention relates to the subjects characterized in the patent claims, namely metal chelates having a perfluorinated PEG radical, processes for their preparation, and their use, processes for their preparation and their use in NMR and X-ray diagnosis, radiodiagnosis and radiotherapy, and in MRT lymphography.

  本发明涉及专利要求中所描述的主题，即具有全氟聚乙二醇基团的金属螯合物，其制备方法以及它们在核磁共振和X射线诊断、放射诊断和放射治疗以及磁共振淋巴造影中的用途，其制备方法和用途。
• Composition and molded article
  申请人：AKITA UNIVERSITY

  公开号：US10815369B2

  公开（公告）日：2020-10-27

  The invention provides a composition capable of providing a molded article that has excellent heat resistance and a small weight change against oxygen plasma exposure and fluorine plasma exposure during a semiconductor manufacturing step. The composition contains a fluorine-containing polymer and a hyperbranched polymer of a cage silsesquioxane with a specific structure.

  本发明提供了一种组合物，该组合物能够在半导体制造步骤中提供具有优异耐热性和较小重量变化的模制品，使其免受氧等离子体暴露和氟等离子体暴露的影响。该组合物含有一种含氟聚合物和一种具有特定结构的笼状硅倍半氧烷超支化聚合物。
• Design, Synthesis, and Biological Evaluation of Novel Hybrid Dicaffeoyltartaric/Diketo Acid and Tetrazole-Substituted <scp>l</scp>-Chicoric Acid Analogue Inhibitors of Human Immunodeficiency Virus Type 1 Integrase
  作者：David C. Crosby、Xiangyang Lei、Charles G. Gibbs、Brenda R. McDougall、W. Edward Robinson、Manfred G. Reinecke

  DOI：10.1021/jm1010594

  日期：2010.11.25

  Fourteen analogues of the anti-HIV-1 integrase (IN) inhibitor L-chicoric acid (L-CA) were prepared. Their IC50 values for 3'-end processing and strand transfer against recombinant HIV-1 IN were determined in vitro, and their cell toxicities and EC50 against HIV-1 were measured in cells (ex vivo). Compounds 1-6 are catechol/beta-diketoacid hybrids, the majority of which exhibit submicromolar potency against 3'-end processing and strand transfer, though only with modest antiviral activities. Compounds 7-10 are L-CA/p-fluorobenzylpyrroloyl hybrids, several of which were more potent against strand transfer than 3'-end processing, a phenomenon previously attributed to the beta-diketo acid pharmacophore. Compounds 11-14 are tetrazole bioisosteres of L-CA and its analogues, whose in vitro potencies were comparable to L-CA but with enhanced antiviral potency. The trihydroxyphenyl analogue 14 was 30-fold more potent than L-CA at relatively nontoxic concentrations. These data indicate that L-CA analogues are attractive candidates for development into clinically relevant inhibitors of HIV-1 IN.
• Berend; Heymann, Journal fur praktische Chemie (Leipzig 1954), 1904, vol. <2> 69, p. 466
  作者：Berend、Heymann

  DOI：——

  日期：——