2-methyl-6,7-difluoro-8-hydroxyquinoline | 1432043-25-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-methyl-6,7-difluoro-8-hydroxyquinoline
• 英文别名: 2-Methyl-6,7-difluoro-8-hydroxyquinoline；6,7-difluoro-2-methylquinolin-8-ol
• CAS: 1432043-25-8
• 化学式: C₁₀H₇F₂NO
• 分子量: 195.168
• InChiKey: LMEXVGQSESJYJK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  33.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-methyl-6,7-difluoro-8-hydroxyquinoline 在 盐酸 作用下， 以 乙醇 、 水 为溶剂， 反应 24.0h， 生成 (E)-2-[2-(4-methoxyphenyl)vinyl]-6,7-difluoro-8-hydroxyquinoline
  参考文献：
  名称：

  Synthesis and fluorescent properties of 2-styryl-6,7-difluoro-8-hydroxyquinoline and its Zn(II) complex

  摘要：

  A synthetic approach to 2-methyl-6,7-difluoro-8-hydroxyquinoline, a key intermediate, has been developed. 6,7-Difluoro derivative of 2-styryl substituted 8-hydroxyquinoline and its Zn(II) complex have been obtained. Effects of fluorine atoms in the benzene ring on photophysical properties of 2-styryl-8-hydroxyquinolines and their Zn(II) complexes have been studied. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2013.03.005
• 作为产物：
  描述：

  6-氨基-2,3-二氟苯酚 、 丁烯-2-醛 在 盐酸 作用下， 以 水 为溶剂， 反应 16.0h， 以51%的产率得到2-methyl-6,7-difluoro-8-hydroxyquinoline
  参考文献：
  名称：

  Synthesis and fluorescent properties of 2-styryl-6,7-difluoro-8-hydroxyquinoline and its Zn(II) complex

  摘要：

  A synthetic approach to 2-methyl-6,7-difluoro-8-hydroxyquinoline, a key intermediate, has been developed. 6,7-Difluoro derivative of 2-styryl substituted 8-hydroxyquinoline and its Zn(II) complex have been obtained. Effects of fluorine atoms in the benzene ring on photophysical properties of 2-styryl-8-hydroxyquinolines and their Zn(II) complexes have been studied. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2013.03.005

文献信息

• Synthesis, structure and photoluminescent properties of BF2 and BPh2 complexes with N,O-benzazine ligands
  作者：Emiliya V. Nosova、Tatyana N. Moshkina、Galina N. Lipunova、Inna V. Baklanova、Pavel A. Slepukhin、Valery N. Charushin

  DOI：10.1016/j.jfluchem.2015.04.010

  日期：2015.7

  Novel N,O-bidentate BF2 and BPh2 complexes have been prepared in good to excellent yields through coordination of 8-hydroxy-2-methylquinolines and 2-(2-hydroxyphenyl)-3H-quinazolin-4-ones with boron trifluoride etherate or triphenylborane under mild conditions. All complexes have been characterized by H-1, B-11 and F-19 NMR, mass-spectrometry and X-ray crystallography data. Some complexes have been found to exhibit a significant fluore.scence in acetonitrile solutions. Electronic and site effects of substituents in both heterocyclic and phenol fragments proved to have a profound impact on quantum yields. (C) 2015 Elsevier B.V. All rights reserved.
• Synthesis and fluorescent properties of 2-styryl-6,7-difluoro-8-hydroxyquinoline and its Zn(II) complex
  作者：Emiliya V. Nosova、Tatyana V. Stupina、Galina N. Lipunova、Valery N. Charushin

  DOI：10.1016/j.jfluchem.2013.03.005

  日期：2013.6

  A synthetic approach to 2-methyl-6,7-difluoro-8-hydroxyquinoline, a key intermediate, has been developed. 6,7-Difluoro derivative of 2-styryl substituted 8-hydroxyquinoline and its Zn(II) complex have been obtained. Effects of fluorine atoms in the benzene ring on photophysical properties of 2-styryl-8-hydroxyquinolines and their Zn(II) complexes have been studied. (C) 2013 Elsevier B.V. All rights reserved.