3-乙酰基-4-羟基-2-苯基喹啉 | 101600-64-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 3-乙酰基-4-羟基-2-苯基喹啉
• 英文名称: 3-acetyl-4-hydroxy-2-phenylquinoline
• 英文别名: 1-(4-hydroxy-2-phenyl-[3]quinolyl)-ethanone；1-(4-Hydroxy-2-phenyl-[3]chinolyl)-aethanon；Ethanone, 1-(4-hydroxy-2-phenyl-3-quinolinyl)-；3-acetyl-2-phenyl-1H-quinolin-4-one
• CAS: 101600-64-0
• 化学式: C₁₇H₁₃NO₂
• 分子量: 263.296
• InChiKey: JFRVNPXEGYNJDY-UHFFFAOYSA-N

物化性质

• 熔点：
  282-284 °C(Solv: acetic acid (64-19-7))
• 沸点：
  457.3±45.0 °C(Predicted)
• 密度：
  1.241±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-乙酰基-4-羟基-2-苯基喹啉 在 selenium(IV) oxide 、 乙醇 作用下， 生成 (4-hydroxy-2-phenyl-[3]quinolyl)-glyoxal
  参考文献：
  名称：

  Structures of the Products Obtained by the Condensation of Phenylbenzimino Chloride and Ethyl Sodioacetoacetate and Subsequent Cyclization¹

  摘要：

  DOI：

  10.1021/ja01604a042
• 作为产物：
  描述：

  N-苯基亚胺苄基氯 在 二苯醚 作用下， 生成 3-乙酰基-4-羟基-2-苯基喹啉
  参考文献：
  名称：

  Structures of the Products Obtained by the Condensation of Phenylbenzimino Chloride and Ethyl Sodioacetoacetate and Subsequent Cyclization¹

  摘要：

  DOI：

  10.1021/ja01604a042

文献信息

• Regioselective Condensation of Alkylidenephosphoranes with Bifunctionalized Compounds: New Approach to the Synthesis of Fused<i>O</i>- and<i>N</i>-Heterocycles
  作者：Wafaa M. Abdou、Neven A. F. Ganoub、Amin F. M. Fahmy、Abeer A. M. Shaddy

  DOI：10.1080/104265090921092

  日期：2005.10

  A series of fused pyran- (similar to 40% yield) and furan- (similar to 20% yield) derivatives were regioselectively prepared from the reactions of 5,6-difur-2'y1-3-oxo-2,3-dihydropyridazin-4-carbonitrile with ester- and keto phosphorus ylides, whereas new ylides were obtained, in addition to fused furans, in almost equal yields (33%) from the reaction of the same substrate with cyanomethylene(triphenyl)phosphorane. However application of such Wittig reagents on 2[(benzylidene)amino]-benzonitrile afforded, in all cases, 4-hydroxyquinalines in a similar to 42% yield as major products. Moreover; 2-[(triphenylphosphoranylidene)amino] benzonitrile, with the corresponding alkene, was also isolated a side products.
• Sinsky, M. S.; Bass, R. G., Journal of Heterocyclic Chemistry, 1984, vol. 21, p. 759 - 768
  作者：Sinsky, M. S.、Bass, R. G.

  DOI：——

  日期：——
• A New Synthesis of 2-Aryl-3-acetyl-4-hydroxyquinolines Using Polyphosphoric Acid
  作者：B. STASKUN

  DOI：10.1021/jo01066a040

  日期：1961.8
• SINSKY, M. S.;BASS, R. G., J. HETEROCYCL. CHEM., 1984, 21, N 3, 759-768
  作者：SINSKY, M. S.、BASS, R. G.

  DOI：——

  日期：——