3,3-dimethyl-2,2-dichloro-1-hydroxymethyl-cyclopropane | 52815-11-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3,3-dimethyl-2,2-dichloro-1-hydroxymethyl-cyclopropane
• 英文别名: (2,2-dichloro-3,3-dimethylcyclopropyl)methanol；(2,2-dimethyl-3,3-dichlorocyclopropyl)methanol；2,2-dichloro-3,3-dimethylcyclopropylmethanol；2,2-dichloro-3,3-dimethylcyclopropanemethanol
• CAS: 52815-11-9
• 化学式: C₆H₁₀Cl₂O
• 分子量: 169.051
• InChiKey: HYOFFFZOXWCQII-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3,3-dimethyl-2,2-dichloro-1-hydroxymethyl-cyclopropane 在 potassium permanganate 作用下， 反应 2.0h， 以67%的产率得到2,2-二氯-3,3-二甲基环丙烷-1-羧酸
  参考文献：
  名称：

  A new pathway for the synthesis of 2,2-dimethyl-3,3-dichlorocyclopropanecarboxylic acid

  摘要：

  DOI：

  10.1007/bf00955858
• 作为产物：
  描述：

  梨醇酯 在 sodium hydroxide 、 苄基三乙基氯化铵 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 2.17h， 生成 3,3-dimethyl-2,2-dichloro-1-hydroxymethyl-cyclopropane
  参考文献：
  名称：

  A new pathway for the synthesis of 2,2-dimethyl-3,3-dichlorocyclopropanecarboxylic acid

  摘要：

  DOI：

  10.1007/bf00955858

文献信息

• [EN] PYRROLIDINE DERIVATIVES AND THEIR USE AS COMPLEMENT PATHWAY MODULATORS<br/>[FR] DÉRIVÉS PYRROLIDINE ET LEUR UTILISATION EN TANT QUE MODULATEURS DE LA VOIE DU COMPLÉMENT
  申请人：NOVARTIS AG

  公开号：WO2014002054A1

  公开（公告）日：2014-01-03

  The present invention provides a compound of formula (I) a method for manufacturing the compounds of the invention, and its therapeutic uses as complement pathway modulators for the treatment of ocular diseases. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

  本发明提供了一种化合物(I)的方法，用于制造该发明的化合物，并将其用作眼部疾病治疗的补体途径调节剂。本发明还提供了一种药理活性剂的组合和制药组合物。
• [EN] METAL ORGANIC COMPOUNDS<br/>[FR] COMPOSÉS ORGANOMÉTALLIQUES
  申请人：UMICORE AG & CO KG

  公开号：WO2021197597A1

  公开（公告）日：2021-10-07

  The invention concerns a process for preparing an essentially silicon (Si) free compounds of the general formula [M(O)(OR)y], wherein M = Mo, y = 3 or M = W, y = 3 or 4. Furthermore, it is directed towards compounds obtained by the aforementioned process and towards the use of such an obtained compound. Another objective of the herein described invention are essentially silicon free compounds of the general formula MOXy or [MOXy(solv)p], prepared using the aforementioned process, wherein M = Mo, y = 3 or M = W, y = 3 or 4, X = Cl or Br, solv = an oxidizing agent Z binding or coordinating to M via at least one donor atom, p = 1 or 2. The invention is also directed towards the use of essentially silicon free compounds prepared using the aforementioned process of the general formula MOXy or [MOXy(solv)p].

  该发明涉及一种制备通式[M(O)(OR)y]的基本无硅（Si）化合物的过程，其中M = Mo，y = 3或M = W，y = 3或4。此外，它针对通过上述过程获得的化合物以及利用这种获得的化合物的用途。所述发明的另一个目标是使用上述过程制备的通式MOXy或[MOXy(solv)p]的基本无硅化合物，其中M = Mo，y = 3或M = W，y = 3或4，X = Cl或Br，solv = 通过至少一个供体原子与M结合或配位的氧化剂Z，p = 1或2。该发明还涉及利用利用上述通式MOXy或[MOXy(solv)p]的基本无硅化合物的方法。
• Cyclopentenone Synthesis from 1,1-Dichloroallyllithium–Ketone Adducts as Well as from Dichlorocarbene–Allyl Alcohol Adducts
  作者：Tamejiro Hiyama、Masaki Shinoda、Masao Tsukanaka、Hitosi Nozaki

  DOI：10.1246/bcsj.53.1010

  日期：1980.4

  Treatment of (3,3-dialkyl-2,2-dichlorocyclopropyl)methanols with hydrobromic acid gives 2-cyclopentenones through postulated intermediates, 3-chlorocyclopentadienyl cations. Another method which sh...

  用氢溴酸处理（3,3-二烷基-2,2-二氯环丙基）甲醇，通过假定的中间体 3-氯环戊二烯基阳离子得到 2-环戊烯酮。另一种方法...
• [EN] PYRIMIDINE COMPOUNDS AND THEIR USE AS PESTICIDES<br/>[FR] COMPOSÉS DE PYRIMIDINE ET LEUR UTILISATION EN TANT QUE PESTICIDES
  申请人：SUMITOMO CHEMICAL CO

  公开号：WO2012050237A1

  公开（公告）日：2012-04-19

  Pyrimidine compound of Formula (1): (1) wherein R1 is C1-C3 chain hydrocarbon group optionally substituted with one or more halogens, etc.; R2 is C1-C3 chain hydrocarbon group optionally substituted with one or more halogens, etc.; G1 is nitrogen or -CR5=, etc.; R3 is C1-C3 chain hydrocarbon group optionally substituted with one or more halogens, etc.; R4 is C1-C6 chain hydrocarbon group optionally substituted with one or more halogens, etc.; Q is oxygen, etc., Cyc is C3-C8 cycloalkyl group, etc.; and A is single bond, etc. having excellent pest control activity.

  式（1）中的嘧啶化合物：（1）其中R1是C1-C3链烃基，可选择地取代一个或多个卤素等；R2是C1-C3链烃基，可选择地取代一个或多个卤素等；G1是氮或-CR5=等；R3是C1-C3链烃基，可选择地取代一个或多个卤素等；R4是C1-C6链烃基，可选择地取代一个或多个卤素等；Q是氧等，Cyc是C3-C8环烷基等；A是单键等，具有优异的杀虫活性。
• 2,2-Dihalogeno-3,3-dimethylcyclopropane derivative fungicides
  申请人：Nihon Tokushu Noyaku Seizo K.K.

  公开号：US04514418A1

  公开（公告）日：1985-04-30

  A 2,2-dihalogeno-3,3-dimethylcyclopropylmethyl derivative of the formula ##STR1## in which X and Y each independently is halogen, R is a hydrogen atom or a methyl group, Z is a cyano group, a thiocyano group, a group of the formula ##STR2## or a group of the formula ##STR3## Hal is a halogen atom, n is 0 or 1, and Q is a lower alkyl group, a halo-lower alkyl group, a phenyl group, or a phenyl group substituted by at least one of halogen, lower alkyl and nitro, which is an intermediate in further syntheses to produce biologically active substances such as insecticides and which is itself fungicidally active.

  该化合物为2,2-二卤代-3,3-二甲基环丙基甲基衍生物，化学式为##STR1## 其中，X和Y各自独立地为卤素，R为氢原子或甲基基团，Z为氰基、硫氰基、式##STR2## 的基团或式##STR3## 的基团，Hal为卤素原子，n为0或1，Q为低碳基、卤代低碳基、苯基或至少一个卤素、低碳基或硝基取代的苯基，该化合物是生物活性物质的进一步合成的中间体，例如杀虫剂，并且本身具有杀菌活性。