【草(之上)+皆】酮 | 497-62-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 【草(之上)+皆】酮
• 英文名称: caran-2-one
• 英文别名: 3,7,7-trimethyl, bicyclo[4.1.0] heptane-2-one；Isocaranon；3,7,7-Trimethylbicyclo<4.1.0>heptan-2-on；3,7,7-trimethylbicyclo[4.1.0]heptan-2-one
• CAS: 497-62-1
• 化学式: C₁₀H₁₆O
• 分子量: 152.236
• InChiKey: CNJLMVZFWLNOEP-UHFFFAOYSA-N

物化性质

• 保留指数：
  1252;1252

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  【草(之上)+皆】酮 在 硫酸 作用下， 生成 3-异丙基-6-甲基-2-环己烯-1-酮
  参考文献：
  名称：

  Rimini, Gazzetta Chimica Italiana, 1909, vol. 39 II, p. 203

  摘要：

  DOI：
• 作为产物：
  描述：

  8-bromo-p-menthan-2-one 在 乙醚 、 potassium carbonate 作用下， 生成 【草(之上)+皆】酮
  参考文献：
  名称：

  Baeyer, Chemische Berichte, 1894, vol. 27, p. 1920,1923

  摘要：

  DOI：

文献信息

• [EN] COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING IMIDAZOLE AND TRIAZOLE DERIVATIVES<br/>[FR] COMPOSÉS, COMPOSITIONS ET PROCÉDÉS COMPRENANT DES DÉRIVÉS D'IMIDAZOLE ET DE TRIAZOLE
  申请人：INST ONEWORLD HEALTH

  公开号：WO2010033626A1

  公开（公告）日：2010-03-25

  The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-3 or encompassed by formulas (I), (IA), (IB), (II), and (III)) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.

  本发明涉及用于治疗动物疾病的组合物和方法，该疾病对通过向需要的哺乳动物投与本文中定义的化合物的有效量（包括表1-3中列出的那些化合物或由公式（I）、（IA）、（IB）、（II）和（III）所包含的化合物）或其组合物来抑制功能性囊性纤维化跨膜传导调节蛋白（CFTR）多肽作出反应，从而治疗该疾病。本发明特别涉及一种治疗腹泻和多囊肾病的方法。
• Compounds, Compositions and Methods Comprising Pyrazole Derivatives
  申请人：Penrose Stephen David

  公开号：US20100267741A1

  公开（公告）日：2010-10-21

  The present invention relates to compounds, compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-2 or encompassed by formulas Ia, Ib, IIa, and IIb) or compositions comprising these compounds, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.

  本发明涉及化合物、组合物和治疗动物疾病的方法，该疾病对通过给予需要的哺乳动物本文所定义的化合物的有效量（包括表1-2中列出的那些化合物或被公式Ia、Ib、IIa和IIb所包含的化合物）或包含这些化合物的组合物来抑制功能性囊性纤维化跨膜传导调节蛋白（CFTR）多肽作出反应，从而治疗该疾病。本发明特别涉及一种治疗腹泻和多囊肾病的方法。
• Compounds, Compositions and Methods Comprising Isoxazole Derivatives
  申请人：Jones Graham Peter

  公开号：US20090264486A1

  公开（公告）日：2009-10-22

  The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-2 or encompassed by formulas I-II) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.

  本发明涉及用于治疗动物患病的组合物和方法，该疾病对通过向需要的哺乳动物投与本文所定义的化合物的有效量（包括表1-2中列出的那些化合物或由I-II式包围的化合物）或其组合物来抑制功能性囊性纤维化跨膜传导调节蛋白（CFTR）多肽作出反应，从而治疗该疾病。本发明特别涉及一种治疗腹泻和多囊肾病的方法。
• [EN] COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING PYRIDAZINE SULFONAMIDE DERIVATIVES<br/>[FR] COMPOSÉS, COMPOSITIONS ET MÉTHODES COMPRENANT DES DÉRIVÉS DE PYRIDAZINE SULFONAMIDE
  申请人：INST ONEWORLD HEALTH

  公开号：WO2010123822A1

  公开（公告）日：2010-10-28

  The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-3 or encompassed by formula I-III) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.

  本发明涉及用于治疗动物的疾病的组合物和方法，所述疾病对通过向需要它的哺乳动物施用本发明定义的有效量的化合物（包括表1-3中列出的或由公式I-III涵盖的化合物）或其组合物从而抑制功能性囊性纤维化跨膜电导调节器（CFTR）多肽的治疗有响应。特别是，本发明涉及治疗腹泻和多囊肾疾病的方法。
• [EN] PHOSPHATE PRODRUGS<br/>[FR] PROMÉDICAMENTS DU PHOSPHATE
  申请人：INST ONEWORLD HEALTH

  公开号：WO2013019169A1

  公开（公告）日：2013-02-07

  Phosphate and phosphonate prodrug derivatives, for example of Formula IV; where p, A, LA, and R1, R3-R6 are as defined herein, are useful for treating various disorders, including diarrhea.

  磷酸盐和膦酸盐前药衍生物，例如公式IV的；其中p，A，LA，以及R1，R3-R6按本文定义，可用于治疗包括腹泻在内的各种疾病。