4-acetoxyheptanedioyl dichloride | 131702-54-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-acetoxyheptanedioyl dichloride
• 英文别名: (1,7-Dichloro-1,7-dioxoheptan-4-yl) acetate
• CAS: 131702-54-0
• 化学式: C₉H₁₂Cl₂O₄
• 分子量: 255.098
• InChiKey: IUIBCOLYMIFQLX-UHFFFAOYSA-N

物化性质

• 沸点：
  333.6±37.0 °C(Predicted)
• 密度：
  1.288±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  15
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  60.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-acetoxyheptanedioyl dichloride 在 吡啶 、 盐酸 、 锂硼氢 、 水 、 hydroxide 、 三乙胺 、 三氟乙酸酐 作用下， 以 1,4-二氧六环 、 乙醇 、 二氯甲烷 、 水 、 甲苯 为溶剂， 生成 5-[3-(t-butyldimethylsiloxy)propyl]dihydrofuran-2(3H)-one
  参考文献：
  名称：

  Novel asymmetric synthesis of optically active .delta.- and .gamma.-lactones using a C2-chiral auxiliary

  摘要：

  DOI：

  10.1021/ja00257a046
• 作为产物：
  描述：

  4-酮庚二酸 在 吡啶 、 sodium tetrahydroborate 、 甲酸 、 氯化亚砜 、 硫酸 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 生成 4-acetoxyheptanedioyl dichloride
  参考文献：
  名称：

  Novel asymmetric synthesis of optically active .delta.- and .gamma.-lactones using a C2-chiral auxiliary

  摘要：

  DOI：

  10.1021/ja00257a046

文献信息

• Molecular Brush Having Molten Salt Domain for Fast Ion Conduction
  作者：Masahiro Yoshizawa、Hiroyuki Ohno

  DOI：10.1246/cl.1999.889

  日期：1999.9

  Poly(ethylene oxide) (PEO) derivatives having both vinyl group and imidazolium salt structure on their ends were prepared and polymerized. When molten salt domain was provided by changing chloride anion with bis(trifluoromethanesulfonylimide) anion, excellent ionic conductivity (1.20 × 10−4 Scm−1 at 30 °C) was observed in spite of rubber-like properties.

  制备并聚合了末端同时具有乙烯基和咪唑盐结构的聚环氧乙烷（PEO）衍生物。通过将氯阴离子改为双（三氟甲烷磺酰亚胺）阴离子来提供熔盐域，尽管具有类似橡胶的特性，但还是观察到了极佳的离子导电性（30 °C 时为 1.20 × 10-4 Scm-1）。
• Asymmetric synthesis of 5- and 6-membered lactones from cyclic substrates bearing a C2-chiral auxiliary
  作者：Yukio Yamamoto、Akio Sakamoto、Takaaki Nishioka、Junichi Oda、Yoshimasa Fukazawa

  DOI：10.1021/jo00003a038

  日期：1991.2

  Optically active lactones were synthesized by a novel asymmetric synthesis in which enantiotopic groups remote from a prochiral center were effectively discriminated. The cyclic diamide alcohols bearing a C2-chiral auxiliary, (+)-[1,1'-binaphthyl]-2,2'-diamine (4), were designed and prepared such that the hydroxyl group should attack preferentially at one of the two carbonyl groups. By the catalytic action of trifluoroacetic acid, the substrates 6a,b and 19 were smoothly converted to the lactones 7a (71% de), 7b (97% de), and 20 (> 99% de), the configurations of which were determined to be R, S, and R, respectively. A naturally occurring pheromone, (R)-(+)-5-hexadecanolide (13), was synthesized optically pure from 7b. Transition-state models for the present asymmetric lactonization were constructed according to the stereoelectronic theory proposed by Deslongchamps. The stability of the models was assessed by MM2 calculation, and the direction of asymmetric induction thus calculated coincided with the experimental results.
• YAMAMOTO, YUKIO;SAKAMOTO, AKIO;NISHIOKA, TAKAAKI;ODA, JUNICHI;FUKAZAWA, Y+, J. ORG. CHEM., 56,(1991) N, C. 1112-1119
  作者：YAMAMOTO, YUKIO、SAKAMOTO, AKIO、NISHIOKA, TAKAAKI、ODA, JUNICHI、FUKAZAWA, Y+

  DOI：——

  日期：——