2,2,8,8-tetramethyl-nonane-3,7-dione | 66922-16-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,2,8,8-tetramethyl-nonane-3,7-dione
• 英文别名: 2,2,8,8-Tetramethylnonane-3,7-dione
• CAS: 66922-16-5
• 化学式: C₁₃H₂₄O₂
• 分子量: 212.332
• InChiKey: QQIOLVCKLIMFGN-UHFFFAOYSA-N

物化性质

• 熔点：
  32.5-33.5 °C
• 沸点：
  127 °C(Press: 4 Torr)
• 密度：
  0.894±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,2,8,8-tetramethyl-nonane-3,7-dione 在 吡啶 、 TiCl₃-1,2-dimethoxyethane 、 铜 、 间氯过氧苯甲酸 、 锌 、 三氯氧磷 作用下， 以 乙二醇二甲醚 、 二氯甲烷 为溶剂， 反应 94.17h， 生成 1,2-di-tert-butylcyclopentadiene
  参考文献：
  名称：

  A New Synthesis of 1,5-Di-tert-butyl-1,3-cyclopentadiene by Dehydration of an Epoxide and Characterization of its Diels−Alder Dimer

  摘要：

  DOI：

  10.1021/jo9515586
• 作为产物：
  描述：

  2,6-二叔丁基吡啶 生成 2,2,8,8-tetramethyl-nonane-3,7-dione
  参考文献：
  名称：

  New nitrogen bases with severe steric hindrance due to flanking tert-butyl groups. cis-2,6-Di-tert-butylpiperidine. Possible steric blocking of olfaction

  摘要：

  DOI：

  10.1021/jo00413a003

文献信息

• One-methylene incorporated dimerization reaction of ketone enolates. 1. A new route to 1,5-diketones from ketones having α-active hydrogen on one side
  作者：Syun-ichi Kiyooka、Tsuneo Yamashita、Jun-ichi Tashiro、Kazuyuki Takano、Yasuto Uchio

  DOI：10.1016/s0040-4039(00)85285-5

  日期：——

  A novel reaction of ketone enolate with dimethylformamide (DMF) to give 1,5-diketone has been found. It is a dimerization of ketone enolates accompanying the incorporation of one-methyl one from DMF.

  已发现酮烯醇化物与二甲基甲酰胺（DMF）产生1，5-二酮的新反应。它是酮烯酸酯的二聚化，伴随有来自DMF的一甲基甲酸酯的引入。
• Enaminone Intermediate in the One-Methylene Incorporated Dimerization Reaction of Ketone Enolate. Cross Reaction to Unsymmetrical 1,5-Diketones
  作者：Syun-ichi Kiyooka、Tsuneo Yamashita

  DOI：10.1246/cl.1987.1775

  日期：1987.9.5

  An enaminone has been isolated as an intermediate from the one-methylene incorporated dimerization reaction of ketone enolate using N-phenyl-N-methylformamide. The reaction of the enaminone with the other ketone enolates gives unsymmetrical 1,5-diketones in good yields.

  已经从酮烯醇化物使用 N-苯基-N-甲基甲酰胺的一亚甲基结合的二聚反应中分离出作为中间体的烯胺酮。烯胺酮与其他酮烯醇化物的反应以良好的产率得到不对称的 1,5-二酮。
• Shape memory polymers
  申请人：Anthamatten Mitchell L.

  公开号：US20080177303A1

  公开（公告）日：2008-07-24

  The present disclosure relates to Shape Memory Polymers (SMP's) comprising function groups that allow the polymers to be elastically deformed, utilized in the elastically deformed state, and subsequently returned to the original polymorphic shape.

  本公开涉及形状记忆聚合物（SMP），其中包含允许聚合物弹性变形的功能基团，可在弹性变形状态下使用，并随后返回到原始的多态形状。
• ACTIVATED CYTOTOXIC COMPOUNDS FOR ATTACHMENT TO TARGETING MOLECULES FOR THE TREATMENT OF MAMMALIAN DISEASE CONDITIONS
  申请人：Fegley Glenn

  公开号：US20100022615A1

  公开（公告）日：2010-01-28

  Activated cytotoxic compounds are described for attachment to targeting molecules for the treatment of a mammalian disease condition which comprise, an activator, a spacer linker, a linker (e.g., self-immolative), and a cytotoxic drug selected from the group consisting of AMINO-SUBSTITUTED (E)-2,6-DIALKOXYSTYRYL 4-SUBSTITUTED BENZYLSULFONES, AMINO-AND-HYDROXY SUBSTITUTED STYRYLSULFONANILIDES, and SUBSTITUTED PHENOXY- AND PHENYLTHIO-STYRYLSULFONE DERIVATIVES. Activated cytotoxic compound attached to a targeting molecule are described wherein the targeting molecule is selected from the group consisting essentially of an antibody, a receptor, a ligand, a cytokine, a hormone, and a signal transduction molecule. The invention is further directed to a method of treatment of disease conditions.

  本发明涉及一种激活的细胞毒性化合物，用于附着于靶向分子治疗哺乳动物疾病状况，包括激活剂、间隔连接剂、连接剂（例如自解性连接剂）和从AMINO-SUBSTITUTED（E）-2,6-DIALKOXYSTYRYL 4-SUBSTITUTED BENZYLSULFONES、AMINO-AND-HYDROXY SUBSTITUTED STYRYLSULFONANILIDES和SUBSTITUTED PHENOXY-AND PHENYLTHIO-STYRYLSULFONE DERIVATIVES组成的细胞毒性药物。本发明还涉及附着于靶向分子的激活的细胞毒性化合物，其中靶向分子从抗体、受体、配体、细胞因子、激素和信号转导分子等组成的群体中选择。本发明进一步涉及一种治疗疾病状况的方法。
• Arylalkanes, arylalkenes and aryl-azaalkanes, pharmaceutical compositions containing these compounds and processes for preparing them
  申请人：RUDOLF Klaus

  公开号：US20070208036A1

  公开（公告）日：2007-09-06

  The present invention relates to compounds of general formula R-Z 1 -Z 2 -Z 3 -R  (I), wherein R, R 1 and Z 1 to Z 3 are defined as in claim 1 , the tautomers, the diastereomers, the enantiomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable pharmacological properties, particularly CGRP-antagonistic properties, pharmaceutical compositions containing these compounds, their use and processes for preparing them.

  本发明涉及一般式R-Z1-Z2-Z3-R(I)的化合物，其中R、R1和Z1至Z3如权利要求1所定义，其互变异构体、对映异构体、立体异构体、其混合物及其与无机或有机酸或碱的生理上可接受的盐，特别是具有有价值的药理学性质，特别是CGRP-拮抗性质的药物组合物，包含这些化合物，它们的用途和制备它们的过程。