10-methyl-9-oxo-9,10-dihydroacridine-2,7-disulfonyl dichloride | 1083163-48-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 10-methyl-9-oxo-9,10-dihydroacridine-2,7-disulfonyl dichloride
• 英文别名: N-methyl-9(10H)-acridone-2,7-disulfonyl dichloride；10-methylacridin-9-one-2,7-disulfonyl chloride；10-methyl-9-oxoacridine-2,7-disulfonyl chloride
• CAS: 1083163-48-7
• 化学式: C₁₄H₉Cl₂NO₅S₂
• 分子量: 406.267
• InChiKey: YWPGQSODJDSJSN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  105
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  10-methyl-9-oxo-9,10-dihydroacridine-2,7-disulfonyl dichloride 在 劳森试剂 、 吡啶 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 14.0h， 生成 2,7-bis(3,5-dimethylpiperidin-1-ylsulfonyl)-9-(3-dimethylaminopropyl)imino-10-methyl-(9H,10H)-acridine
  参考文献：
  名称：

  JP5782586

  摘要：

  公开号：
• 作为产物：
  描述：

  甲基-蒽酮 在 氯磺酸 作用下， 以 paraffin oil 为溶剂， 反应 24.0h， 以30%的产率得到10-methyl-9-oxo-9,10-dihydroacridine-2,7-disulfonyl dichloride
  参考文献：
  名称：

  合成水溶性a啶酮的全面光谱，光物理和电化学研究。新型的pH和极性敏感荧光探针

  摘要：

  氮的光谱，光物理和电化学研究-烷基ac啶酮，它们新合成的氯磺酰基和水溶性磺酸衍生物已在室温下在溶液中进行。该研究包括吸收光谱和发射光谱，以及对第一个激发单重态的失活的定量测量，由此获得了所有衰减过程的速率常数。考虑了电子光谱和光物理性质的逐渐变化与取代度的比较。另外，通过循环和微分脉冲伏安法获得了在不同pH值下的水溶性a烯的电化学行为。发现二磺化a啶酮的氧化机理发生在一个连续且不可逆的电荷转移pH依赖性反应中。发现水溶性a啶酮显示出长寿命值，这取决于pH值和溶剂极性。这为用作不同细胞环境和靶标的选择性探针打开了一扇门。

  DOI：

  10.1016/j.dyepig.2019.03.028

文献信息

• NIR TO SWIR FLUORESCENT COMPOUNDS FOR IMAGING AND DETECTION
  申请人：PERKINELMER HEALTH SCIENCES, INC.

  公开号：US20190100654A1

  公开（公告）日：2019-04-04

  This disclosure provides a family of compounds that absorb and fluoresce in the short wave infrared region (SWIR, optionally 1000 nm to 1300 nm), including hydrophilic compounds that exhibit absorption and emission spectral profiles in aqueous solutions substantially similar to those observed in organic solvents such as methanol or DMSO. The compounds can be chemically linked to biomolecules including proteins, nucleic acids, and therapeutic small molecules. The compounds are useful for imaging in a variety of medical, biological and diagnostic applications, including SWIR in vivo imaging of regions of interest within a mammal.

  这份披露提供了一类在短波红外区域（SWIR，可选1000纳米至1300纳米）吸收和发射光的化合物家族，包括在水溶液中表现出吸收和发射光谱特性与甲醇或DMSO等有机溶剂中观察到的基本相似的亲水性化合物。这些化合物可以与蛋白质、核酸和治疗性小分子等生物分子化学连接。这些化合物可用于在各种医学、生物学和诊断应用中进行成像，包括对哺乳动物体内感兴趣区域进行SWIR成像。
• [EN] DERIVATIVES OF MULTI-RING AROMATIC COMPOUNDS AND USES AS ANTI-TUMOR AGENTS<br/>[FR] DÉRIVÉS DE COMPOSÉS AROMATIQUES À NOYAUX MULTIPLES ET UTILISATIONS COMME AGENTS ANTI-TUMORAUX
  申请人：AVALON PHARMACEUTICALS

  公开号：WO2010082912A1

  公开（公告）日：2010-07-22

  Chemical agents, such as disulfonamide derivatives of fluorene, anthracene, xanthene, dibenzosuberone and acridine, and similar heterocyclic ring structures, including salts thereof, that act as anti-cancer and anti-tumor agents, are disclosed, along with methods for preparing such agents, as well as pharmaceutical compositions containing such agents as active ingredients and methods of using these as therapeutic agents.

  本文披露了化学试剂，如萘、蒽、联苯并呋喃、二苯并吡喃和吖啶的二磺酰胺衍生物等，以及类似的杂环环结构，包括其盐，作为抗癌和抗肿瘤试剂，并披露了制备这些试剂的方法，以及含有这些试剂作为活性成分的药物组合物，以及使用这些试剂作为治疗试剂的方法。
• DERIVATIVES OF FLUORENE, ANTHRACENE, XANTHENE, DIBENZOSUBERONE AND ACRIDINE AND USES THEREOF
  申请人：Cholody Wieslaw M.

  公开号：US20100137354A1

  公开（公告）日：2010-06-03

  Chemical agents, such as disulfonamide derivatives of fluorene, anthracene, xanthene, dibenzosuberone and acridine, and similar heterocyclic ring structures, including salts thereof, that act as anti-cancer and anti-tumor agents, especially where such agents modulate the activity of the Wnt/β-catenin signaling pathway, and serve to reduce β-catenin levels present in cells, such as cancer cells, or where the agents modulate levels of gene expression in cellular systems, including cancer cells, are disclosed, along with methods for preparing such agents, as well as pharmaceutical compositions containing such agents as active ingredients and methods of using these as therapeutic agents.

  本发明涉及化学剂，例如荧光烯，蒽，三苯甲烷和吖啶的二磺酰胺衍生物，以及类似的杂环环结构及其盐，这些化学剂作为抗癌和抗肿瘤剂，特别是当这些剂调节Wnt/β-连环蛋白信号通路的活性时，并能降低β-连环蛋白在细胞中（如癌细胞）的水平，或当这些剂调节细胞系统（包括癌细胞）的基因表达水平时。此外，本发明还揭示了制备这些化学剂的方法，以及包含这些化学剂作为活性成分的制药组合物和使用它们作为治疗剂的方法。
• Derivatives of fluorene, anthracene, xanthene, dibenzosuberone and acridine and uses thereof
  申请人：——

  公开号：US08129519B2

  公开（公告）日：2012-03-06

  Chemical agents, such as disulfonamide derivatives of fluorene, anthracene, xanthene, dibenzosuberone and acridine, and similar heterocyclic ring structures, including salts thereof, that act as anti-cancer and anti-tumor agents, especially where such agents modulate the activity of the Wnt/β-catenin signaling pathway, and serve to reduce β-catenin levels present in cells, such as cancer cells, or where the agents modulate levels of gene expression in cellular systems, including cancer cells, are disclosed, along with methods for preparing such agents, as well as pharmaceutical compositions containing such agents as active ingredients and methods of using these as therapeutic agents.

  本发明公开了一种化学剂，其为萤光烯、蒽、黄色素、二苯并[2,3-b:3',2'-e]苯酮和吖啶的二磺酰胺衍生物，以及类似的杂环环结构和其盐，可作为抗癌和抗肿瘤药物，特别是这些药物可以调节Wnt/β-连环蛋白信号通路的活性，并降低细胞中（如癌细胞）存在的β-连环蛋白水平，或者这些药物可以调节细胞系统（包括癌细胞）中的基因表达水平。本发明还公开了制备这些化学剂的方法，以及包含这些化学剂作为活性成分的制药组合物和使用这些组合物作为治疗剂的方法。
• Derivatives of Fluorene, Anthracene, Xanthene, Dibenzosuberone and Acridine and Uses Thereof
  申请人：Cholody Wieslaw M.

  公开号：US20120129837A1

  公开（公告）日：2012-05-24

  Chemical agents, such as disulfonamide derivatives of fluorene, anthracene, xanthene, dibenzosuberone and acridine, and similar heterocyclic ring structures, including salts thereof, that act as anti-cancer and anti-tumor agents, especially where such agents modulate the activity of the Wnt/β-catenin signaling pathway, and serve to reduce β-catenin levels present in cells, such as cancer cells, or where the agents modulate levels of gene expression in cellular systems, including cancer cells, are disclosed, along with methods for preparing such agents, as well as pharmaceutical compositions containing such agents as active ingredients and methods of using these as therapeutic agents.

  本发明涉及一种化学试剂，例如芴，蒽，黄色素，二苯基甲酮和吖啶的二磺酰胺衍生物，以及类似的杂环环结构，包括其盐，作为抗癌和抗肿瘤试剂，特别是这些试剂能够调节Wnt/β-连环蛋白信号通路的活性，降低细胞中（如癌细胞）的β-连环蛋白水平，或者这些试剂调节细胞系统（包括癌细胞）中基因表达水平。同时，本发明还涉及制备这些试剂的方法，以及包含这些试剂作为活性成分的制药组合物和使用这些组合物作为治疗试剂的方法。