4-二苄氨基-2-甲基苯甲醛 | 1424-65-3

• 物质功能分类: 医药中间体 - OLED材料中间体
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-二苄氨基-2-甲基苯甲醛
• 英文名称: 2-methyl-4-dibenzylaminobenzaldehyde
• 英文别名: 4-Dibenzylamino-2-methyl-benzaldehyd；4-(Dibenzylamino)-2-methylbenzaldehyde
• CAS: 1424-65-3
• 化学式: C₂₂H₂₁NO
• 分子量: 315.415
• InChiKey: JMVDVHYMDWJOSI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2922399090

反应信息

• 作为反应物：
  描述：

  4-二苄氨基-2-甲基苯甲醛 在 palladium on activated charcoal 乙酸铵 、 盐酸 、 lithium aluminium tetrahydride 、 氢气 、 溴 、 溶剂黄146 作用下， 以 四氢呋喃 、 乙醚 、 乙醇 为溶剂， 反应 8.0h， 生成 4-amino-5-bromo-2,α-dimethylphenethylamine
  参考文献：
  名称：

  Selective monoamine oxidase inhibitors. 4. 4-Aminophenethylamine derivatives with neuron-selective action

  摘要：

  Nine 4-aminophenethylamine derivatives were synthesized and tested for monoamine oxidase (MAO) inhibitory effects with particular attention to their selectivity for MAO within monoaminergic neurons in the rat brain. All compounds selectively inhibited the A form of MAO in vitro. Some of the compounds inhibited the MAO within the monoaminergic neurons at much lower doses than those required for inhibition of MAO within other cells in vivo. The most potent compounds in this respect were 4-amino-2-fluoro-alpha-methylphenethylamine (5) and 4-amino-2-chloro-alpha-methylphenethylamine (4).

  DOI：

  10.1021/jm00161a020
• 作为产物：
  描述：

  3-甲基苯胺 在 potassium carbonate 、 potassium iodide 、 三氯氧磷 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 生成 4-二苄氨基-2-甲基苯甲醛
  参考文献：
  名称：

  Selective monoamine oxidase inhibitors. 4. 4-Aminophenethylamine derivatives with neuron-selective action

  摘要：

  Nine 4-aminophenethylamine derivatives were synthesized and tested for monoamine oxidase (MAO) inhibitory effects with particular attention to their selectivity for MAO within monoaminergic neurons in the rat brain. All compounds selectively inhibited the A form of MAO in vitro. Some of the compounds inhibited the MAO within the monoaminergic neurons at much lower doses than those required for inhibition of MAO within other cells in vivo. The most potent compounds in this respect were 4-amino-2-fluoro-alpha-methylphenethylamine (5) and 4-amino-2-chloro-alpha-methylphenethylamine (4).

  DOI：

  10.1021/jm00161a020

文献信息

• Process for Producing Hydrazone Compound
  申请人：Takaso Kiyokazu

  公开号：US20080015387A1

  公开（公告）日：2008-01-17

  The present invention provides a process for producing a hydrazone compound represented by the general formula (5): which comprises a step of condensing a hydrazine compound represented by the general formula (3): with a carbonyl compound represented by the general formula (4): without taking the hydrazine compound out of a reactor According to the invention, the target hydrazone compound can be obtained in high quality and in a high yield without taking the hydrazine compound out of the reactor at all, the hydrazine compound being a reaction intermediate which is structurally unstable and has a fear of influencing safety of workers owing to its toxicity (mutagenicity).

  本发明提供了一种生产由通式（5）表示的腙化合物的过程，包括将通式（3）表示的腙化合物与通式（4）表示的羰基化合物缩合的步骤，而不需要将腙化合物从反应釜中取出。根据本发明，目标腙化合物可以在高质量和高产率的情况下获得，而无需将腙化合物从反应釜中取出，腙化合物是一种结构不稳定且具有毒性（致突变性）的反应中间体，可能会影响工人的安全。
• PROCESS FOR PRODUCING HYDRAZONE COMPOUND
  申请人：Hodogaya Chemical Co., Ltd.

  公开号：EP1762564B1

  公开（公告）日：2013-12-25
• UEDA, HIDEAKI
  作者：UEDA, HIDEAKI

  DOI：——

  日期：——
• ——
  作者：XAGIVARA TOSIMITSU、 TSURUDA XARUKI

  DOI：——

  日期：——
• FLORVALL L.; FAGERVALL I.; ASK A. -L.; ROSS S. B., J. MED. CHEM., 29,(1986) N 11, 2250-2256
  作者：FLORVALL L.、 FAGERVALL I.、 ASK A. -L.、 ROSS S. B.

  DOI：——

  日期：——