8,10-octadecanedione | 86325-00-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 8,10-octadecanedione
• 英文别名: Octadecane-8,10-dione
• CAS: 86325-00-0
• 化学式: C₁₈H₃₄O₂
• 分子量: 282.467
• InChiKey: JYSWKHQKHYBRIH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  20
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  镍,[碳酸(2-)-κO]- 、 硫化氢 、 8,10-octadecanedione 在 盐酸 作用下， 以 甲醇 、 乙醇 为溶剂， 以61%的产率得到
  参考文献：
  名称：

  Oligomerization and isomerization of olefins by catalysts derived from nickel complexes of dithio-β-diketonates

  摘要：

  The complexes [Ni{R1C(S)CR2C(S)R3}2] 1 and [Ni(R1C(S)CR2C(S)R3}(PL1L2L3)X] 2 (R, L = alkyl, aryl or CF3; X = Cl, Br or 1) have been prepared. The complexes 2 can be chemically anchored to polystyrene or silica-alumina supports via pendant phosphine ligands to form the derivatives 3. The species 2 and 3 in combination with a suitable co-catalyst form extremely active catalysts for the oligomerization of ethylene, propylene or butenes. The immobilised systems show no significant signs of leaching after 24 h operation. In general the oligomerization is highly selective to dimers, however, selectivity and catalyst activity are markedly affected by changes in L. Changes in R affect catalyst activity only.

  DOI：

  10.1039/dt9930000059
• 作为产物：
  描述：

  2-癸酮 、 辛酸乙酯 在 sodium hydride 作用下， 以 乙二醇二甲醚 为溶剂， 反应 2.5h， 以57%的产率得到8,10-octadecanedione
  参考文献：
  名称：

  Oligomerization and isomerization of olefins by catalysts derived from nickel complexes of dithio-β-diketonates

  摘要：

  The complexes [Ni{R1C(S)CR2C(S)R3}2] 1 and [Ni(R1C(S)CR2C(S)R3}(PL1L2L3)X] 2 (R, L = alkyl, aryl or CF3; X = Cl, Br or 1) have been prepared. The complexes 2 can be chemically anchored to polystyrene or silica-alumina supports via pendant phosphine ligands to form the derivatives 3. The species 2 and 3 in combination with a suitable co-catalyst form extremely active catalysts for the oligomerization of ethylene, propylene or butenes. The immobilised systems show no significant signs of leaching after 24 h operation. In general the oligomerization is highly selective to dimers, however, selectivity and catalyst activity are markedly affected by changes in L. Changes in R affect catalyst activity only.

  DOI：

  10.1039/dt9930000059

文献信息

• Design and synthesis of analogues of ionomycin
  作者：Thomas Q. Hu、Larry Weller

  DOI：10.1139/v94-187

  日期：1994.6.1

  Based on the analysis of the crystal structure of the Ca²⁺ salt of ionomycin and the chemical and physical data on ionomycin, a number of ionomycin analogues have been synthesized to study the structural features affecting the Ca²⁺ binding and transport. Compounds 2, 3, and 4 were synthesized to study the effect of additional intramolecular oxygen coordination sites on Ca²⁺ transport. Compounds 5a–5d were prepared to study the effect of lipid solubility on Ca²⁺ binding and transport. Compounds 6a–6c were prepared to study the effect of the distance between the β-diketone and the carboxyl group on Ca²⁺ transport. A general synthetic route to these compounds has been developed. The key reactions in this route are the consecutive regioselective alkylations of the dianion of 2,4-pentanedione with the appropriate bromides.[Formula: see text]

  根据对离子霉素（ionomycin）的Ca²⁺盐的晶体结构分析以及对离子霉素的化学和物理数据，合成了许多离子霉素类似物以研究影响Ca²⁺结合和传输的结构特征。化合物2、3和4被合成用于研究额外的分子内氧配位位点对Ca²⁺传输的影响。化合物5a–5d被制备用于研究脂溶性对Ca²⁺结合和传输的影响。化合物6a–6c被制备用于研究β-二酮和羧基之间距离对Ca²⁺传输的影响。已经开发了这些化合物的一般合成路线。该路线中的关键反应是对2,4-戊二酮的二阴离子进行连续的区域选择性烷基化反应，使用适当的溴化物。
• US4036605A
  申请人：——

  公开号：US4036605A

  公开（公告）日：1977-07-19
• Oligomerization and isomerization of olefins by catalysts derived from nickel complexes of dithio-β-diketonates
  作者：Ramyani Abeywickrema、Martin A. Bennett、Kingsley J. Cavell、Michael Kony、Anthony F. Masters、Alison G. Webb

  DOI：10.1039/dt9930000059

  日期：——

  The complexes [NiR1C(S)CR2C(S)R3}2] 1 and [Ni(R1C(S)CR2C(S)R3}(PL1L2L3)X] 2 (R, L = alkyl, aryl or CF3; X = Cl, Br or 1) have been prepared. The complexes 2 can be chemically anchored to polystyrene or silica-alumina supports via pendant phosphine ligands to form the derivatives 3. The species 2 and 3 in combination with a suitable co-catalyst form extremely active catalysts for the oligomerization of ethylene, propylene or butenes. The immobilised systems show no significant signs of leaching after 24 h operation. In general the oligomerization is highly selective to dimers, however, selectivity and catalyst activity are markedly affected by changes in L. Changes in R affect catalyst activity only.