| 439857-80-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 439857-80-4
• 化学式: C₂₄H₅₄O₅Si₃
• 分子量: 506.946
• InChiKey: VHVADAZEKUCMRU-BAHGYDIPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.89
• 重原子数：
  32.0
• 可旋转键数：
  15.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  57.15
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  在 三氟甲磺酸三甲基硅酯 、 3 A molecular sieve 、 sodium hydride 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Synthetic replacement of the methylamino group of neocarzinostatin chromophore with hydroxyl prohibits thiol activation in organic solvents and diminishes the rate and efficiency of thiol-promoted DNA cleavage in water

  摘要：

  A synthesis of the neocarzinostatin chromophore analog 2, in which the 2'-N-methylamino group of the natural product has been replaced by a hydroxyl group, is described. Thiol addition experiments in organic solvents and DNA-cleavage studies in aqueous solution are also described, and provide further support for the proposed participation of the carbohydrate methylamino group in neocarzinostatin activation. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00880-1
• 作为产物：
  描述：

  D-Fucose 在 palladium dihydroxide 吡啶 、 氢气 、 乙酰氯 作用下， 以 二氯甲烷 、 乙酸乙酯 为溶剂， 生成
  参考文献：
  名称：

  Synthetic replacement of the methylamino group of neocarzinostatin chromophore with hydroxyl prohibits thiol activation in organic solvents and diminishes the rate and efficiency of thiol-promoted DNA cleavage in water

  摘要：

  A synthesis of the neocarzinostatin chromophore analog 2, in which the 2'-N-methylamino group of the natural product has been replaced by a hydroxyl group, is described. Thiol addition experiments in organic solvents and DNA-cleavage studies in aqueous solution are also described, and provide further support for the proposed participation of the carbohydrate methylamino group in neocarzinostatin activation. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00880-1