1-cyclopropyl-4-methyl-2E-penten-1-one | 128540-79-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-cyclopropyl-4-methyl-2E-penten-1-one
• 英文别名: 1-cyclopropyl-4-methyl-pent-2t-en-1-one；1-Cyclopropyl-4-methyl-pent-2t-en-1-on；(E)-1-cyclopropyl-4-methylpent-2-en-1-one
• CAS: 128540-79-4
• 化学式: C₉H₁₄O
• 分子量: 138.21
• InChiKey: CVCLRZKWRYDOEI-ZZXKWVIFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-cyclopropyl-4-methyl-2E-penten-1-one 在 sodium tetrahydroborate 、 三甲基氯硅烷 、 cerium(III) chloride 、 zinc(II) chloride 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 10.42h， 生成 1-chloro-7-methyl-3E,5E-octadiene
  参考文献：
  名称：

  Simple synthesis of?-silyloxyacylcyclopropanes and the homoallyl rearrangement of cyclopropylcarbinols by the action of trimethylsilyl halides in the presence of zinc halides

  摘要：

  The ZnCl2 catalyzed condensation of 1-trimethylsilyloxyvinylcyclopropane with aldehydes and ketones gave beta-silyloxyacylcyclopropanes, which were converted by the action of TsOH in boiling benzene into 1-cyclopropyl-2E-alken-1-ones. Reduction of the latter gave saturated and allyl cyclopropylcarbinols, which by means of Me3SiX and catalytic amounts of ZnX2 (X = Cl, Br) were highly selectively converted into the corresponding linear mono- and dienic E-homoallyl halides. The sequence of reactions that was worked out provided an effective synthesis of 3E-dodecenyl acetate, a sex pheromone of the sugar beet moth.

  DOI：

  10.1007/bf00958248
• 作为产物：
  描述：

  1-环丙基-1-(三甲基硅烷基氧基)-乙烯 在 对甲苯磺酸 、 zinc(II) chloride 作用下， 以 二氯甲烷 、 苯 为溶剂， 反应 2.0h， 生成 1-cyclopropyl-4-methyl-2E-penten-1-one
  参考文献：
  名称：

  Simple synthesis of?-silyloxyacylcyclopropanes and the homoallyl rearrangement of cyclopropylcarbinols by the action of trimethylsilyl halides in the presence of zinc halides

  摘要：

  The ZnCl2 catalyzed condensation of 1-trimethylsilyloxyvinylcyclopropane with aldehydes and ketones gave beta-silyloxyacylcyclopropanes, which were converted by the action of TsOH in boiling benzene into 1-cyclopropyl-2E-alken-1-ones. Reduction of the latter gave saturated and allyl cyclopropylcarbinols, which by means of Me3SiX and catalytic amounts of ZnX2 (X = Cl, Br) were highly selectively converted into the corresponding linear mono- and dienic E-homoallyl halides. The sequence of reactions that was worked out provided an effective synthesis of 3E-dodecenyl acetate, a sex pheromone of the sugar beet moth.

  DOI：

  10.1007/bf00958248

文献信息

• 1-SUBSTITUTED, 4-(SUBSTITUTED PHENOXYMETHYL)-1,2,3-TRIAZOLE COMPOUNDS WITH ANTIFUNGAL PROPERTIES AND METHODS FOR PREPARATION THEREOF
  申请人：FDC LIMITED

  公开号：US20160009692A1

  公开（公告）日：2016-01-14

  Disclosed herein are novel antifungal compounds of Formula 1, containing 1-substituted, 4-(substituted phenoxy-methyl)-1,2,3-triazole moieties coupled to a core having triazole ring, (un)substituted phenyl ring and tertiary alcoholic functionality, and pharmaceutically acceptable salts thereof; methods for preparing these compounds; and pharmaceutical preparations containing these novel compounds for prevention and treatment of fungal infections.

  本文披露了一种新型的抗真菌化合物，式子为1，包含1-取代，4-(取代苯氧甲基)-1,2,3-三唑基团偶联到具有三唑环、(未)取代苯环和三级醇功能的核心上，以及其药学上可接受的盐；制备这些化合物的方法；和含有这些新型化合物的药物制剂，用于预防和治疗真菌感染。
• Cyclopropanes. VII.¹ 2-Phenylbicyclopropyl
  作者：Lee Irvin Smith、Edgar R. Rogier

  DOI：10.1021/ja01152a083

  日期：1951.8
• CHESKIS, B. A.;IVANOVA, N. M.;MOISEENKOV, A. M.;NEFEDOV, O. M., IZV. AN CCCP. CEP. XIM.,(1990) N, S. 2025-2036
  作者：CHESKIS, B. A.、IVANOVA, N. M.、MOISEENKOV, A. M.、NEFEDOV, O. M.

  DOI：——

  日期：——
• US9540350B2
  申请人：——

  公开号：US9540350B2

  公开（公告）日：2017-01-10