6-methyl-4-methyl-8-<(1-propyl-4-aminobutyl)amino>quinoline | 76367-84-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-methyl-4-methyl-8-<(1-propyl-4-aminobutyl)amino>quinoline
• 英文别名: 6-methyl-4-methyl-8-[(1-propyl-4-aminobutyl)amino]quinoline；4-N-(6-methoxy-4-methylquinolin-8-yl)heptane-1,4-diamine
• CAS: 76367-84-5
• 化学式: C₁₈H₂₇N₃O
• 分子量: 301.432
• InChiKey: IYFHIGWKTHNMBE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  60.2
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-methyl-4-methyl-8-<(1-propyl-4-aminobutyl)amino>quinoline 、 磷酸 生成 4-N-(6-methoxy-4-methylquinolin-8-yl)heptane-1,4-diamine;phosphoric acid
  参考文献：
  名称：

  YAN SHOU-JEN; CHIEN PING-LU; CHENG C. C., J. MED. CHEM.,1981, 24, NO 2, 215-217

  摘要：

  DOI：
• 作为产物：
  描述：

  1,4-dibromoheptane 在 二异丙胺 、 肼 作用下， 以 乙二醇乙醚 、 乙醇 、 丙酮 为溶剂， 反应 95.0h， 生成 6-methyl-4-methyl-8-<(1-propyl-4-aminobutyl)amino>quinoline
  参考文献：
  名称：

  Synthesis and antimalarial activity of 8-[(1-alkyl-4-aminobutyl)amino]-6-methoxy-4-methylquinolines

  摘要：

  Three analogues of the causal prophylactic antimalarial primaquine were prepared and their antimalarial activity was evaluated. 8-[(1-Ethyl-4-aminobutyl)amino]-6-methoxy-4-methylquinoline (2a) demonstrated activity against Plasmodium berghei in mice at 20 mg/kg, with all animals cured at 320 mg/kg, and is without toxicity at 640 mg/kg. It also possessed outstanding causal prophylactic activity against Plasmodium cynomolgi in rhesus monkeys at very low dosages.

  DOI：

  10.1021/jm00134a019

文献信息

• YAN SHOU-JEN; CHIEN PING-LU; CHENG C. C., J. MED. CHEM.,1981, 24, NO 2, 215-217
  作者：YAN SHOU-JEN、 CHIEN PING-LU、 CHENG C. C.

  DOI：——

  日期：——
• Synthesis and antimalarial activity of 8-[(1-alkyl-4-aminobutyl)amino]-6-methoxy-4-methylquinolines
  作者：Shou-Jen Yan、Ping-Lu Chien、C. C. Cheng

  DOI：10.1021/jm00134a019

  日期：1981.2

  Three analogues of the causal prophylactic antimalarial primaquine were prepared and their antimalarial activity was evaluated. 8-[(1-Ethyl-4-aminobutyl)amino]-6-methoxy-4-methylquinoline (2a) demonstrated activity against Plasmodium berghei in mice at 20 mg/kg, with all animals cured at 320 mg/kg, and is without toxicity at 640 mg/kg. It also possessed outstanding causal prophylactic activity against Plasmodium cynomolgi in rhesus monkeys at very low dosages.