5-ethylbenzene-1,3-diamine | 408309-32-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-ethylbenzene-1,3-diamine
• 英文别名: 5-ethyl-m-phenylenediamine；5-Aethyl-m-phenylendiamin
• CAS: 408309-32-0
• 化学式: C₈H₁₂N₂
• mdl: MFCD19210480
• 分子量: 136.197
• InChiKey: YTGJCSNIOLFARW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-ethylbenzene-1,3-diamine 生成 3-ethyl-5-amino-phenol
  参考文献：
  名称：

  Über alkylierte p-Aminosalizylsäuren

  摘要：

  DOI：

  10.1007/bf00897796
• 作为产物：
  描述：

  1,3-二硝基-5-乙烯基-苯 在 palladium 10% on activated carbon 、 氢气 作用下， 以 甲醇 为溶剂， 以83%的产率得到5-ethylbenzene-1,3-diamine
  参考文献：
  名称：

  A structure-guided optimization of pyrido[2,3-d]pyrimidin-7-ones as selective inhibitors of EGFRL858R/T790M mutant with improved pharmacokinetic properties

  摘要：

  Structural optimization of pyrido[2,3-d]pyrimidin-7-ones was conducted to yield a series of new selective EGFR(T790M) inhibitors with improved pharmacokinetic properties. One of the most promising compound 9s potently suppressed EGFR(L858R/T790M) kinase and inhibited the proliferation of H1975 cells with IC50 values of 2.0 nM and 40 nM, respectively. The compound dose-dependently induced reduction of the phosphorylation of EGFR and downstream activation of ERIC in NCI-H1975 cells. It also exhibited moderate plasma exposure after oral administration and an oral bioavailability value of 16%. Compound 9s may serve as a promising lead compound for further drug discovery overcoming the acquired resistance of non-small cell lung cancer (NSCLC) patients. (C) 2016 Published by Elsevier Masson SAS.

  DOI：

  10.1016/j.ejmech.2016.12.006

文献信息

• COMPOSITION FOR FORMING LIQUID CRYSTAL ALIGNMENT FILM AND LIQUID CRYSTAL DISPLAY ELEMENT
  申请人：SOKI CORPORATION

  公开号：US20150056367A1

  公开（公告）日：2015-02-26

  The present invention, which enables to align a liquid crystal molecule, when no voltage is applied thereto, and also to control pretilt angle of the liquid crystal molecule, relates to a composition for a liquid crystal alignment film comprising components represented by the following (A) to (D): (A) a meta-phenylene diamine derivative represented by the general formula [1]; (B) a meta-phenylene diamine derivative represented by the general formula [2]; (C) a para-arylene diamine represented by the general formula [3]; (D) a tetracarboxylic acid represented by the general formula [4] or a tetracarboxylic acid anhydride represented by the general formula [4′]; (wherein R 1 represents an alkyl group having 1 to 6 carbon atoms or the like, R 2 represents an alkyl group having 8 to 20 carbon atoms or the like, t moieties of R a represent an alkyl group having 1 to 3 carbon atoms or the like, n represents an integer of 1 to 3, t represents an integer of 0 to 4, T represents an oxygen atom or the like, Y represents an amino group, and Z represents a tetravalent hydrocarbon group.).

  本发明涉及一种液晶取向膜组合物，包括以下（A）至（D）的组分，能够在不施加电压的情况下使液晶分子对齐，并控制液晶分子的预倾角：（A）由通式[1]表示的间苯二胺衍生物；（B）由通式[2]表示的间苯二胺衍生物；（C）由通式[3]表示的对芳二胺；（D）由通式[4]表示的四羧酸或由通式[4']表示的四羧酸酐；（其中，R1表示具有1至6个碳原子的烷基或类似物，R2表示具有8至20个碳原子的烷基或类似物，R的t个官能团表示具有1至3个碳原子的烷基或类似物，n表示1至3的整数，t表示0至4的整数，T表示氧原子或类似物，Y表示氨基，Z表示四价碳氢基团）。
• Liquid crystal-aligning agent
  申请人：JAPAN SYNTHETIC RUBBER CO., LTD.

  公开号：EP0718666A1

  公开（公告）日：1996-06-26

  A liquid crystal-aligning agent comprising at least one of a polyamic acid obtained by reacting (A) a tetracarboxylic acid dianhydride consisting of 70 to 98 mole % of a dianhydride of a tetracarboxylic acid such as or the like, and 2 to 30 mole % of a dianhydride of a cyclobutanetetracarboxylic acid, and (B) a diamine compound, and a polymer obtained by imidizing the polyamic acid.

  一种液晶对准剂，包含至少一种聚酰胺酸，该聚酰胺酸通过以下反应获得 (A) 由 70 至 98 摩尔%的四羧酸二酐组成的四羧酸二酐，如： (B) 由 70 至 98 摩尔%的四羧酸二酐组成的四羧酸二酐，如： (C) 由 70 至 98 摩尔%的四羧酸二酐组成的四羧酸二酐。 或类似物质、 和 2 至 30 摩尔%的环丁烷四羧酸二酐，以及 (B) 二胺化合物和通过对聚酰胺酸进行酰亚胺化而得到的聚合物。
• Liquid crystal display device
  申请人：SHARP KABUSHIKI KAISHA

  公开号：US11053354B2

  公开（公告）日：2021-07-06

  The present invention provides a liquid crystal display device with a high degree of freedom in molecular structure design of an alignment film and with reduced image sticking. The liquid crystal display device includes a pair of substrates; a liquid crystal layer held between the substrates; an alignment film disposed on a liquid crystal layer side surface of at least one of the substrates; and a polymer layer disposed between the liquid crystal layer and the alignment film, the alignment film containing a first polymer containing at least one structure represented by the following formula (1) in a side chain, wherein R1 represents a C3-C6 branched or cyclic alkylene group, and a hydrogen atom at a para position to a carbonyl group in the phenyl group is optionally replaced.

  本发明提供了一种液晶显示装置，其对准膜的分子结构设计自由度很高，并能减少图像粘连。该液晶显示装置包括一对基板；夹持在基板之间的液晶层；设置在至少其中一个基板的液晶层侧表面上的对准膜；以及设置在液晶层和对准膜之间的聚合物层，对准膜含有第一种聚合物，其侧链中至少含有一种由下式(1)表示的结构、 其中 R1 代表 C3-C6 支链或环状亚烷基，苯基中对位至羰基的氢原子可选择被取代。
• Substituted m-phenylenediamines
  申请人：THE DOW CHEMICAL COMPANY

  公开号：EP0082258B1

  公开（公告）日：1986-02-19
• Transparent, highly heat-resistant polyimide precursor and photosensitive polyimide composition thereof
  申请人：Kim Dong-seok

  公开号：US20070093640A1

  公开（公告）日：2007-04-26

  The present invention relates to an aqueous alkali-developable photosensitive polyimide precursor resin composition that is appropriate for highly heat-resistant transparent protection layers and insulation layers for liquid crystal display devices. In more detail, the present invention relates to a negative-type photosensitive transparent polyimide precursor resin composition manufactured in two steps. The first step is the manufacture of a transparent linear polyamic acid (A) from (a-1) one or more kinds of tetracarboxylic acid dianhydrides selected from alicyclic tetracarboxylic acid dianhydrides having 3 to 30 carbon atoms; and (a-2) one or more kinds of diamines selected from aliphatic, alicyclic, or non-conjugated aromatic diamines, having 3 to 30 carbon atoms, having one or more ethylenically unsaturated bonds at side chains as essential components; and the second step is the manufacture of reactive transparent polyimide precursors shown in the following Chemical Formula 1 according to the esterification reaction of the above polyamic acid (A) with ethylenically unsaturated compound (B) containing an epoxy group in the same molecule as the main component. The photosensitive transparent polyimide precursor resin compositions according to the present invention have a superior photosensitivity, and thus, may be used for transparent protection layers and insulation layers of liquid crystal display devices having superior heat resistance, chemical resistance, mechanical strength, and electricity insulation.