1-(aminomethyl)-5,6-dihydroxyphthalan hydrobromide | 96142-92-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异香豆素
• 英文名称: 1-(aminomethyl)-5,6-dihydroxyphthalan hydrobromide
• 英文别名: 1-aminomethyl-5,6-dihydroxy-phthalan hydrobromide；1-(Aminomethyl)-1,3-dihydro-2-benzofuran-5,6-diol;hydrobromide
• CAS: 96142-92-6
• 化学式: BrH*C₉H₁₁NO₃
• 分子量: 262.103
• InChiKey: WTVLHRHWPGREMK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.21
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  75.7
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4,5-二甲氧基邻苯二甲酸 在 palladium on activated charcoal sodium hydroxide 、 硼烷四氢呋喃络合物 、 氢溴酸 、 氢气 作用下， 以 四氢呋喃 为溶剂， 反应 12.5h， 生成 1-(aminomethyl)-5,6-dihydroxyphthalan hydrobromide
  参考文献：
  名称：

  Conformationally defined adrenergic agents. 4. 1-(Aminomethyl)phthalans: synthesis and pharmacological consequences of the phthalan ring oxygen atom

  摘要：

  The synthesis of a series of 1-(aminomethyl)phthalans 1b is reported. The radioligand binding to alpha 1- and alpha 2-receptors and the in vitro pharmacology in alpha 1 (rabbit aorta) and alpha 2 (phenoxybenzamine-pretreated dog saphenous vein) tissues were determined and were compared to the activity of the corresponding 1-(aminomethyl)indans. The activity of this series of phthalans was found to be consistent with the electrostatic repulsion hypothesis that was used to design the parent indan (ERBCOP) compounds. The effect of the phthalan ring oxygenation was to somewhat improve alpha 1-receptor potency relative to the 6-ERBCOP indans without having a general effect on the alpha 2-receptor potency. We conclude from the overall pattern of activity that while the norepinephrine type beta-hydroxyl group may be beneficial for binding to the alpha 1-adrenoceptor, it is not required for strong binding to or full stimulation of the alpha 2-adrenergic receptor, provided that the conformational mobility associated with the phenylethylamine is restricted and maintained in a favorable conformation for receptor interaction.

  DOI：

  10.1021/jm00384a030

文献信息

• DEBERNARDIS J. F.; ARENDSEN D. L.; KYNCL J. J.; KERKMAN D. J., J. MED. CHEM., 30,(1987) N 1, 178-184
  作者：DEBERNARDIS J. F.、 ARENDSEN D. L.、 KYNCL J. J.、 KERKMAN D. J.

  DOI：——

  日期：——
• US4500543A
  申请人：——

  公开号：US4500543A

  公开（公告）日：1985-02-19
• Conformationally defined adrenergic agents. 4. 1-(Aminomethyl)phthalans: synthesis and pharmacological consequences of the phthalan ring oxygen atom
  作者：John F. DeBernardis、David L. Arendsen、John J. Kyncl、Daniel J. Kerkman

  DOI：10.1021/jm00384a030

  日期：1987.1

  The synthesis of a series of 1-(aminomethyl)phthalans 1b is reported. The radioligand binding to alpha 1- and alpha 2-receptors and the in vitro pharmacology in alpha 1 (rabbit aorta) and alpha 2 (phenoxybenzamine-pretreated dog saphenous vein) tissues were determined and were compared to the activity of the corresponding 1-(aminomethyl)indans. The activity of this series of phthalans was found to be consistent with the electrostatic repulsion hypothesis that was used to design the parent indan (ERBCOP) compounds. The effect of the phthalan ring oxygenation was to somewhat improve alpha 1-receptor potency relative to the 6-ERBCOP indans without having a general effect on the alpha 2-receptor potency. We conclude from the overall pattern of activity that while the norepinephrine type beta-hydroxyl group may be beneficial for binding to the alpha 1-adrenoceptor, it is not required for strong binding to or full stimulation of the alpha 2-adrenergic receptor, provided that the conformational mobility associated with the phenylethylamine is restricted and maintained in a favorable conformation for receptor interaction.