(2S,10S,10aS)-9-allyloxy-10-hydroxy-2-(tert-butyldimethylsilyloxy)-1,2,3,5,10,10a-hexahydropyrrolo[1,2-b]isoquinoline | 1352212-88-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: (2S,10S,10aS)-9-allyloxy-10-hydroxy-2-(tert-butyldimethylsilyloxy)-1,2,3,5,10,10a-hexahydropyrrolo[1,2-b]isoquinoline
• CAS: 1352212-88-4
• 化学式: C₂₁H₃₃NO₃Si
• 分子量: 375.583
• InChiKey: NUAKNEUKHICFCO-ABSDTBQOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.26
• 重原子数：
  26.0
• 可旋转键数：
  5.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  41.93
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  (2S,10S,10aS)-9-allyloxy-10-hydroxy-2-(tert-butyldimethylsilyloxy)-1,2,3,5,10,10a-hexahydropyrrolo[1,2-b]isoquinoline 在 吡啶 、 氢氟酸 、 sodium hydride 、 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 、 mineral oil 为溶剂， 反应 4.34h， 生成 (2S,10S,10aS)-9-(allyloxy)-2-(((2R,3S)-3-(2-allylphenyl)-3-benzamido-2-((triisopropylsilyl)oxy)propanoyl)oxy)-1,2,3,5,10,10a-hexahydropyrrolo[1,2-b]isoquinolin-10-yl benzoate
  参考文献：
  名称：

  Design and synthesis of simplified taxol analogs based on the T-Taxol bioactive conformation

  摘要：

  A series of compounds designed to adopt a conformation similar to the tubulin-binding T-Taxol conformation of the anticancer drug paclitaxel has been synthesized. Both the internally bridged analogs 37-39, 41 and the open- chain analogs 27-29 and 43 were prepared. The bridged analogs 37-39 and 41 were synthesized by Grubbs' metatheses of compounds 30-32 and 33, which, in turn, were prepared by coupling beta-lactams 24-26 with alcohols 22 and 23. Both the bridged and the open- chain analogs showed moderate to good cytotoxicity. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.10.010
• 作为产物：
  描述：

  2-iodo-3-methoxybenzaldehyde 在 sodium tetrahydroborate 、 正丁基锂 、 三溴化硼 、 三乙酰氧基硼氢化钠 、 potassium carbonate 作用下， 以 四氢呋喃 、 甲醇 、 正己烷 、 二氯甲烷 、 1,2-二氯乙烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 10.17h， 生成 (2S,10S,10aS)-9-allyloxy-10-hydroxy-2-(tert-butyldimethylsilyloxy)-1,2,3,5,10,10a-hexahydropyrrolo[1,2-b]isoquinoline
  参考文献：
  名称：

  Design and synthesis of simplified taxol analogs based on the T-Taxol bioactive conformation

  摘要：

  A series of compounds designed to adopt a conformation similar to the tubulin-binding T-Taxol conformation of the anticancer drug paclitaxel has been synthesized. Both the internally bridged analogs 37-39, 41 and the open- chain analogs 27-29 and 43 were prepared. The bridged analogs 37-39 and 41 were synthesized by Grubbs' metatheses of compounds 30-32 and 33, which, in turn, were prepared by coupling beta-lactams 24-26 with alcohols 22 and 23. Both the bridged and the open- chain analogs showed moderate to good cytotoxicity. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.10.010