5'-OH-dGi-BupoCNEdGi-Bu-3'-O-Lev | 863507-20-4

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 5'-OH-dGi-BupoCNEdGi-Bu-3'-O-Lev
• 英文别名: 5'-OH-dG^i-Bupo_CNEdG^i-Bu-3'-O-Lev
• CAS: 863507-20-4
• 化学式: C₃₆H₄₆N₁₁O₁₄P
• 分子量: 887.8
• InChiKey: BMGOMRICTFCVST-NCDRMDBLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.73
• 重原子数：
  62.0
• 可旋转键数：
  19.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  335.95
• 氢给体数：
  5.0
• 氢受体数：
  21.0

反应信息

• 作为反应物：
  描述：

  5'-OH-dGi-BupoCNEdGi-Bu-3'-O-Lev 、 5’-(4,4’-二甲氧基三苯基)-3’-脱氧胸苷 2’-(2-氰乙基-N,N-二异丙基)亚磷酰胺 以7.5 g的产率得到5'-OH-dTpo_CNEdG^i-Bupo_CNEdG^i-Bu-3'-O-Lev
  参考文献：
  名称：

  High-Yield Solution-Phase Synthesis of Di- and Trinucleotide Blocks Assisted by Polymer-Supported Reagents

  摘要：

  [GRAPHICS]A new solution-phase phosphoramidite approach is reported for oligonucleotide synthesis employing recyclable solid-supported reagents. It uses polyvinyl pyridinium tosylate as the activator of a nucleoside-3'-O-phosphoramidite in the coupling step with a 5'-OH nucleoside or dinucleotide. The resulting phosphite triester was either sulfurized or oxidized using polystyrene-bound trimethylammonium tetrathionate or periodiate. This method avoids complicated purification steps, as excess reagents are easily removed by filtration.

  DOI：

  10.1021/ol0511777
• 作为产物：
  描述：

  N²-isobutyryl-3'-O-levulinyl-2'-deoxyguanosine 、 5'-O-dimethoxytrityl-N2-isobutyryl-2'-deoxyguanosine-3'-O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite 以7.03 g的产率得到5'-OH-dGi-BupoCNEdGi-Bu-3'-O-Lev
  参考文献：
  名称：

  High-Yield Solution-Phase Synthesis of Di- and Trinucleotide Blocks Assisted by Polymer-Supported Reagents

  摘要：

  [GRAPHICS]A new solution-phase phosphoramidite approach is reported for oligonucleotide synthesis employing recyclable solid-supported reagents. It uses polyvinyl pyridinium tosylate as the activator of a nucleoside-3'-O-phosphoramidite in the coupling step with a 5'-OH nucleoside or dinucleotide. The resulting phosphite triester was either sulfurized or oxidized using polystyrene-bound trimethylammonium tetrathionate or periodiate. This method avoids complicated purification steps, as excess reagents are easily removed by filtration.

  DOI：

  10.1021/ol0511777