4-(2,4-difluorophenyl)butanoic acid chloride

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(2,4-difluorophenyl)butanoic acid chloride
• 英文别名: 4-(2,4-Difluorophenyl)butyryl chloride；4-(2,4-difluorophenyl)butanoyl chloride
• 化学式: C₁₀H₉ClF₂O
• 分子量: 218.631
• InChiKey: HSHHGKZDUWHQFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(2,4-difluorophenyl)butanoic acid chloride 在 sodium tetrahydroborate 、 lithium aluminium tetrahydride 、 三氯化铝 、 对甲苯磺酸 、 间氯过氧苯甲酸 作用下， 以 四氢呋喃 、 甲醇 、 二硫化碳 、 氯仿 、 苯 为溶剂， 生成 5,7-difluorotetralol
  参考文献：
  名称：

  Kinetic enzymatic resolution of β-tetralols

  摘要：

  Several substituted beta-tetralols 1a-e and beta-tetralol 2 were successfully resolved using porcine pancreatin in hydrocarbon solvents. All attempts to resolve the substituted beta-tetralols by diasteromeric derivatization have failed. The absolute configuration of the products was established by literature precedence.

  DOI：

  10.1016/0957-4166(95)00180-w
• 作为产物：
  描述：

  1,3-二氟苯 在 palladium on activated charcoal 盐酸 、 sodium hydroxide 、 三氯化铝 、 氯化亚砜 、 amalgamated zinc 、 氢气 、 溶剂黄146 作用下， 反应 51.0h， 生成 4-(2,4-difluorophenyl)butanoic acid chloride
  参考文献：
  名称：

  Synthesis and structure-activity relationships of naphthalene-substituted derivatives of the allylamine antimycotic terbinafine

  摘要：

  Derivatives of the allylamine antimycotic terbinafine (1) with varied substitution at the naphthalene ring system have been prepared, and their antifungal activity has been evaluated. In general, the potency is strongly dependent on the bulkiness of the substituent. Only hydrogen or in some cases fluorine are tolerated as substituents at positions 2-4 and 6-8 of the naphthalene moiety, whereas 5-substituents may be larger in size (F, Cl, Br, Me). Derivatives with fluorine at positions 3, 5, and 7 or chlorine at position 5 showed enhanced activity against yeasts relative to 1. This increase in sensitivity could be intensified by simultaneous introduction of two fluoro substituents at positions 5 and 7. Compound 7q demonstrated 8-to 16-fold improved potency against Aspergillus fumigatus, Candida albicans, and Candida parapsilosis.

  DOI：

  10.1021/jm00071a011

文献信息

• [EN] HYDROXY FORMAMIDE DERIVATIVES AND THEIR USE<br/>[FR] DÉRIVÉS D'HYDROXY FORMAMIDE ET LEUR UTILISATION
  申请人：GLAXOSMITHKLINE IP NO 2 LTD

  公开号：WO2015104684A1

  公开（公告）日：2015-07-16

  Disclosed are compounds having the formula (I): wherein R1, R2 and R3 are as defined herein, and methods of making and using the same, including use as inhibitors of BMP1, TLL1 and/or TLL2 and in treatment of diseases associated with BMP1, TLL1 and/or TLL2 activity.

  揭示了具有以下化学式（I）的化合物：其中R1、R2和R3如本文所定义，并且制备和使用这些化合物的方法，包括用作BMP1、TLL1和/或TLL2的抑制剂以及用于治疗与BMP1、TLL1和/或TLL2活性相关的疾病。
• HYDROXY FORMAMIDE DERIVATIVES AND THEIR USE
  申请人：GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED

  公开号：US20160340328A1

  公开（公告）日：2016-11-24

  Disclosed are compounds having the formula: wherein R1, R2 and R3 are as defined herein, and methods of making and using the same, including use as inhibitors of BMP1, TLL1 and/or TLL2 and in treatment of diseases associated with BMP1, TLL1 and/or TLL2 activity.

  揭示了具有以下公式的化合物：其中R1、R2和R3如本文所定义，并且制备和使用这些化合物的方法，包括用作BMP1、TLL1和/或TLL2的抑制剂以及用于治疗与BMP1、TLL1和/或TLL2活性相关的疾病。
• Synthesis of Mono- and Difluoronaphthoic Acids
  作者：Jayaram R. Tagat、Stuart W. McCombie、Dennis V. Nazareno、Craig D. Boyle、Joseph A. Kozlowski、Samuel Chackalamannil、Hubert Josien、Yuguang Wang、Guowei Zhou

  DOI：10.1021/jo0160322

  日期：2002.2.1

  3, and 4) and the difluoro acids (5, 6, and 7) were prepared by a new, general route which entailed the elaboration of commercial fluorinated phenylacetic acids to 2-(fluoroaryl)glutaric acids with differential ester groups; selective hydrolysis to a mono acid, intramolecular Friedel-Crafts cyclization, and aromatization furnished the target structures. An alternative process to assemble a naphthalene

  芳基羧酰胺是在几种生物活性化合物中发现的有用的结构单元。与苯甲酸对应物不同，萘甲酸的氟化形式相对未知。与最近的项目有关，我们需要可行的几种单氟化和二氟化萘甲酸的合成方法。在本文中，我们描述了5-，6-，7-和8-氟-1-萘羧酸和5,7-，5,8-，6,7-和4,5-二氟-1-萘羧酸的合成酸。通过对硫代中间体的亲电氟化，从相应的5-溴化合物中获得5-氟衍生物1。其余的一氟酸（2、3和4）和二氟酸（5、6和7）是通过新的 通用路线，涉及将商业化的氟化苯基乙酸加工成具有不同酯基的2-（氟芳基）戊二酸；选择性水解为一元酸，分子内Friedel-Crafts环化和芳构化提供了目标结构。还提出了用于二氟酸5和6的组装萘骨架的替代方法。最后，通过适应经典反应，由1，8-二氨基萘迅速制备了4，5-二氟-1-萘甲酸（8）。
• Hydroxy formamide derivatives and their use
  申请人：GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED

  公开号：US10450288B2

  公开（公告）日：2019-10-22

  Disclosed are compounds having the formula: wherein R1, R2 and R3 are as defined herein, and methods of making and using the same, including use as inhibitors of BMP1, TLL1 and/or TLL2 and in treatment of diseases associated with BMP1, TLL1 and/or TLL2 activity.

  所公开的是具有以下式子的化合物 其中 R1、R2 和 R3 如本文所定义，以及制造和使用这些化合物的方法，包括用作 BMP1、TLL1 和/或 TLL2 的抑制剂以及治疗与 BMP1、TLL1 和/或 TLL2 活性有关的疾病。