7-(p-methoxybenzoyl)pterine | 1224244-74-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 7-(p-methoxybenzoyl)pterine
• 英文别名: 7-(P-Methoxybenzoyl)Pterin；2-amino-7-(4-methoxybenzoyl)-3H-pteridin-4-one
• CAS: 1224244-74-9
• 化学式: C₁₄H₁₁N₅O₃
• 分子量: 297.273
• InChiKey: GEPYFJHDQZCFQC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  120
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-氨基-4-羟基蝶啶 、 4-甲氧基苯甲醛 在 叔丁基过氧化氢 、 硫酸 、 iron(II) sulfate 作用下， 以 水 为溶剂， 反应 0.17h， 生成 7-(p-methoxybenzoyl)pterine
  参考文献：
  名称：

  Acyl radical insertion for the direct formation of new seven-substituted pterin analogs

  摘要：

  A variety of pterin molecules were synthesized via an under-utilized acyl radical insertion, using aldehydes and alpha-keto esters as the acyl source. These reactions gave complete regiospecificity for the 7-isomer, with reaction times ranging in minutes, often with instantaneous product precipitation. This approach led to the construction of new pterin analogs unaccessible via traditional Friedel-Crafts acylation. The compounds were characterized by NMR spectroscopy and high-resolution mass spectroscopy. Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2010.03.008

文献信息

• Acyl radical insertion for the direct formation of new seven-substituted pterin analogs
  作者：Jeff M. Pruet、Jon D. Robertus、Eric V. Anslyn

  DOI：10.1016/j.tetlet.2010.03.008

  日期：2010.5

  A variety of pterin molecules were synthesized via an under-utilized acyl radical insertion, using aldehydes and alpha-keto esters as the acyl source. These reactions gave complete regiospecificity for the 7-isomer, with reaction times ranging in minutes, often with instantaneous product precipitation. This approach led to the construction of new pterin analogs unaccessible via traditional Friedel-Crafts acylation. The compounds were characterized by NMR spectroscopy and high-resolution mass spectroscopy. Published by Elsevier Ltd.