2-chloromethyl-6-phenoxypyridine | 84641-07-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-chloromethyl-6-phenoxypyridine
• 英文别名: 2-Phenoxy-6-chloromethylpyridine；2-(chloromethyl)-6-phenoxypyridine
• CAS: 84641-07-6
• 化学式: C₁₂H₁₀ClNO
• 分子量: 219.671
• InChiKey: HTPGVWLAVAQOQK-UHFFFAOYSA-N

物化性质

• 沸点：
  329.8±32.0 °C(Predicted)
• 密度：
  1.214±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-chloromethyl-6-phenoxypyridine 在 sodium hydroxide 、 sodium azide 、 氯化铵 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 38.25h， 生成 2-Phenoxy-6-{3-[3-(1H-tetrazol-5-yl)-propoxy]-phenoxymethyl}-pyridine
  参考文献：
  名称：

  Development of a novel series of (2-quinolinylmethoxy)phenyl-containing compounds as high-affinity leukotriene receptor antagonists. 1. Initial structure-activity relationships

  摘要：

  This series of reports describes the development of orally active, highly potent, specific antagonists of the peptidoleukotrienes containing a (2-quinolinylmethoxy)phenyl moiety. Described in this first report are the structure-activity relationships that led to a more than a 20-fold improvement of the potency and selectivity of the initial chemical lead (RG 5901). From this series of compounds, RG 7152 (16) was identified and selected for further evaluation in the clinic as an antiasthmatic agent. Compound 16 competitively inhibits [3H]LTD4 binding to membranes from guinea pig lung (Ki = 38 +/- 6 nM) and the spasmogenic activity of LTC4, LTD4, and LTE4 in parenchymal lung strips from guinea pigs. Unlike the original lead (RG 5901), compound 16 does not inhibit 5-lipoxygenase from guinea pig PMNs. Following oral administration to guinea pigs, 16 blocks LTD4-induced dermal permeability (ED50 = 6.9 mg/kg), LTD4-induced bronchoconstriction (ED50 = 1.1 mg/kg), antigen-induced bronchoconstriction (ED50 = 2.5 mg/kg), and anaphylactic-induced mortality (ED50 = 16 mg/kg). These studies on structure-activity relationships indicate that there is a requirement for an acidic function and the presence of the (2-quinolinylmethoxy)phenyl moiety in a specific geometric arrangement.

  DOI：

  10.1021/jm00166a016
• 作为产物：
  描述：

  (6-phenoxy-pyridin-2-yl)-methanol 、 对甲苯磺酰氯 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 2-chloromethyl-6-phenoxypyridine
  参考文献：
  名称：

  Insecticidal alkenes

  摘要：

  一种化合物的化学式为：CXY.dbd.CH--CR.sup.1 R.sup.2 --CH.sub.2 OCH.sub.2 R，其中X和Y分别选自氢和卤素，R.sup.1和R.sup.2分别是最多含有四个碳原子的低碳烷基，或者与相邻的碳原子一起形成最多含有六个碳原子的环烷基，R代表一个苯氧基或苄基取代的苯基，该苯基可选择性地取代氟。这些化合物可用于对抗昆虫害。

  公开号：

  US04812483A1

文献信息

• Insecticidal ethers
  申请人：Imperial Chemical Industries PLC

  公开号：US04792563A1

  公开（公告）日：1988-12-20

  Insecticidally active compounds of the formula (I): ##STR1## wherein R.sup.4 represents a group selected from those groups represented by R.sup.5 in insecticidally active compounds of formula: ##STR2## R.sup.3 is selected from fluoromethyl and difluoromethyl, and either (a) R.sup.1 and R.sup.2 represent alkyl of one, two, three or four carbon atoms, or (b) R.sup.1 and R.sup.2 taken together with the adjacent carbon atom form a cycloalkyl ring of four, five or six carbon atoms.

  化学式(I)的杀虫活性化合物：其中R.sup.4代表从公式中由R.sup.5代表的那些基团中选择的一个基团。R.sup.3从氟甲基和二氟甲基中选择，且要么(a) R.sup.1和R.sup.2代表碳原子数为一、二、三或四的烷基，要么(b) R.sup.1和R.sup.2与相邻的碳原子一起形成四、五或六个碳原子的环烷基环。
• Certain insecticidal 6-(phenoxy-2-pyridyl)-methyl-neophental ethers
  申请人：Sumitomo Chemical Company, Limited

  公开号：US05006538A1

  公开（公告）日：1991-04-09

  An ether compound represented by the following formula (I), it production and insecticidal compositions containing it as an active ingredient: ##STR1## wherein R.sub.1, represents a halogen atom or a methyl group; R.sub.2 represents a hydrogen atom or a fluorine atom; R.sub.3 represents a hydrogen atom, a halogen atom or a methyl group; R.sub.4 represents a (C.sub.1 -C.sub.3)alkyl group; Y represents an oxygen atom, a sulfur atom, a methylene group or --NH--; and Z represents a nitrogen atom or --CH.dbd..

  一种以以下式子（I）表示的醚类化合物，其生产和含有其作为活性成分的杀虫剂组合物：##STR1## 其中，R.sub.1代表卤素原子或甲基基团；R.sub.2代表氢原子或氟原子；R.sub.3代表氢原子、卤素原子或甲基基团；R.sub.4代表（C.sub.1-C.sub.3）烷基基团；Y代表氧原子、硫原子、亚甲基基团或--NH--；Z代表氮原子或--CH.dbd.。
• Certain phenoxy- or benzyl substituted pyridylmethyloxy-alkenes having
  申请人：Imperial Chemical Industries PLC

  公开号：US04904677A1

  公开（公告）日：1990-02-27

  A compound of the formula: CXY.dbd.CH--CR.sup.1 R.sup.2 --CH.sub.2 OCH.sub.2 R wherein X and Y are each selected from hydrogen and halogen, R.sup.1 and R.sup.2 are each lower alkyl of up to four carbon atoms, or together with the adjacent carbon atom form a cycloalkyl group of up to six carbon atoms, and R represents a phenoxy- or benzyl-substituted phenyl and pyridyl group which may optionally be substituted with fluorine. The compounds are useful for combating insect pests.

  该化合物的化学式为：CXY.dbd.CH--CR.sup.1 R.sup.2 --CH.sub.2 OCH.sub.2 R，其中X和Y分别选自氢和卤素，R.sup.1和R.sup.2分别为低碳链烷基，碳数最多为四个，或与相邻的碳原子形成最多六个碳原子的环烷基，R代表苯氧基或苄基取代的苯和吡啶基，可选地取代氟。这些化合物可用于对抗昆虫害。
• Phenoxy-benzyl ether compounds, compositions containing same, and
  申请人：Sumitomo Chemical Company, Limited

  公开号：US05093373A1

  公开（公告）日：1992-03-03

  An ether compound represented by the following formula (I), it production and insecticidal compositions containing it as an active ingredient: ##STR1## wherein R.sub.1, represents a halogen atom or a methyl group; R.sub.2 represents a hydrogen atom or a fluorine atom; R.sub.3 represents a hydrogen atom, a halogen atom or a methyl group; R.sub.4 represents a (C.sub.1 -C.sub.3)alkyl group; Y represents an oxygen atom, a sulfur atom, a methylene group or --NH--; and Z represents a nitrogen atom or --CH.dbd..

  以下是以以下式子（I）表示的醚化合物，其生产和含有其作为活性成分的杀虫剂组合物： ##STR1## 其中，R.sub.1表示卤原子或甲基基团；R.sub.2表示氢原子或氟原子；R.sub.3表示氢原子、卤原子或甲基基团；R.sub.4表示（C.sub.1-C.sub.3）烷基基团；Y表示氧原子、硫原子、亚甲基基团或--NH--；Z表示氮原子或--CH.dbd.。
• Ether compounds, their production and an insecticidal and/or acaricidal composition containing the same
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0094085A1

  公开（公告）日：1983-11-16

  Ether compounds of the general formula, wherein W represents methine group or nitrogen atom, and (1) when W is the methine group, R1 represents hydrogen atom, fluorine atom, chlorine atom, bromine atom or methyl group, R2 represents hydrogen atom or fluorine atom, R3 and R4 are same or different and represent hydrogen atom, a halogen atom, a C1-4 alkyl, a C1-4 alkoxyl, difluoromethoxy or 2,2,2-trifluoroethoxy group, or represent, taken together, methylenedioxy group, A represents I oxygen atom, methylene group or imino group, and when the A represents oxygen atom or methylene group, X and Y represent, taken together, ethylene group or 1,1-difluoroethylene group and when the A represents imino group, both X and Y represent methyl group or represent, taken together, ethylene j group or 1,1-difluoroethylene group, and (2) when W is the nitrogen atom, both R1 and R2 represent hydrogen atom, R3 and R4 are as defined above, A represents oxygen atom, and both X and Y represent methyl group or represent, taken together, ethylene group or 1,1-difluoroethylene group. The ether compounds of the present invention are useful as an active ingredient of an insecticidal and/or acaricidal composition.

  通式如下的醚化合物 其中 W 代表甲基或氮原子，(1) 当 W 为甲基时、 R1 代表氢原子、氟原子、氯原子、溴原子或甲基，R2 代表氢原子或氟原子，R3 和 R4 相同或不同并代表氢原子、卤素原子、C1-4 烷基、C1-4 烷氧基、二氟甲氧基或 2,2,2-三氟乙氧基，或共同代表亚甲二氧基，A 代表 I 氧原子、亚甲基或亚氨基，当 A 代表氧原子或亚甲基时，X 和 Y 代表、(2) 当 W 为氮原子时，R1 和 R2 均代表氢原子，R3 和 R4 如上定义，A 代表氧原子，X 和 Y 均代表甲基或代表乙烯基或 1，1-二氟乙烯基。 本发明的醚化合物可用作杀虫和/或杀螨剂组合物的活性成分。