8'-hydroxy-2'-methyl[3,5']biquinolinyl-7'-carboxylic acid | 1224947-78-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8'-hydroxy-2'-methyl[3,5']biquinolinyl-7'-carboxylic acid
• CAS: 1224947-78-7
• 化学式: C₂₀H₁₄N₂O₃
• 分子量: 330.343
• InChiKey: JHVQVMQWTSIUPB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  8'-hydroxy-2'-methyl[3,5']biquinolinyl-7'-carboxylic acid 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 0.13h， 生成 1-N-(5-hydroxypentyl)-2',3'-O-(4-hydroxymethylbenzylidene)inosine
  参考文献：
  名称：

  A solid-phase approach to the synthesis of N-1-alkyl analogues of cyclic inosine-diphosphate-ribose (cIDPR)

  摘要：

  We report here an efficient solid-phase synthesis of N-1-alkyl-substituted analogues of cyclic inosine-diphosphate-ribose (cIDPR), a mimic of cyclic ADP-ribose (cADPR). Our synthetic strategy makes use of a polystyrene support to which inosine was bonded through a 2',3'-acetal linkage. Insertion of a ea-hydroxy-polymethylene chain of variable length on N-1, followed by conversion into N-1-alkylinosine-bisphosphate derivatives and cyclization, allowed to obtain analogues of cIDPR of various ring size. The cyclization step was carried out both in solid-phase and in solution by pyrophosphate bond formation. The effect of the N-1-polymethylene chain length on the cyclization yields as well as the reaction conditions, which led to the solid-phase pyrophosphate bond formation, were thoroughly investigated. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.01.013
• 作为产物：
  描述：

  methyl 8'-(benzyloxy)-2'-methyl-3',5'-biquinoline-7'-carboxylate 在 氢溴酸 、 溶剂黄146 作用下， 以 水 为溶剂， 反应 18.0h， 生成 8'-hydroxy-2'-methyl[3,5']biquinolinyl-7'-carboxylic acid
  参考文献：
  名称：

  铃木与有机三氟硼酸钾的交叉偶联反应合成5-芳基和5-杂芳基-7-羧基-8-羟基奎纳丁

  摘要：

  基于Suzuki交叉偶联反应，使用有机三氟硼酸钾，由5-溴-7-甲氧基羰基-8-苄氧基奎纳丁制备了一系列5-芳基-和5-杂芳基-7-羧基-8-羟基醌醛。报道了使用微波辅助的氢转移反应对8-羟基进行脱保护的有效方法。 喹啉-交叉偶联-硼-钯-芳基化

  DOI：

  10.1055/s-0029-1218585