3β-hydroxy-11-oxo-olean-12-en-30-oic acid methyl ester | 7558-31-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 3β-hydroxy-11-oxo-olean-12-en-30-oic acid methyl ester
• 英文别名: 3-hydroxy-11-oxo-olean-12-en-30-oic acid methyl ester；3-Hydroxy-11-oxo-olean-12-en-30-saeure-methylester；Glycyrrhetinsaeure-methylester；Glycirrhetinsaeuremethylester；Glycyrrhetinsaeuremethylester；Methyl glycyrrhetate；methyl 10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylate
• CAS: 7558-31-8
• 化学式: C₃₁H₄₈O₄
• 分子量: 484.72
• InChiKey: RMIVRCBSQPCSCQ-UHFFFAOYSA-N

物化性质

• 沸点：
  559.0±50.0 °C(Predicted)
• 密度：
  1.11±0.1 g/cm3(Predicted)
• 物理描述：
  Solid
• 熔点：
  253-255°C

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  35
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  甘草次酸 生成 3β-hydroxy-11-oxo-olean-12-en-30-oic acid methyl ester
  参考文献：
  名称：

  Self-rated quality of life measures: Effect of change to a low-fat, high-fiber, fruit and vegetable enriched diet

  摘要：

  The Polyp Prevention Trial (PPT) was a multicenter randomized clinical trial to determine the effect of a low-fat (20% of energy from fat), high-fiber (18 g/1000 kcal/day), high-fruit/vegetable (3.5 servings/1000 kcal/day) eating plan on the recurrence of large bowel adenomatous polyps. The PPT provided an opportunity to examine the impact of dietary changes on quality of life. At baseline and annually for 4 years, participants in the Quality of Life Substudy of PPT completed a Quality of Life Factors (QF) Questionnaire, a modified Block-National Cancer Institute Food Frequency Questionnaire, and a Health and Lifestyle Questionnaire. The 51-item QF Questionnaire assessed changes in nine domains: taste, convenience, cost, self-care, social, health assessment, health belief health action, and life satisfaction. The analysis compared annual changes in domain scores for intervention (n = 194) and control (n = 200) participants. At Year 1,363 (92%) completed a questionnaire, and 325 (82%) participants completed a Year 4 questionnaire. There were no statistically significant differences between treatment groups in the change from baseline to Year I for the convenience, cost, taste, health assessment, and life satisfaction domains. At Year 1, intervention participants rated the self-care (p < .001), health belief (p = .021), and health action (p < .001) domains significantly higher and the social domain significantly lower (p < .001) than control participants, These changes were consistent through Years 2, 3, and 4. This study provides evidence that, given appropriate support, five-living individuals can successfully alter their eatingpatterns in multiple ways without a negative impact on quality of life.

  DOI：

  10.1207/s15324796abm2303_7

文献信息

• GLYCYRRHETINIC ACID DERIVATIVES AND METHODS OF USE THEREOF
  申请人：AbbVie Inc.

  公开号：US20140073700A1

  公开（公告）日：2014-03-13

  The present application relates to: (a) compounds of Formula (I): and salts thereof, wherein Y and Z are as defined in the specification; (b) compositions comprising such compounds and salts; and (c) methods of use of such compounds, salts, and compositions, particularly use for the treatment and prevention of diseases such as those associated with oxidative stress and inflammation.

  本申请涉及以下内容：(a) 公式(I)化合物及其盐，其中Y和Z如规范中定义；(b) 包含此类化合物和盐的组合物；以及(c) 使用此类化合物、盐和组合物的方法，尤其用于治疗和预防与氧化应激和炎症相关的疾病。
• The effects of exercise on the quality of life of frail older adults: A preplanned meta-analysis of the FICSIT trials
  作者：Kenneth B. Schechtman、Marcia G. Ory

  DOI：10.1207/s15324796abm2303_6

  日期：2001.8

  The Frailty and Injuries: Cooperative Studies of intervention Techniques (FICSIT) was a linked series of randomized clinical trials focused on the benefits of exercise in the frail elderly. This article uses covariate-adjusted preplanned meta-analyses of FICSIT data to evaluate the effect of exercise on quality of life (QOL) outcomes (N = 1,733; age = 73.4 +/- 6.1 years). Results indicate that (a) exercise produced a small but significant improvement in the emotional health component of QOL, trended toward an improved social component, and did not effect perceptions of general health; (b) exercise-related joint and muscle stresses did not increase bodily pain; and (c) QOL improvements were independent of changes in physical functioning. We conclude that exercise can improve QOL in the frail elderly but that the magnitude of the improvement is modest in size. The benefits of a meta-analytical approach for documenting efficacy outcomes across different types of interventions are discussed.
• Kariyone; Nonaka, Chemisches Zentralblatt, 1937, vol. 108, # II, p. 413
  作者：Kariyone、Nonaka

  DOI：——

  日期：——
• Ruzicka; Furter; Leuenberger, Helvetica Chimica Acta, 1937, vol. 20, p. 321
  作者：Ruzicka、Furter、Leuenberger

  DOI：——

  日期：——
• Appraised control, coping, and stress in a community sample: A test of the goodness-of-fit hypothesis
  作者：Sandra G. Zakowski、Martica H. Hall、Laura Cousino Klein、Andrew Baum

  DOI：10.1207/s15324796abm2303_3

  日期：2001.8

  Lazarus and Folkman proposed one of the most comprehensive theories of stress and coping in the psychology literature, but many of their postulates have received little empirical attention, and some of the existing research has yielded contradictory findings. This longitudinal study sought to clarify the associations among control appraisal, coping, and stress within this theoretical framework. The theory postulates that coping strategies used tend to match the level of appraised controllability of the stressor (matching hypothesis). It further states that the effects of problem-focused versus emotion-focused coping are moderated by the appraised controllability of the stressor (goodness-of-fit hypothesis). An alternative to the latter is the main-effects hypothesis, which states that problem-focused coping is generally more effective in reducing distress regardless of appraisal. These hypotheses were tested on 72 adults who completed questionnaires on coping and control appraisal. Stress was assessed using self-report (Symptom Checklist-90-Revised) and a behavioral measure (proofreading task) at two times approximately 2 months apart. Appraised control significantly predicted type of coping such that greater control was associated with more problem-focused and less emotion-focused coping. Although the main-effects hypothesis was not supported, the goodness-of-fit hypothesis was partly confirmed by a significant control by emotion-focused coping interaction predicting both self-report and behavioral measures of stress.