(2S,10S,10aS)-9-(allyloxy)-2-(((2R,3S)-3-(2-(allyloxy)phenyl)-3-benzamido-2-((triisopropylsilyl)oxy)propanoyl)oxy)-1,2,3,5,10,10a-hexahydropyrrolo[1,2-b]isoquinolin-10-yl benzoate | 1352213-10-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2S,10S,10aS)-9-(allyloxy)-2-(((2R,3S)-3-(2-(allyloxy)phenyl)-3-benzamido-2-((triisopropylsilyl)oxy)propanoyl)oxy)-1,2,3,5,10,10a-hexahydropyrrolo[1,2-b]isoquinolin-10-yl benzoate
• CAS: 1352213-10-5
• 化学式: C₅₀H₆₀N₂O₈Si
• 分子量: 845.12
• InChiKey: KDMPYAQGJXCSMX-QZVVWSAMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.95
• 重原子数：
  61.0
• 可旋转键数：
  19.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  112.63
• 氢给体数：
  1.0
• 氢受体数：
  9.0

反应信息

• 作为反应物：
  描述：

  (2S,10S,10aS)-9-(allyloxy)-2-(((2R,3S)-3-(2-(allyloxy)phenyl)-3-benzamido-2-((triisopropylsilyl)oxy)propanoyl)oxy)-1,2,3,5,10,10a-hexahydropyrrolo[1,2-b]isoquinolin-10-yl benzoate 在 吡啶 、 氢氟酸 作用下， 以 四氢呋喃 为溶剂， 以84%的产率得到(2S,10S,10aS)-9-allyloxy-10-benzoyloxy-1,2,3,5,10,10a-hexahydropyrrolo[1,2-b]isoquinolin-2-yl (2'R,3'S)-3'-benzoylamino-2'-hydroxy-3'-(2-(allyloxy)phenyl)-propanoate
  参考文献：
  名称：

  Design and synthesis of simplified taxol analogs based on the T-Taxol bioactive conformation

  摘要：

  A series of compounds designed to adopt a conformation similar to the tubulin-binding T-Taxol conformation of the anticancer drug paclitaxel has been synthesized. Both the internally bridged analogs 37-39, 41 and the open- chain analogs 27-29 and 43 were prepared. The bridged analogs 37-39 and 41 were synthesized by Grubbs' metatheses of compounds 30-32 and 33, which, in turn, were prepared by coupling beta-lactams 24-26 with alcohols 22 and 23. Both the bridged and the open- chain analogs showed moderate to good cytotoxicity. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.10.010
• 作为产物：
  描述：

  2-iodo-3-methoxybenzaldehyde 在 吡啶 、 sodium tetrahydroborate 、 正丁基锂 、 氢氟酸 、 三溴化硼 、 三乙酰氧基硼氢化钠 、 sodium hydride 、 potassium carbonate 、 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 、 甲醇 、 正己烷 、 二氯甲烷 、 1,2-二氯乙烷 、 N,N-二甲基甲酰胺 、 mineral oil 为溶剂， 反应 14.51h， 生成 (2S,10S,10aS)-9-(allyloxy)-2-(((2R,3S)-3-(2-(allyloxy)phenyl)-3-benzamido-2-((triisopropylsilyl)oxy)propanoyl)oxy)-1,2,3,5,10,10a-hexahydropyrrolo[1,2-b]isoquinolin-10-yl benzoate
  参考文献：
  名称：

  Design and synthesis of simplified taxol analogs based on the T-Taxol bioactive conformation

  摘要：

  A series of compounds designed to adopt a conformation similar to the tubulin-binding T-Taxol conformation of the anticancer drug paclitaxel has been synthesized. Both the internally bridged analogs 37-39, 41 and the open- chain analogs 27-29 and 43 were prepared. The bridged analogs 37-39 and 41 were synthesized by Grubbs' metatheses of compounds 30-32 and 33, which, in turn, were prepared by coupling beta-lactams 24-26 with alcohols 22 and 23. Both the bridged and the open- chain analogs showed moderate to good cytotoxicity. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.10.010