diethyl-malonic acid bis-(4-amino-2-methyl-[6]quinolylamide)

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: diethyl-malonic acid bis-(4-amino-2-methyl-[6]quinolylamide)
• 英文别名: Diaethyl-malonsaeure-bis-(4-amino-2-methyl-[6]chinolylamid)；N,N'-bis(4-amino-2-methylquinolin-6-yl)-2,2-diethylpropanediamide
• 化学式: C₂₇H₃₀N₆O₂
• 分子量: 470.574
• InChiKey: JKILEGTUUFNTJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  35
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  136
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3-(4-乙酰氨基苯胺基)巴豆酸乙酯 在 二苯醚 、 联苯 、 溶剂黄146 、 甲苯 作用下， 生成 diethyl-malonic acid bis-(4-amino-2-methyl-[6]quinolylamide)
  参考文献：
  名称：

  制备4,6-二氨基喹哪啶的一些酰胺。

  摘要：

  DOI：

  10.1021/ja01192a031

文献信息

• COMPOSITIONS AND METHODS FOR BONE FORMATION AND MODELING
  申请人：ENZO Biochem, Inc.

  公开号：US20130172332A1

  公开（公告）日：2013-07-04

  The present disclosure is directed to methods of identifying a compound that binds to or interacts with a protein receptor involved in bone formation. Specifically, the disclosure is directed to methods of identifying a compound that regulates a Wnt pathway in a cell by binding to or interacting with cavities in proteins such as LRP5, LRP 6 and/or frizzled receptor and interfering with receptor binding to other proteins in a Wnt pathway. The present disclosure is further directed to methods and compositions that comprise an identified compound for treating or preventing a disease in a mammal in which Wnt pathway suppression plays a role.
• US8969339B2
  申请人：——

  公开号：US8969339B2

  公开（公告）日：2015-03-03
• The Preparation of Some Amides of 4,6-Diaminoquinaldine¹
  作者：Margaret G. Pratt、S. Archer

  DOI：10.1021/ja01192a031

  日期：1948.12