1-(9-菲基)甲胺 | 15398-91-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 中文名称: 1-(9-菲基)甲胺
• 英文名称: 9-phenanthrylmethylamine
• 英文别名: C-[9]phenanthryl-methylamine；9-Aminomethyl-phenanthren；9-Phenanthrenemethanamine；phenanthren-9-ylmethanamine
• CAS: 15398-91-1
• 化学式: C₁₅H₁₃N
• 分子量: 207.275
• InChiKey: BINPPAGEURCXIV-UHFFFAOYSA-N

物化性质

• 熔点：
  107 °C
• 沸点：
  160-165 °C
• 密度：
  1.166±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2921499090

反应信息

• 作为反应物：
  描述：

  1-(9-菲基)甲胺 在 sodium acetate 、 乙酸酐 作用下， 以 乙醚 为溶剂， 生成 1-Phenanthren-9-ylmethyl-pyrrole-2,5-dione
  参考文献：
  名称：

  Fluorescent PET(Photoinduced Electron Transfer) reagents for thiols

  摘要：

  DOI：

  10.1016/s0040-4039(98)00909-5
• 作为产物：
  描述：

  9-bromomethylphenantrene 在 sodium azide 、 三苯基膦 作用下， 生成 1-(9-菲基)甲胺
  参考文献：
  名称：

  Macroscopic Self-Assembly Based on Molecular Recognition: Effect of Linkage between Aromatics and the Polyacrylamide Gel Scaffold, Amide versus Ester

  摘要：

  The interactions of polyacrylamide- (pAAm-) based gels possessing cyclodextrin (CD) residues (CD-gels) with pAAm-based gels modified with aromatic residues through amide and ester linkages (ArA-gels and ME-gels, respectively) were investigated to examine the effect of linkage (i.e., amide and ester) between aromatic residues and the pAAm gel scaffold. In the present study, benzyl (Bz), 2-naphthylmethyl (Np), 9-phenanthrylmethyl (Ph), and 1-pyrenylmethyl (Py) residues were chosen as a series of aromatic residues. alpha CD-gel did not interact notably with the MA-gels and ME-gels in water. beta CD-gel interacted with the MA-gels and ME-gels possessing smaller aromatic residues (i.e., Bz and Np residues) in water to form gel assemblies. gamma CD-gel showed different tendencies of its interactions with the MA-gels and with the ME-gels; gamma CD-gel interacted with the MA-gels carrying larger aromatic residues (i.e., Ph and Py residues), while gamma CD-gel formed stable gel assemblies only with NpE-gel among the ME-gels examined. This is because gamma CD residues in gamma CD-gel included favorably dimeric aromatic residues in the MA-gels and ME-gels. Reflection fluorescence spectra for the MA-gels and ME-gels possessing fluorescent aromatic residues (i.e., Np, Ph, and Py residues) in the presence of 10 mM gamma CD were indicative of weak selectivities of gamma CD toward NpE, PhA, and PyA residues. Such weak selectivities may be largely enhanced in the macroscopic observation of interaction of CD-gels with the ArA-gels and ME-gels presumably because of multivalency.

  DOI：

  10.1021/ma302344x

文献信息

• FLUORESCENT ISOINDOLINE DYES
  申请人：THOMPSON Mark E.

  公开号：US20120153266A1

  公开（公告）日：2012-06-21

  The present invention provides a new class of excited state intramolecular charge transfer (ESIPT) dye compounds based on mono or dihydroxy substituted 1,3-bisiminoisoindole motif and metal complexes containing such compounds as ligands. The present invention also provides OLEDs containing the compound and/or metal complex as the emissive material.

  本发明提供了一类新的基于单或双羟基取代的1,3-双亚氨基异吲哚基团和含有这种化合物作为配体的金属配合物的激发态分子内电荷转移（ESIPT）染料化合物。本发明还提供了包含该化合物和/或金属配合物作为发光材料的OLED。
• Fluorescent Isoindoline Dyes
  申请人：The University of Southern California

  公开号：US20150318494A1

  公开（公告）日：2015-11-05

  The present invention provides a new class of excited state intramolecular charge transfer (ESIPT) dye compounds based on mono or dihydroxy substituted 1,3-bisiminoisoindole motif and metal complexes containing such compounds as ligands. The present invention also provides OLEDs containing the compound and/or metal complex as the emissive material.

  本发明提供了一种基于单或双羟基取代的1,3-双亚砜异吲哚基团的激发态分子内电荷转移（ESIPT）染料化合物以及包含此类化合物作为配体的金属配合物。本发明还提供了包含该化合物和/或金属配合物作为发光材料的OLED。
• Design, Synthesis, and in Vitro Activity of Catamphiphilic Reverters of Multidrug Resistance:  Discovery of a Selective, Highly Efficacious Chemosensitizer with Potency in the Nanomolar Range
  作者：Elisabetta Teodori、Silvia Dei、Patricia Quidu、Roberta Budriesi、Alberto Chiarini、Arlette Garnier-Suillerot、Fulvio Gualtieri、Dina Manetti、Maria Novella Romanelli、Serena Scapecchi

  DOI：10.1021/jm980440p

  日期：1999.5.1

  On the basis of the results obtained in previous research, three series of compounds (A-C), derived from verapamil, were designed and synthesized to obtain drugs able to revert multidrug resistance (MDR), an acquired resistance that frequently impairs cancer chemotherapy. The ability of the obtained compounds to revert MDR was evaluated on anthracycline-resistant erythroleukemia K 562 cells, measuring the uptake of THP-adriamycin (pirarubicin) by continuous spectrofluorometric monitoring of the decrease of the fluorescence signal of the anthracycline at 590 nm (lambda(ex) = 480 nm), after incubation with cells. Cardiovascular activity, which is responsible for unwanted side effects, was also evaluated. The results obtained show that many of the compounds studied are potent reverters of MDR and are endowed with reduced cardiovascular activity. One of the compounds (7, MM36) presents a pharmacological profile (unprecedented nanomolar potency, high reversal of MDR, low cardiovascular activity) that makes it a promising drug candidate to treat MDR and a useful tool for studying P-glycoprotein.
• v.Braun, Chemische Berichte, 1937, vol. 70, p. 983
  作者：v.Braun

  DOI：——

  日期：——
• 13. Symmetrical triad prototropic systems. Part IX. The influence of polynuclear aryl groups upon mobility and equilibrium in the αγ-diarylmethyleneazomethine system
  作者：Charles W. Shoppee

  DOI：10.1039/jr9330000037

  日期：——