3-(1-Methylbenzo[f]quinolin-3-yl)aniline | 609818-93-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-(1-Methylbenzo[f]quinolin-3-yl)aniline
• CAS: 609818-93-1
• 化学式: C₂₀H₁₆N₂
• 分子量: 284.36
• InChiKey: BAOXNVIGIKOHJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  38.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-(1-Methylbenzo[f]quinolin-3-yl)aniline 、 苯磺酰氯 在 吡啶 作用下， 反应 2.0h， 以49%的产率得到N-[3-(1-methylbenzo[f]quinolin-3-yl)phenyl]benzenesulfonamide
  参考文献：
  名称：

  摘要：

  Three-component condensation of 2-aminonaphthalene, acetone, and substituted benzaldehydes in alcoholic solution in the presence of concentrated hydrochloric acid gave 3-aryl-1-methylbenzo[f]quinolines. 1-Methyl-3-(nitrophenyl)benzo[f]quinolines were reduced to the corresponding amines which were converted into amides having a sulfonyl or chloroacetyl group in the aryl substituent.

  DOI：

  10.1023/a:1026077716902
• 作为产物：
  描述：

  1-methyl-3-(3-nitrophenyl)benzo[f]quinoline 在 盐酸 、 tin(ll) chloride 作用下， 以 异丙醇 为溶剂， 反应 1.0h， 以52%的产率得到3-(1-Methylbenzo[f]quinolin-3-yl)aniline
  参考文献：
  名称：

  摘要：

  Three-component condensation of 2-aminonaphthalene, acetone, and substituted benzaldehydes in alcoholic solution in the presence of concentrated hydrochloric acid gave 3-aryl-1-methylbenzo[f]quinolines. 1-Methyl-3-(nitrophenyl)benzo[f]quinolines were reduced to the corresponding amines which were converted into amides having a sulfonyl or chloroacetyl group in the aryl substituent.

  DOI：

  10.1023/a:1026077716902

文献信息

• ——
  作者：N. G. Kozlov、L. I. Basalaeva

  DOI：10.1023/a:1026077716902

  日期：——

  Three-component condensation of 2-aminonaphthalene, acetone, and substituted benzaldehydes in alcoholic solution in the presence of concentrated hydrochloric acid gave 3-aryl-1-methylbenzo[f]quinolines. 1-Methyl-3-(nitrophenyl)benzo[f]quinolines were reduced to the corresponding amines which were converted into amides having a sulfonyl or chloroacetyl group in the aryl substituent.