(E)-3-(2-羟基-4-甲氧基苯基)丙烯酸 | 38489-77-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 中文名称: (E)-3-(2-羟基-4-甲氧基苯基)丙烯酸
• 英文名称: trans-2-Hydroxy-4-methoxyzimtsaeure
• 英文别名: 3-(2-Hydroxy-4-methoxy-phenyl)-acrylic acid；(E)-3-(2-hydroxy-4-methoxyphenyl)prop-2-enoic acid
• CAS: 38489-77-9
• 化学式: C₁₀H₁₀O₄
• 分子量: 194.187
• InChiKey: IKNVEOZIOFMENG-HWKANZROSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (E)-3-(2-羟基-4-甲氧基苯基)丙烯酸 在 4-二甲氨基吡啶 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 作用下， 以 四氢呋喃 、 水 、 乙腈 为溶剂， 反应 2.84h， 生成 7-甲氧基香豆素
  参考文献：
  名称：

  Enzyme-Catalyzed Conversion of Chemical Structures on the Surface of Gold Nanorods

  摘要：

  For developing metal nanoparticles of which surface chemical structures could be altered by enzymes in the cells, functional linkers caged by coumaric acids have been synthesized. Synthesized gold nanorod (GNR) conjugates possessing coumaric acid precursors underwent (porcine liver) esterase-catalyzed hydrolysis on their surface to afford GNRs coated with amino-functionalized polyethylene glycol and fluorescent coumarins as reporter molecules for monitoring the conversion. The chemical structural conversion on the GNR surfaces was successfully observed inside cells by fluorescence microscopy when GNR conjugates were incubated with tumor cells.

  DOI：

  10.1021/bc3005599
• 作为产物：
  描述：

  7-甲氧基香豆素 在 氢氧化钾 、 sodium sulfite 作用下， 生成 (E)-3-(2-羟基-4-甲氧基苯基)丙烯酸
  参考文献：
  名称：

  Optische Untersuchungen an Cumarinen Mitteilung: Die Ultraviolettabsorption vor Mono-methoxy-cumarinen und ihren Abkömmlingen

  摘要：

  DOI：

  10.1002/ardp.19572901003

文献信息

• Die Konstitution des Athamantins und des Oroselols
  作者：O. Halpern、P. Waser、H. Schmid

  DOI：10.1002/hlca.19570400329

  日期：——

  1. Das Cumarin Athamantin wurde der Einwirkung von Alkalien und Lithiumaluminiumhydrid unterworfen; die hierbei auftretenden Reaktionsprodukte wurden in ihrer Struktur bestimmt. Die erhaltenen Resultate führten zur Formel I für den Naturstoff.

  1. Das Cumarin Athamantin werde der Einwirkung von Alkalien和Unterworfen氢化铝锂；在最佳Struttur中找到Reaktionsprodukte wurden。Der erhaltenen最终形成了Naturstoff的Formel我。
• Design, synthesis and biological evaluation of novel trimethylpyrazine-2-carbonyloxy-cinnamic acids as potent cardiovascular agents
  作者：Hongfei Chen、Guoning Li、Peng Zhan、Hong Li、Shouxun Wang、Xinyong Liu

  DOI：10.1039/c4md00022f

  日期：——

  A series of novel trimethylpyrazine-2-carbonyloxy-cinnamic acids and esters were designed, synthesized and evaluated for their inhibitory effect on adenosine diphosphate (ADP)-induced platelet aggregation in vitro and also assayed for their protective effect against hydrogen peroxide (H2O2)-induced oxidative damage on Ea.hy926 cells. The results showed that many compounds exhibited high activity in one or both of the assays, of which, compound F′10 displayed the highest protective effect on the proliferation of the damaged Ea.hy926 cells (EC50 = 1.7 μM), presenting almost 40 times higher potency than that of lipoic acid, and compound F3 was the most active anti-platelet aggregation agent with IC50 = 9.6 μM, comparable to that of clopidogrel. The structure–activity relationships of these compounds were also discussed.

  研究人员设计、合成了一系列新型三甲基吡嗪-2-甲酰氧基肉桂酸及其酯类化合物，并评估了它们对体外二磷酸腺苷（ADP）诱导的血小板聚集的抑制作用，同时还检测了它们对过氧化氢（H2O2）诱导的 Ea.hy926 细胞氧化损伤的保护作用。结果表明，许多化合物在一种或两种试验中都表现出较高的活性，其中化合物 F′10 对受损 Ea.hy926 细胞的增殖具有最高的保护作用（EC50 = 1.7 μM），其效力比硫辛酸高近 40 倍；化合物 F3 是最活跃的抗血小板聚集剂，其 IC50 = 9.6 μM，与氯吡格雷相当。此外，还讨论了这些化合物的结构-活性关系。
• Base generator
  申请人：Katayama Mami

  公开号：US08476444B2

  公开（公告）日：2013-07-02

  A photosensitive resin composition which is excellent in resolution, low in cost, and usable in a wide range of structures of polymer precursors each of which is reacted into a final product by a basic substance or by heating in the presence of a basic substance. The photosensitive resin composition includes a base generator which has a specific structure and generates a base by exposure to electromagnetic radiation and heating, and a polymer precursor which is reacted into a final product by the base generator and by a basic substance or by heating in the presence of a basic substance.

  这是一种光敏树脂组合物，具有高分辨率、低成本和可用于各种聚合物前体结构的优点，每种聚合物前体通过碱性物质反应或在碱性物质存在下加热反应成为最终产品。光敏树脂组合物包括一种具有特定结构的碱发生剂，通过电磁辐射和加热产生碱性物质，以及一种聚合物前体，通过碱发生剂和碱性物质反应或在碱性物质存在下加热反应成为最终产品。
• BASE GENERATOR, PHOTOSENSITIVE RESIN COMPOSITION, PATTERN FORMING MATERIAL COMPRISING THE PHOTOSENSITIVE RESIN COMPOSITION, AND PATTERN FORMING METHOD AND ARTICLE USING THE PHOTOSENSITIVE RESIN COMPOSITION
  申请人：Katayama Mami

  公开号：US20110086311A1

  公开（公告）日：2011-04-14

  A photosensitive resin composition which is excellent in resolution, low in cost, and usable in a wide range of structures of polymer precursors each of which is reacted into a final product by a basic substance or by heating in the presence of a basic substance. The photosensitive resin composition includes a base generator which has a specific structure and generates a base by exposure to electromagnetic radiation and heating, and a polymer precursor which is reacted into a final product by the base generator and by a basic substance or by heating in the presence of a basic substance.

  一种光敏树脂组合物，具有分辨率优良、成本低廉和可用于一系列聚合物前体结构的特点，其中每种聚合物前体都可以通过碱性物质或在碱性物质的存在下加热反应成为最终产物。该光敏树脂组合物包括一种具有特定结构并通过电磁辐射和加热产生碱性物质的基发生剂，以及一种聚合物前体，该聚合物前体通过基发生剂和碱性物质或在碱性物质的存在下加热反应成为最终产物。
• NEGATIVE TYPE PHOTOSENSITIVE SILOXANE COMPOSITION AND METHODS FOR PRODUCING CURED FILM AND ELECTRONIC DEVICE USING THE SAME
  申请人：Merck Patent GmbH

  公开号：US20200333708A1

  公开（公告）日：2020-10-22

  [Object] To provide a negative type photosensitive siloxane composition capable of forming a cured film excellent in heat resistance and critical thickness for cracking [Means] The present invention provides a negative type photosensitive siloxane composition comprising : a polysiloxane containing silanol in a specific content, a particular photo base generator, and a solvent. The content of silanol is measured by FT-IR.

  【目标】提供一种负型光敏硅氧烷组合物，能形成热稳定性和临界厚度优异的固化膜。 【方法】本发明提供一种负型光敏硅氧烷组合物，包括：含有特定硅醇含量的聚硅氧烷、特定的光碱发生剂和溶剂。硅醇的含量由FT-IR测量。