(S)-1,1-difluoro-2-nonyn-4-ol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (S)-1,1-difluoro-2-nonyn-4-ol
• 英文别名: (4S)-1,1-difluoronon-2-yn-4-ol
• 化学式: C₉H₁₄F₂O
• 分子量: 176.206
• InChiKey: BAGMPDUVBYXSDJ-QMMMGPOBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (S)-1,1-difluoro-2-nonyn-4-ol 在 Lindlar's catalyst 氢气 作用下， 以 正己烷 为溶剂， 生成 (S)-(Z)-1,1-difluoro-2-nonen-4-ol
  参考文献：
  名称：

  Optically active propargylic and allylic alcohols with a difluoromethyl group at the terminal carbon

  摘要：

  Enantioselective esterification of oc-substituted propargylic alcohols was found to proceed very smoothly in the presence of a catalytic amount of lipase (Nobozym 435) to yield the corresponding (R)-alcohols and (S)-acetates with high enantiomeric excess. Further, the preparation of optically active propargylic and allylic alcohols with a difluoromethyl group at the terminal carbon is described. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0957-4166(97)00473-4
• 作为产物：
  描述：

  (S)-tert-butyldimethyl(oct-1-yn-3-yloxy)silane 在 正丁基锂 、 对甲苯磺酸 作用下， 以 甲醇 为溶剂， 反应 2.0h， 生成 (S)-1,1-difluoro-2-nonyn-4-ol
  参考文献：
  名称：

  Optically active propargylic and allylic alcohols with a difluoromethyl group at the terminal carbon

  摘要：

  Enantioselective esterification of oc-substituted propargylic alcohols was found to proceed very smoothly in the presence of a catalytic amount of lipase (Nobozym 435) to yield the corresponding (R)-alcohols and (S)-acetates with high enantiomeric excess. Further, the preparation of optically active propargylic and allylic alcohols with a difluoromethyl group at the terminal carbon is described. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0957-4166(97)00473-4

文献信息

• Optically active propargylic and allylic alcohols with a difluoromethyl group at the terminal carbon
  作者：Ling Xiao、Tomoya Kitazume

  DOI：10.1016/s0957-4166(97)00473-4

  日期：1997.11

  Enantioselective esterification of oc-substituted propargylic alcohols was found to proceed very smoothly in the presence of a catalytic amount of lipase (Nobozym 435) to yield the corresponding (R)-alcohols and (S)-acetates with high enantiomeric excess. Further, the preparation of optically active propargylic and allylic alcohols with a difluoromethyl group at the terminal carbon is described. (C) 1997 Elsevier Science Ltd.