(4aS)-5t,10c-diacetoxy-2,2,6at,6bc,9,9,12ac-heptamethyl-4ar-hydroxymethyl-(8atH,12btH,14bcH)-Δ¹⁴-eicosahydro-picene | 39701-83-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (4aS)-5t,10c-diacetoxy-2,2,6at,6bc,9,9,12ac-heptamethyl-4ar-hydroxymethyl-(8atH,12btH,14bcH)-Δ¹⁴-eicosahydro-picene
• 英文别名: (4aS)-5t,10c-Diacetoxy-2,2,6at,6bc,9,9,12ac-heptamethyl-4ar-hydroxymethyl-(8atH,12btH,14bcH)-Δ¹⁴-eicosahydro-picen；Primulagenin A 3β,16α-diacetat；3,16-Di-O-acetyl-primulagenin A
• CAS: 39701-83-2
• 化学式: C₃₄H₅₄O₅
• 分子量: 542.8
• InChiKey: UPHICCRLUXGBTL-PFRBTJLLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.25
• 重原子数：
  39.0
• 可旋转键数：
  3.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  72.83
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  (4aS)-5t,10c-diacetoxy-2,2,6at,6bc,9,9,12ac-heptamethyl-4ar-hydroxymethyl-(8atH,12btH,14bcH)-Δ¹⁴-eicosahydro-picene 在 氢氧化钾 作用下， 生成 报春花甙元
  参考文献：
  名称：

  Maintaining Gut Integrity During Parenteral Nutrition of Tumor-Bearing Rats: Effects of Glucagon-Like Peptide 2

  摘要：

  Maintaining tumor-bearing rats on total parenteral nutrition (TPN)for eight days significantly reduced mass, protein, and DNA in small intestine and colon. Coinfusion of glucagon-like peptide 2 (GLP-2) significantly increased each of these variables in the duodenum, jejunum, and ileum, but not in the colon. Histological analysis of tissue revealed normal mucosa thickness and villus height in the small intestine of GLP-2-treated rats, whereas nontreated rats maintained on TPN exhibited villus shortening and thinning of the mucosa. Compared with TPN alone, no significant effects of GLP-2 were noted on tumor growth, liver weight, or heart weight. Coinfusion of GLP-2 with TPN had no significant effect on TPN-associated immunosuppression, as measured by mitogen-induced proliferation of cultured splenocytes. Although translocation of bacteria to the mesenteric lymph nodes appeared to be reduced in GLP-2-treated vats, the difference between groups was not statistically significant. These results suggest that hormonal alterations may be more important than an absence of luminal nutrition in TPN-associated mucosa changes in tumor-bearing rats. Additionally, maintenance of gut integrity during TPN does not appear to be a sufficient condition for the avoidance of the negative sequelae associated with this route of supplemental nutrition.

  DOI：

  10.1207/s15327914nc372_15
• 作为产物：
  描述：

  3β.16α-diacetoxy-oleanene-(12)-thioic acid-(28)-S-methyl ester 在 乙醚 、 乙醇 、 镍 作用下， 生成 (4aS)-5t,10c-diacetoxy-2,2,6at,6bc,9,9,12ac-heptamethyl-4ar-hydroxymethyl-(8atH,12btH,14bcH)-Δ¹⁴-eicosahydro-picene
  参考文献：
  名称：

  Maintaining Gut Integrity During Parenteral Nutrition of Tumor-Bearing Rats: Effects of Glucagon-Like Peptide 2

  摘要：

  Maintaining tumor-bearing rats on total parenteral nutrition (TPN)for eight days significantly reduced mass, protein, and DNA in small intestine and colon. Coinfusion of glucagon-like peptide 2 (GLP-2) significantly increased each of these variables in the duodenum, jejunum, and ileum, but not in the colon. Histological analysis of tissue revealed normal mucosa thickness and villus height in the small intestine of GLP-2-treated rats, whereas nontreated rats maintained on TPN exhibited villus shortening and thinning of the mucosa. Compared with TPN alone, no significant effects of GLP-2 were noted on tumor growth, liver weight, or heart weight. Coinfusion of GLP-2 with TPN had no significant effect on TPN-associated immunosuppression, as measured by mitogen-induced proliferation of cultured splenocytes. Although translocation of bacteria to the mesenteric lymph nodes appeared to be reduced in GLP-2-treated vats, the difference between groups was not statistically significant. These results suggest that hormonal alterations may be more important than an absence of luminal nutrition in TPN-associated mucosa changes in tumor-bearing rats. Additionally, maintenance of gut integrity during TPN does not appear to be a sufficient condition for the avoidance of the negative sequelae associated with this route of supplemental nutrition.

  DOI：

  10.1207/s15327914nc372_15

文献信息

• Chemistry of aegiceras majus gaertn—III
  作者：K.Venkateswara Rao、P.K. Bose

  DOI：10.1016/s0040-4020(01)92693-6

  日期：1962.1

  Aegiceradiol, C30H48O2, a new triterpene diol from Aegicera majus Gaertn, is 3β,28-dihydroxy olean-12,15-diene and its partial synthesis from genin-A is described.

  得自Aegicera majus Gaertn的新的三萜二醇Aegiceradiol，C 30 H 48 O 2是3β，28-二羟基齐聚物-12，15-二烯，并且描述了其从genin-A的部分合成。