2-(p-dimethylaminostyryl)quinoline | 48189-64-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-(p-dimethylaminostyryl)quinoline
• 英文别名: (E)-N,N-dimethyl-4-(2-(quinolin-2-yl)vinyl)benzenamine；N,N-dimethyl-4-[(E)-2-(quinolin-2-yl)ethenyl]-aniline；(E)-N,N-dimethyl-4-(2-(quinolin-2-yl)vinyl)aniline；2-<4-(dimethylamino)styryl>quinoline；(E)-2-(4-(dimethylamino)styryl)quinoline；(E)-2-(4-dimethylamino-styryl)-quinoline；2-(4-Dimethylaminostyryl)quinoline；N,N-dimethyl-4-[(E)-2-quinolin-2-ylethenyl]aniline
• CAS: 48189-64-6
• 化学式: C₁₉H₁₈N₂
• 分子量: 274.365
• InChiKey: YMIKUHVSRFHPOP-YRNVUSSQSA-N

物化性质

• 沸点：
  451.7±24.0 °C(Predicted)
• 密度：
  1.152±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  16.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(p-dimethylaminostyryl)quinoline 、 phenylmagnesium bromide 生成 4-(2-[2]quinolyl-1-phenyl-ethyl)-N,N-dimethyl-aniline
  参考文献：
  名称：

  对-二甲氨基-苯甲醛-chinaldin。Ein Beitrag zur Kenntnis der Wirkung发色团和辅助色团Gruppen

  摘要：

  DOI：

  10.1002/hlca.193501801192
• 作为产物：
  描述：

  2-[2]quinolyl-1-(4-dimethylamino-phenyl)-ethanol 在 甲基磺酰氯 、 三乙胺 作用下， 以80%的产率得到2-(p-dimethylaminostyryl)quinoline
  参考文献：
  名称：

  Biological evaluation of substituted quinolines

  摘要：

  Several quinolines were synthesized and evaluated in vitro against several parasites (Trypanosoma brucei, T. cruzi, Leishmania infantum, L. amazonensis, Plasmodium falciparum). Then, they were evaluated in vitro (at 10 muM), against HTLV-1 transformed cells. A few of them displayed interesting activities, comparable to the reference drugs. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.05.026

文献信息

• Imaging agents for detecting neurological disorders
  申请人：Gangadharmath Umesh B.

  公开号：US20100239496A1

  公开（公告）日：2010-09-23

  Imaging agents of formula (I) and methods for detecting neurological disorders comprising administering to a patient in need compounds of formula (I) capable of binding to tau proteins and β-amyloid peptides are presented herein. The invention also relates to methods of imaging Aβ and tau aggregates comprising introducing a detectable quantity of pharmaceutical formulation comprising a radiolabeled compound of formula (I) and detecting the labeled compound associated with amyloid deposits and/or tau proteins in a patient. These methods and compositions enable preclinical diagnosis and monitoring progression of AD and other neurological disorders.

  本文提供了一种公式（I）的成像剂和检测神经系统疾病的方法，包括向需要的患者施用能够结合tau蛋白和β-淀粉样肽的公式（I）化合物。该发明还涉及成像Aβ和tau聚集物的方法，包括引入含有公式（I）放射标记化合物的制剂的可检测量，并检测与淀粉样沉积物和/或tau蛋白相关的标记化合物在患者体内的情况。这些方法和组合物使得能够进行临床前诊断和监测阿尔茨海默病和其他神经系统疾病的进展。
• PROTOTYPE SYSTEMS OF THERANOSTIC BIOMARKERS FOR IN VIVO MOLECULAR MANAGEMENT OF CANCER
  申请人：ODYSSEOS Andreani

  公开号：US20160376298A1

  公开（公告）日：2016-12-29

  The present invention relates to a theranostic system comprising a beacon and a compound selected from the group consisting of a quinazoline-based tyrosine kinase inhibitor and a natural product. The theranostic systems have use in the therapy and diagnosis of tyrosine kinase related malignancies.

  本发明涉及一种治疗系统，包括一个信标和从喹唑啉基酪氨酸激酶抑制剂和天然产物组成的化合物中选择的一种。这种治疗系统在酪氨酸激酶相关恶性肿瘤的治疗和诊断中有用。
• Direct alkenylation of 2-substituted azaarenes with carbonyls via C H bond activation using iron-based metal-organic framework Fe 3 O(BPDC) 3 as an efficient heterogeneous catalyst
  作者：Hang T. Dang、Thien N. Lieu、Thanh Truong、Nam T.S. Phan

  DOI：10.1016/j.molcata.2016.04.022

  日期：2016.8

  the transformation significantly. The Fe 3 O(BPDC) 3 exhibited better performance in this transformation then other MOFs such as Fe 3 O(BDC) 3 , Cu 2 (OBA) 2 (BPY), Cu 2 (BDC) 2 (DABCO), Ni 2 (BDC) 2 (DABCO), Zn-MOF-74, and Cu 2 (NDC) 2 (DABCO). The Fe 3 O(BPDC) 3 also exhibited higher catalytic activity than that of several homogeneous catalysts such as FeCl 2 , FeCl 3 , CuCl 2 , Zn(OAc) 2 , Zn(NO

  摘要 由联苯-4,4'-二羧酸与六水合氯化铁在乙酸存在下采用溶剂热法合成多孔结晶金属有机骨架 Fe 3 O(BPDC) 3特点是使用各种不同的技术。Fe 3 O(BPDC) 3 可用作合成2-烯基氮杂芳烃的高效非均相催化剂，通过CH键活化将2-取代的氮杂芳烃与羰基直接烯基化。乙酸作为助催化剂的存在显着加速了转化。Fe 3 O(BPDC) 3 在这种转变中表现出比其他 MOF 更好的性能，例如 Fe 3 O(BDC) 3 、Cu 2 (OBA) 2 (BPY)、Cu 2 (BDC) 2 (DABCO)、Ni 2 ( BDC) 2 (DABCO)、Zn-MOF-74 和 Cu 2 (NDC) 2 (DABCO)。Fe 3 O(BPDC) 3 也表现出比几种均相催化剂如FeCl 2 、FeCl 3 、CuCl 2 、Zn(OAc) 2 、Zn(NO 3 ) 2 和Ni(OAc) 2 更高的催化活性。Fe
• Domino synthesis of protochromic “ON–OFF–ON” luminescent 2-styryl quinolines
  作者：Rahime Cinar、Jan Nordmann、Elena Dirksen、Thomas J. J. Müller

  DOI：10.1039/c3ob27270b

  日期：——

  The microwave-assisted coupling-isomerization reaction (MACIR) opens a straightforward domino access to 2-styryl quinolines in good to excellent yields. The push–pull character of these lumophores can be enhanced by placing a dimethyl amino group as an auxochrome in the para-position of the styryl moiety whereas anti-auxochromes are located in the 6-position of the quinoline part. The optical absorption and emission properties of the compounds were studied in solvents of different polarity and at various pH. The pronounced proto- and solvochromicity of the absorption and emission properties qualify them as luminescent pH sensors with “ON–OFF–ON” emission profiles triggered by pH variation over a broad pH range. The electronic structure of the chromophores is rationalized by DFT calculations.

  微波辅助偶联-异构化反应（MACIR）开辟了一种直接获得 2-苯乙烯基喹啉类化合物的多米诺途径，产量从良好到极佳。通过将二甲基氨基作为辅助色素置于苯乙烯基分子的对位，而将反辅助色素置于喹啉部分的 6 位，可以增强这些发光体的推拉特性。研究人员在不同极性和不同 pH 值的溶剂中对这些化合物的光学吸收和发射特性进行了研究。这些化合物的吸收和发射特性具有明显的原色和溶色性，因此可用作 pH 值发光传感器，其 "ONâOFFâONâ "发射曲线可在广泛的 pH 值范围内由 pH 值变化触发。发色团的电子结构通过 DFT 计算得到了合理解释。
• METHOD FOR PRODUCING ORGANIC COMPOUND
  申请人：DAIKIN INDUSTRIES, LTD.

  公开号：US20210371391A1

  公开（公告）日：2021-12-02

  An object of the present disclosure is to provide a method for producing an organic compound, and a composition. The object is achieved by a method for producing a compound represented by formula (1): wherein X represents —O—, an optionally substituted imino group, or —S—, R 1 represents a hydrogen atom or a hydrocarbyl group optionally having at least one substituent, and R 2 represents a hydrogen atom or a monovalent organic group, or R 1 and R 2 , together with X and one carbon atom respectively adjacent to R 1 and R 2 , may form a heterocyclic ring optionally having at least one substituent, R 3 represents a hydrogen atom or a monovalent organic group, and R 4 represents —CF 2 CH 3 or —CH 2 CHF 2 ; the method including step A of reacting a compound represented by formula (2): wherein the alphabetical symbols are as defined above, with vinylidene fluoride under light irradiation.

  本公开的目的是提供一种生产有机化合物和组合物的方法。该目的通过以下公式（1）所表示的化合物的生产方法实现：其中，X表示—O—、可选择置换的亚胺基团或—S—，R1表示氢原子或可选择具有至少一个取代基的碳氢基团，R2表示氢原子或一价有机基团，或R1和R2分别与X和与R1和R2相邻的一个碳原子形成一个杂环环，该杂环环可选择具有至少一个取代基，R3表示氢原子或一价有机基团，R4表示—CF2CH3或—CH2CHF2；该方法包括步骤A，与乙烯基氟在光照射下反应所示的化合物（2）：其中，字母符号如上所定义。