4-methoxy-1-nonene | 90246-13-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-methoxy-1-nonene
• 英文别名: 4-Methoxynon-1-ene
• CAS: 90246-13-2
• 化学式: C₁₀H₂₀O
• 分子量: 156.268
• InChiKey: GROBLVPOYREWJO-UHFFFAOYSA-N

物化性质

• 沸点：
  57-59 °C(Press: 2 Torr)
• 密度：
  0.799±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  11
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-methoxy-1-nonene 在 2,6-二甲基吡啶 、 氧气 、 臭氧 、 N,N-二异丙基乙胺 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 反应 6.0h， 生成 (4R,6S,8R)-6-(tert-butyldimethylsilyloxy)-8-methoxytridec-1-en-4-yl acrylate
  参考文献：
  名称：

  Design and synthesis of pironetin analogues with simplified structure and study of their interactions with microtubules

  摘要：

  The preparation preparation of a series of pironetin analogues with simplified structure is described. Their cytotoxic activity and their interactions with tubulin have been investigated. It has been found that, while less active than the parent molecule, the pironetin analogues still share the mechanism of action of the latter and compete for the same binding site to alpha-tubulin. Variations in the configurations of their stereocenters do not translate into relevant differences between biological activities. (C) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.02.011
• 作为产物：
  描述：

  正己醛 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 13.08h， 生成 4-methoxy-1-nonene
  参考文献：
  名称：

  On the role of β-silyloxy- and β-alkoxyaldehyde protecting groups in Mukaiyama aldol 1,3-diastereocontrol

  摘要：

  DOI：

  10.1016/j.tetlet.2022.154203

文献信息

• o-Benzenedisulfonimide as a Reusable Brønsted Acid Catalyst for Hosomi-Sakurai Reactions
  作者：Stefano Dughera、Margherita Barbero、Stefano Bazzi、Silvano Cadamuro、Claudia Piccinini

  DOI：10.1055/s-0029-1217093

  日期：2010.1

  lene in the presence of a catalytic amount of the Brønsted acid o-benzenedisulfonimide under mild conditions to give good yields of the corresponding products. The catalyst can be easily recovered and purified for use in further reactions, which has economic and ecological advantages. homogeneous catalysis - Brønsted acid - Hosomi-Sakurai­ reaction - acetals - alcohols

  在催化量的布朗斯台德酸邻苯二磺酰亚胺的存在下，各种缩醛或醇与烯丙基（三甲基）硅烷或1-苯基-2-（三甲基甲硅烷基）乙炔在温和的条件下反应，可得到相应产物的良好收率。该催化剂可以容易地回收和纯化以用于进一步的反应，这具有经济和生态优势。 均相催化-布朗斯台德酸-Hosomi-Sakurai反应-缩醛-醇
• Chemistry of organosilicon compounds. 191. Acetalization of carbonyl compounds with alkoxysilanes catalyzed by iodotrimethylsilane. One-pot allylation reactions of carbonyl compounds to homoallyl ethers using an allylsilane
  作者：Hideki Sakurai、Koshi Sasaki、Josaburo Hayashi、Akira Hosomi

  DOI：10.1021/jo00189a032

  日期：1984.7
• 1,2-Elimination of alcohol from homoallyl ethers under the influence of mixed metal bases
  作者：Christian Margot、Michèle Rizzolio、Manfred Schlosser

  DOI：10.1016/s0040-4020(01)82022-6

  日期：1990.1
• Rhenium complex-catalyzed allylation of acetals with allyltrimethylsilane
  作者：Yutaka Nishiyama、Keiko Shimoura、Noboru Sonoda

  DOI：10.1016/j.tetlet.2008.09.001

  日期：2008.11

  It was confirmed that the treatment of acetals with allyltrimethylsilane in the presence of a catalytic amount of the rhenium complex, ReBr(CO)(5), gave the corresponding homoallylic ethers in excellent to good yields. (C) 2008 Elsevier Ltd. All rights reserved.
• A novel one-step method for the reductive allylation of esters and the first total synthesis of (±)-erythrococcamide B
  作者：Roman Lagoutte、James A. Wilkinson

  DOI：10.1016/j.tetlet.2010.10.159

  日期：2010.12

  A novel and convenient one-step method for the reductive allylation of aliphatic and alicyclic esters using InBr3 as a catalyst is reported. This methodology has also been applied in the first total synthesis of (+/-)-erythrococcamide B. (C) 2010 Elsevier Ltd. All rights reserved.