[EN] AMINOLIPIDOIDS AND USES THEREOF<br/>[FR] AMINOLIPIDOÏDES ET UTILISATIONS DE CEUX-CI
申请人:PRECERES INC
公开号:WO2017100744A1
公开(公告)日:2017-06-15
The present disclosure is directed to novel aminolipidoids, formulations thereof further comprising at least one active agent, as well as methods of delivering the at least one active agent to a target organism.
Selective carbon-hydrogen bond hydroxylation using an engineered cytochrome P450 peroxygenase
作者:Jinia Akter、Tegan P. Stockdale、Stella A. Child、Joel H.Z. Lee、James J. De Voss、Stephen G. Bell
DOI:10.1016/j.jinorgbio.2023.112209
日期:2023.7
linear fatty acids tested (undecanoic through to hexadecenoic acid) when compared to the wild-type heme domain. The product distributions arising from fatty acid oxidation using this peroxygenase variant were broadly similar to those obtained with the wild-type monooxygenase holoenzyme, with oxidation occurring predominantly at the ω-1 through to ω-3 positions. 10-Undecenoic acid was regioselectively
Efficient biocatalytic C–H bond oxidation: an engineered heme-thiolate peroxygenase from a thermostable cytochrome P450
作者:Alecia R. Gee、Isobella S. J. Stone、Tegan P. Stockdale、Tara L. Pukala、James J. De Voss、Stephen G. Bell
DOI:10.1039/d3cc04626e
日期:——
highly sought after reaction in chemical synthesis is the activation of unactivated carbon–hydrogen bonds. We demonstrate the hydroxylation of fatty acidsusing an engineered thermostable archaeal cytochrome P450 enzyme. By replacing a seven aminoacid section of the I-helix, the nicotinamide cofactor-dependent monooxygenase was converted into a hydrogen peroxide using peroxygenase, enabling the efficient
化学合成中备受追捧的反应是未活化的碳氢键的活化。我们使用工程化的热稳定古菌细胞色素 P450 酶演示了脂肪酸的羟基化。通过替换 I 螺旋的 7 个氨基酸部分,烟酰胺辅因子依赖性单加氧酶使用过加氧酶转化为过氧化氢,从而能够在室温至 90 °C 下对 C-H 键进行有效的生物催化氧化。
Polysaccharide derivative, and preparation process and use thereof
申请人:Kao Corporation
公开号:EP0781780A2
公开(公告)日:1997-07-02
Disclosed herein are a polysaccharide derivative obtainable by substituting a part or the whole of hydrogen atoms of hydroxyl groups in a polysaccharide or a derivative thereof by the following substituents (A) and (B):
(A) a hydrophobic group containing a C10-C40 alkyl, alkenyl or acyl group which may be substituted by an -OH group or into which an oxycarbonyl group (-COO- or -OCO-) may be introduced; and
(B) a C1-C5 sulfoalkyl group which may be substituted by an -OH group, or a salt thereof,
wherein average degrees of substitution by the substituents (A) and (B) per monosaccharide residue are 0.001-1.0 and 0.01-2.0, respectively; a preparation process thereof; and use of the polysaccharide derivative for a thickener for cosmetic compositions.
An object of the present invention is to provide a biodegradable block copolymer having high conformability and excellent degradability. The present invention provides a block copolymer including a polyalkylene glycol block and a polyhydroxyalkanoic acid block, wherein the mass ratio of the polyalkylene glycol block with respect to the total mass is 10 to 60%; the carbonyl carbon has a carbon nuclear relaxation time T1ρ of not more than 20 ms; and the block copolymer satisfies the following Equation 1: χ=χ1×χ2≥20 [χ1: crystallization rate of the polyalkylene glycol block; χ2: crystallization rate of a poly-A block, wherein A represents, among the repeat units contained in the polyhydroxyalkanoic acid block, a repeat unit whose homopolymer composed of the same repeat units has a highest crystallization rate].
本发明的目的是提供一种具有高保形性和优异降解性的可生物降解嵌段共聚物。本发明提供了一种嵌段共聚物,包括聚亚烷基二醇嵌段和聚羟基烷酸嵌段,其中聚亚烷基二醇嵌段占总质量的质量比为 10-60%;羰基碳的碳核弛豫时间 T1ρ 不大于 20ms;嵌段共聚物满足以下公式 1:χ=χ1×χ2≥20[χ1:聚烷基乙二醇嵌段的结晶速率;χ2:聚 A 嵌段的结晶速率,其中 A 代表聚羟基烷酸嵌段所含重复单元中,由相同重复单元组成的均聚物具有最高结晶速率的重复单元]。