1-(2-methylimidazol-1-yl)sulfonyl-3,4-dihydro-2H-quinoline | 868623-12-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-(2-methylimidazol-1-yl)sulfonyl-3,4-dihydro-2H-quinoline
• CAS: 868623-12-5
• 化学式: C₁₃H₁₅N₃O₂S
• 分子量: 277.347
• InChiKey: MGNYWQOITKGAAZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  63.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(2-methylimidazol-1-yl)sulfonyl-3,4-dihydro-2H-quinoline 以 二氯甲烷 、 乙腈 为溶剂， 反应 2.0h， 生成 ethyl 2-[3,4-dihydro-2H-quinolin-1-ylsulfonyl-[[3-[[4-(trifluoromethyl)phenyl]methoxy]phenyl]methyl]amino]acetate
  参考文献：
  名称：

  Efficient synthesis of arylsulfamides by reaction of amines with arylsulfamoyl imidazolium triflate

  摘要：

  Aryisulfamoyl imidazolium triflates, readily prepared from the corresponding chlorides, react with amines under neutral conditions to form arylsulfamides in high yields. This methodology, which contrasts with the slow and inefficient reactions of amines with arylsulfamoyl chlorides, is applied to the synthesis of arylsulfamide 3a, a bioisotere of muraglitazar. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.08.092
• 作为产物：
  描述：

  1,2,3,4-tetrahydroquinoline-1-sulfonyl chloride 、 2-甲基咪唑 以 乙腈 为溶剂， 以90%的产率得到1-(2-methylimidazol-1-yl)sulfonyl-3,4-dihydro-2H-quinoline
  参考文献：
  名称：

  Efficient synthesis of arylsulfamides by reaction of amines with arylsulfamoyl imidazolium triflate

  摘要：

  Aryisulfamoyl imidazolium triflates, readily prepared from the corresponding chlorides, react with amines under neutral conditions to form arylsulfamides in high yields. This methodology, which contrasts with the slow and inefficient reactions of amines with arylsulfamoyl chlorides, is applied to the synthesis of arylsulfamide 3a, a bioisotere of muraglitazar. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.08.092

文献信息

• Efficient synthesis of arylsulfamides by reaction of amines with arylsulfamoyl imidazolium triflate
  作者：Hyeon Kyu Lee、Miyeon Bang、Chwang Siek Pak

  DOI：10.1016/j.tetlet.2005.08.092

  日期：2005.10

  Aryisulfamoyl imidazolium triflates, readily prepared from the corresponding chlorides, react with amines under neutral conditions to form arylsulfamides in high yields. This methodology, which contrasts with the slow and inefficient reactions of amines with arylsulfamoyl chlorides, is applied to the synthesis of arylsulfamide 3a, a bioisotere of muraglitazar. (c) 2005 Elsevier Ltd. All rights reserved.