ilexgenin B

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: ilexgenin B
• 英文别名: (1R,2S,4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-1,10-dihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
• 化学式: C₃₀H₄₈O₄
• 分子量: 472.709
• InChiKey: ZZTYPLSBNNGEIS-NWKLQIEGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  34
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-O-β-D-glucopyranosyl-(1→3)-α-L-arabinopyranosyl-ilexgenin B 在 盐酸 作用下， 以 水 为溶剂， 反应 3.0h， 生成 ilexgenin B
  参考文献：
  名称：

  Triterpenoid saponins from Ilex mamillata C.Y. Wu ex C.J. Tseng

  摘要：

  Two new triterpenoid saponins, ilemaminosides A and B (1 and 2) along with six known saponins (3-8) were isolated from 70% ethanolic extract of the leaves of Ilex mamillata C.Y. Wu ex C.J. Tseng. The new saponins were characterised as 3-O-alpha-L-arabinopyranosyl-ilexgenin B (1) and 3-O-beta-D-glucopyranosyl-(1 -> 3)-alpha-L-arabinopyranosyl-ilexgenin B (2). The structures of compounds 1 and 2 were elucidated on the basis of the chemical and spectroscopic methods, and the structures of known compounds were identified by comparison of their spectroscopic data with those reported in the literature. The compounds showed inhibitory activities in anti-inflammatory assay in vitro with IC50 values in the range 25.37-38.33 mu gmL(-1).

  DOI：

  10.1080/14786419.2011.636744

文献信息

• Triterpenoid saponins from the leaves of Ilex latifolia
  作者：Ouyang Ming-An、Wang Han-Qing、Liu Yu-Qing、Yang Chong-Ren

  DOI：10.1016/s0031-9422(97)00175-1

  日期：1997.8

  Five new triterpenoid saponins latifolosides A-E were isolated from the leaves of Ilex latifolia, along with a known compound. Their chemical structures have been elucidated on the basis of the chemical and spectral methods. (C) 1997 Elsevier Science Ltd. All rights reserved.

  从阔叶冬青的叶子中分离出五种新的三萜皂苷 AE，以及一种已知化合物。它们的化学结构已在化学和光谱方法的基础上得到阐明。(C) 1997 Elsevier Science Ltd。保留所有权利。
• Triterpenoid saponins from Ilex latifolia
  作者：Ming-An Ouyang、Yu-Qing Liu、Han-Qing Wang、Chong-Ren Yang

  DOI：10.1016/s0031-9422(98)00164-2

  日期：1998.12

  Three new triterpenoid saponins, latifolosides F, G, H were isolated from the leaves of Ilex latifolia. Their structures were elucidated on the basis of chemical and spectral evidence. Latifoloside F was determined to be 3-O-[alpha-L-rhamnopyranosyl(1-2)]-[beta-D-glucopyranosyl(1-3)-]- alpha-L-arabinopyranosyl ilexgenin B 28-O-[alpha-L-rhamnopyranosyl(1-2)]-beta-D-glucopyranoside. Latifoloside G was

  从阔叶冬青的叶子中分离出三种新的三萜皂苷，阔叶苷F、G、H。根据化学和光谱证据阐明了它们的结构。Latifoloside F 被确定为 3-O-[α-L-吡喃鼠李糖基 (1-2)]-[β-D-吡喃葡萄糖基 (1-3)-]-α-L-阿拉伯吡喃糖苷 B 28-O-[α -L-吡喃鼠李糖基(1-2)]-β-D-吡喃葡萄糖苷。Latifoloside G 是 3-O-[α-L-吡喃鼠李糖基(1-2)]-[β-D-吡喃葡萄糖基(1-3)-]-α-L-阿拉伯吡喃梨糖苷酸28-O-[α-L-鼠李糖基(1-2)]-β-D-吡喃葡萄糖苷。Latifolioside H(3) 是 3-O-[α-L-吡喃鼠李糖基(1-2)]-[β-D-吡喃葡萄糖基(1-3)-]-α-L-阿拉伯吡喃糖基siaresinolic acid 28-O-[alpha -L-吡喃鼠李糖基(1-2)]-β-D-吡喃葡萄糖苷。
• Ursane-type triterpene oligoglycosides with anti-hepatosteatosis and anti-hyperlipidemic activity from the leaves of Ilex paraguariensis A. St.-Hil.
  作者：Akifumi Nagatomo、Naoki Inoue、Takuya Konno、Yin Xu、Chinatsu Sakamoto、Mayuko Sone、Aya Shibasaka、Osamu Muraoka、Kiyofumi Ninomiya、Masayuki Yoshikawa、Yoshiaki Manse、Toshio Morikawa

  DOI：10.1007/s11418-022-01614-5

  日期：2022.6

  The methanol extract from the leaves of Ilex paraguariensis A. St.-Hil. (Aquifoliaceae), popularly known as mate, maté, or yerba maté, inhibits the intracellular triglyceride accumulation in HepG2 cells and suppresses the plasma triglyceride elevation in olive oil-treated mice. Three new triterpene saponins, termed mateosides I (1), II (2), and III (3), were isolated from the extract along with 29

  巴拉圭冬青A. St.- Hil叶子的甲醇提取物。（水飞蓟科），俗称马黛茶、马黛茶或马黛茶，可抑制 HepG2 细胞中的细胞内甘油三酯积累，并抑制橄榄油处理小鼠的血浆甘油三酯升高。从提取物中分离出三种新的三萜皂苷，称为马甙 I ( 1 )、II ( 2 ) 和 III ( 3 )，以及 29 种已知化合物。基于化学和光谱证据阐明了1 – 3的结构。在分离物中，主要皂苷成分2和 matesaponins 1 ( 7 ) 和 2 ( 9)，有效抑制同时用油酸和高葡萄糖处理的 HepG2 细胞中甘油三酯的积累。I. paraguariensis甲醇提取物的体内测定显示，7和9在橄榄油处理的小鼠中显示出抗高血脂活性。这些结果表明，I. paraguariensis的皂苷成分可能是抗肥胖活性的有价值的生物活性标志物。 图形概要
• Polynucleotide binding complexes comprising sterols and saponin
  申请人：Nordic Vaccine Technology A/S

  公开号：EP2011517A1

  公开（公告）日：2009-01-07

  The present invention pertains to complexes comprising sterols and saponins. The complexes are capable of binding a genetic determinant including a polynucleotide. The complexes may further comprise a lipophilic moiety, optionally a lipophilic moiety comprising a contacting group and/or a targeting ligand, and/or a saccharide moiety. The complexes may further comprise an immunogenic determinant and/or an antigenic determinant and/or a medicament and/or a diagnostic compound. The complexes may in even further embodiments be encapsulated by an encapsulation agent including a biodegradable microsphere. The present invention also pertains to pharmaceutical compositions and methods of treatment of an individual by therapy and/or surgery, methods of cosmetic treatment, and diagnostic methods practised on the human or animal body.

  本发明涉及由甾醇和皂甙组成的复合物。这些复合物能够结合包括多核苷酸在内的遗传决定因子。复合物可进一步包含亲脂分子，可选择包含接触基团和/或靶向配体的亲脂分子和/或糖分子。复合物可进一步包括免疫原决定簇和/或抗原决定簇和/或药物和/或诊断化合物。在更进一步的实施方案中，复合物可被包括生物可降解微球在内的封装剂封装。本发明还涉及通过治疗和/或手术对个体进行治疗的药物组合物和方法、美容治疗方法以及对人体或动物体进行诊断的方法。
• Triterpene Saponins from the Aerial Parts of Ilex cornuta and Their Cytotoxic Activity
  作者：Kang Ro Lee、Seung Young Lee、Won Se Suh、Ho Kyung Kim、Il Kyun Lee、Sang Un Choi、Ki Hyun Kim

  DOI：10.3987/com-15-13175

  日期：——

  Four new triterpene saponins (1-4), together with 13 known triterpenoids (5-17), were isolated from the MeOH extract of flex cornuta Lindley (Aquifoliaceae). Their structures were elucidated on the basis of chemical and spectroscopic methods. The isolated compounds were tested for their cytotoxicities against four human tumor cell lines. (A549, SK-OV-3, SK-MEL-2, and HCT15) in vitro using the sulforhodamine B (SRB) assay.