N-1H-苯并[d]咪唑-1-基-乙酰胺 | 40995-18-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 中文名称: N-1H-苯并[d]咪唑-1-基-乙酰胺
• 英文名称: 1-(acetamido)benzimidazole
• 英文别名: 1-acetylaminobenzimidazole；1-(N-acetylamino)benzimidazole；N-benzoimidazol-1-yl-acetamide；Acetamide,N-1H-benzo[D]imidazol-1-YL-；N-(benzimidazol-1-yl)acetamide
• CAS: 40995-18-4
• 化学式: C₉H₉N₃O
• mdl: MFCD02947156
• 分子量: 175.19
• InChiKey: WFAQRNLVTGMJGE-UHFFFAOYSA-N

物化性质

• 密度：
  1.27±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.111
• 拓扑面积：
  46.9
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  N-1H-苯并[d]咪唑-1-基-乙酰胺 在 盐酸 、 sulfur 作用下， 反应 3.5h， 生成 1-氨基-1,3-二氢-2H-苯并咪唑-2-硫酮
  参考文献：
  名称：

  1-(烷基氨基)-和1-(二烷基氨基)苯并咪唑啉-2-硫酮的合成

  摘要：

  与 1-氨基苯并咪唑不同，1-烷基氨基苯并咪唑在与硫融合时被硫醇化而不消除 N-氨基，产生以前未知的 1-(烷基氨基)苯并咪唑啉-2-硫酮。这些化合物可以通过 1-烷基乙酰氨基苯并咪唑的硫醇化作用，随后水解消除乙酰基，以制备规模更方便地获得。当 1-（二烷基氨基）苯并咪唑与硫稠合时，它们会转化为 1-（二烷基氨基）苯并咪唑啉-2-硫酮。通过在碱性介质中用碘甲烷对 1-(甲氨基)-和 1-(二乙氨基)苯并咪唑啉-2-硫酮进行烷基化，制备相应的 2-(甲硫基)苯并咪唑。

  DOI：

  10.1007/bf00696720

文献信息

• Benzimidazole and indole derivatives as CRF receptor modulators
  申请人：——

  公开号：US20030055037A1

  公开（公告）日：2003-03-20

  Benzimidazole and indole derivatives that act as selective modulators of CRF 1 receptors are provided. These compounds are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds of the invention are also useful as probes for the localization of CRF receptors and as standards in assays for CRF receptor binding. Methods of using the compounds in receptor localization studies are given.

  提供作为CRF 1受体选择性调节剂的苯并咪唑和吲哚衍生物。这些化合物在治疗多种中枢神经系统和外周疾病方面具有用途，特别是应激、焦虑、抑郁、心血管疾病和进食障碍。还提供了治疗这些疾病的方法以及包装的药物组合物。发明的化合物还可用作CRF受体定位的探针以及CRF受体结合测定的标准。提供了使用这些化合物进行受体定位研究的方法。
• Composition and method for hydrophilic treatment of aluminium or aluminium alloy, and use of the composition
  申请人：NIHON PARKERIZING CO., LTD.

  公开号：EP0937757A1

  公开（公告）日：1999-08-25

  Here are provided a composition for hydrophilic treatment of aluminum or aluminum alloy which can form film having persistent corrosion resistance and hydrophilicity and not generating odor, a method for hydrophilic treatment, and use thereof for hydrophilic treatment. Namely, provided by the invention are a composition for hydrophilic treatment of aluminum or an aluminum alloy which comprises (P1) a water - soluble polymer having as a constitution unit monomer(s) (I) represented by the formula wherein, R1 represents a hydrogen atom or a methyl group, and R2 and R3 are the same or different, and each represent a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, a benzyl group or a hydroxyalkyl group having 2 or 3 carbon atoms, and obtained by homopolymerization or copolymerization of the monomer(s) (I), (A) a water - soluble trivalent chromium compound, (B) a water - soluble zirconium compound or titanium compound, and, if necessary, further water, and wherein the mutual rate of P1, A and B is such that, based on 100 weight parts of the solid matter of P1, A is 0.01 to 70 weight parts and B is 0.001 to 70 weight parts, a method for hydrophilic treatment using it, and use thereof for hydrophilic treatment.

  本发明提供了一种可形成具有持久耐腐蚀性和亲水性且不产生气味的薄膜的铝或铝合金亲水处理组合物、一种亲水处理方法及其在亲水处理中的用途。 也就是说，本发明提供了一种用于铝或铝合金亲水处理的组合物，其中包括 (P1) 一种水溶性聚合物，其构成单元为由式（I）代表的单体 其中，R1 代表氢原子或甲基，R2 和 R3 相同或不同，各自代表氢原子、具有 1 至 4 个碳原子的烷基、苄基或具有 2 或 3 个碳原子的羟烷基、 并通过单体（I）的均聚或共聚得到、 (A) 水溶性三价铬化合物、 (B) 可溶于水的锆化合物或钛化合物，必要时再加入水、 其中 P1、A 和 B 的相互比例为，以 100 重量份的 P1 固体物质为基准，A 为 0.01 至 70 重量份，B 为 0.001 至 70 重量份，使用它进行亲水处理的方法，及其在亲水处理中的用途。
• Syntheses and Properties of 1-Methyl-3-phenylaminobenzimidazolium Salts, Models of DNA Adducts of N7-Arylaminodeoxyguanosinium Salt
  作者：Toyo Kaiya、Tomoko Fujiwara、Kohfuku Kohda

  DOI：10.1021/tx0000724

  日期：2000.10.1

  When arylaminating carcinogens are administered to cells, they mainly generate the C8-arylamino-2'-deoxyguanosine adduct in DNA. A mechanism for this was proposed in which N7-arylaminated 2'-deoxyguanosine acts as an intermediate; however, it remained unclear whether this is actually the case. To elucidate the mechanisms involved in the generation of this adduct, a series of 5-substituted 1-methylbenzimidazole derivatives were used as models of the imidazole moiety of 2'-deoxyguanosine. Syntheses of a series of 5-substituted (CH3, H, F, CF3, or NO2) 1-methyl-3-phenylaminobenzimidazolium salts (7) and their related compounds were carried out, and the chemical characteristics of these products were examined. Keating compound 7 at 80 degreesC for 48 h in H2O/MeOH provided 5-substituted 1-methyl-2-oxo-2,3-dihydrobenzimidazoles but only when this compound contained a CF3 or NO2 substituent. Compound 7 decomposed in alkaline media, and its rate of decomposition increased when this compound had a stronger electron-withdrawing substituent. The product obtained under these conditions was 4-substituted N-1-methyl-2-phenylazoaniline. On the other hand, when 1-methyl-3-(4-nitrophenylamino)benzimidazolium salt was treated under the same conditions as described above, it generated, a demethylated product, 1-(4-nitrophenylamino)benzimidazole, when heated in H2O/MeOH and N-1-formyl-N-1-methyl-2-phenylazoaniline when treated in alkaline media. When the chemical characteristics of 3-phenylamino and 3-amino groups were compared using 3-substituted 1-methyl-5-(trifluoromethyl)benzimidazole the 3-phenylamino derivative was found to be more reactive.
• ——
  作者：O. V. Dyablo、M. E. Kletskii、A. F. Pozharskii、E. V. Yakovleva

  DOI：10.1023/a:1020973514280

  日期：——
• BENZIMIDAZOLE AND INDOLE DERIVATIVES AS CRF RECEPTOR MODULATORS
  申请人：Neurogen Corporation

  公开号：EP1322620A1

  公开（公告）日：2003-07-02