5'-O-acetylguanosine | 28220-16-8

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 5'-O-acetylguanosine
• 英文别名: 5'-acetyl guanosine；O^5'-acetyl-guanosine；O^5'-Acetyl-guanosin；[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl acetate
• CAS: 28220-16-8
• 化学式: C₁₂H₁₅N₅O₆
• 分子量: 325.281
• InChiKey: BSPZZSXFWWMDMA-IOSLPCCCSA-N

物化性质

• 熔点：
  192-193 °C
• 密度：
  1.99±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.9
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  161
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  5'-O-acetylguanosine 以 ammonium hydroxide 为溶剂， 生成 guanosine 3'-methylenebis(phosphonate)
  参考文献：
  名称：

  A direct method for the synthesis of nucleoside 5′-methylenebis(phosphonate)s from nucleosides

  摘要：

  An efficient method for the preparation of nucleoside 5'-methylenebis(phosphonate)s has been developed. Unprotected nucleosides are phosphonylated directly with methylenebis(phosphonic dichloride). Reaction conditions were optimized to prevent side product formation. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.02.069
• 作为产物：
  描述：

  2',3',5'-三乙酰鸟苷 以61%的产率得到5'-O-acetylguanosine
  参考文献：
  名称：

  通过使用适当保护的7-甲基鸟苷二磷酸酯衍生物作为三磷酸酯键形成的供体来合成带帽寡核糖核苷酸的新方法

  摘要：

  合成了由酸不稳定的4,4'，4''-三甲氧基三苯甲基和甲氧基亚甲基保护的7-甲基鸟苷5'-二磷酸衍生物（），并用作形成三磷酸键的给体组分，得到了封端的六核糖核苷酸，m 7 ģ 5' pppGUAUUA，以改进的收率。

  DOI：

  10.1016/0040-4039(88)85060-3

文献信息

• Flavour Modulating Derivative of a Carboxylic Acid and a Purine, Pyrimidine, Nucleoside, or Nucleotide
  申请人：De Klerk Adri

  公开号：US20100074850A1

  公开（公告）日：2010-03-25

  The present invention relates to the field of improving the flavour of foodstuffs, beverages, tobacco products, pharmaceutics and oral care products. More particularly, the present invention provides flavour modulating substances selected from the group represented by formula (1): and edible salts thereof and edible esters thereof, which can advantageously be used for modulating the flavour of foodstuffs, beverages, tobacco products, pharmaceutics and oral care products. These flavour modulating substances can be used to impart desirable taste attributes in a wide variety of applications and products. In addition, the present flavour modulating substances are capable of modulating the taste and/or aroma impact of other, flavour imparting, substances contained within these same products, thereby improving the overall flavour quality of these products.

  本发明涉及改善食品、饮料、烟草制品、药品和口腔护理产品口味的领域。更具体地说，本发明提供了从由式（1）表示的组中选取的口味调节物质及其可食用盐和可食用酯，这些物质可以有利地用于调节食品、饮料、烟草制品、药品和口腔护理产品的口味。这些口味调节物质可用于赋予各种应用和产品中的理想口味特性。此外，本发明的口味调节物质能够调节这些产品中所含其他赋味物质的口味和/或香气影响，从而改善这些产品的整体口味质量。
• Clay‐Mediated Selective Hydrolysis of 5′‐<i>O</i>‐Acetyl‐2′,3′‐isopropylidene/Cyclohexylidene Nucleosides
  作者：Mukund K. Gurjar、Dhananjoy Mondal、S. V. Ravindranadh、Mukund S. Chorghade

  DOI：10.1080/00397910600639968

  日期：2006.8

  Abstract A generalized procedure for the selective hydrolysis of 5′‐O‐acetyl‐2′,3′‐isopropylidene/cyclohexylidene nucleosides with a solid catalyst, Montmorillonite K‐10 in refluxing methanol, to furnish 5′‐O‐acetyl‐nucleosides is described.

  摘要 用固体催化剂蒙脱石 K-10 在回流甲醇中选择性水解 5'-O-乙酰基-2',3'-异亚丙基/亚环己基核苷以提供 5'-O-乙酰基核苷的通用程序是描述。
• Oxypurine nucleosides and their congeners, and acyl derivatives thereof, for improvement of hematopoiesis
  申请人：Pro-Neuron, Inc.

  公开号：US20040235782A1

  公开（公告）日：2004-11-25

  The invention relates to certain oxypurine nucleosides, congeners of such oxypurine nucleosides, and acyl derivatives thereof, and compositions which contain at least one of these compounds. The invention also relates to methods of treating or preventing hematopoietic disorders and modifying hematopoiesis, and treating or preventing inflammatory diseases and bacterial infections by administering a compound or composition of the present invention to an animal.

  本发明涉及某些氧杂嘌呤核苷、这些氧杂嘌呤核苷的同系物和酰基衍生物，以及至少含有这些化合物之一的组合物。本发明还涉及通过向动物施用本发明的化合物或组合物来治疗或预防造血障碍和调节造血以及治疗或预防炎症性疾病和细菌感染的方法。
• SUBSTITUTED NUCLEOSIDE AND NUCLEOTIDE ANALOGS
  申请人：Beigelman Leonid

  公开号：US20100249068A1

  公开（公告）日：2010-09-30

  Disclosed herein are nucleotide analogs with protected phosphates, methods of synthesizing nucleotide analogs with protected phosphates and methods of treating diseases and/or conditions such as viral infections, cancer, and/or parasitic diseases with the nucleotide analogs with protected phosphates.

  本文公开了一种具有保护磷酸酯的核苷酸类似物，合成具有保护磷酸酯的核苷酸类似物的方法以及使用具有保护磷酸酯的核苷酸类似物治疗病毒感染、癌症和/或寄生虫病等疾病和/或病况的方法。
• Polynucleotide assay reagent and method
  申请人：ANTIVIRALS INC.

  公开号：EP0639582A2

  公开（公告）日：1995-02-22

  The invention provides a use of a morpholino subunit of the formula (I) where P is a purine or pyrimidine base-pairing moiety, and T is H or an N-protective group, for the production of a polymer capable of hydrogen-bonding to complementary bases in a polynucleotide, where in said polymer (i) the subunits are joined predominantly by substantially uncharged, achiral linkages, and (ii) each linkage joins the morpholino nitrogen of one subunit to the 5' exocyclic carbon of an adjacent subunit.

  本发明提供了式 (I) 吗啉亚基的用途 其中 P 是嘌呤或嘧啶碱基配对分子，T 是 H 或 N 保护基团，用于生产能够与多核苷酸中的互补碱基发生氢键连接的聚合物，在所述聚合物中，(i) 亚基主要通过基本上不带电的非手性连接物连接，(ii) 每个连接物将一个亚基的吗啉基氮连接到相邻亚基的 5'外环碳上。