2-[3-cyano-4-(2-furan-2-ylvinyl)-5,5-dimethyl-5H-furan-2-ylidene]malononitrile

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 2-[3-cyano-4-(2-furan-2-ylvinyl)-5,5-dimethyl-5H-furan-2-ylidene]malononitrile
• 英文别名: 2-{3-cyano-4-[2-(2-furyl)vinyl]-5,5-dimethyl-2,5-dihydrofuran-2-ylidene}malononitrile；2-{3-Cyano-4-[2-(2-furyl)vinyl]-5,5-dimethyl-2,5-dihydrofuran-2-ylidene}malononitrile；2-[3-cyano-4-[2-(furan-2-yl)ethenyl]-5,5-dimethylfuran-2-ylidene]propanedinitrile
• 化学式: C₁₆H₁₁N₃O₂
• 分子量: 277.282
• InChiKey: QVXOVAATJYDGDV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  93.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  糠醛 、 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 24.0h， 生成 2-[3-cyano-4-(2-furan-2-ylvinyl)-5,5-dimethyl-5H-furan-2-ylidene]malononitrile
  参考文献：
  名称：

  Synthesis of new unsaturated derivatives of functionally substituted 2-imino-2,5-dihydrofurans

  摘要：

  5,5-Substituted 2-imino-4-methyl-2,5-dihydrofuran-3-carbonitriles reacted with aromatic aldehydes to give the corresponding 5,5-substituted 2-imino-4-(2-R-vinyl)-2,5-dihydrofuran-3-carbonitriles. The latter were converted into hydrochlorides which were hydrolyzed to 3-cyano-4-(2-R-vinyl)-2,5-dihydrofuran-2-ones whose condensation with malononitrile afforded dicyanomethylidene derivatives.

  DOI：

  10.1134/s1070428011030183

文献信息

• RAPID AND EFFICIENT SYNTHESIS OF 2-[3-CYANO-4-(2-ARYLIDEN)-5, 5-DIMETHYL-5<i>H</i>-FURAN-2-YLIDENE]-MALONONITRILE UNDER FOCUSED MICROWAVE IRRADIATION
  作者：Didier Villemin、Liang Liao

  DOI：10.1081/scc-100104407

  日期：2001.1

  New biological potential furan-2-ylidenemalononitriles (IIIa-j) were synthetised efficiently by one-pot condensation under focused microwave from starting and easy available compounds.
• Synthesis of new unsaturated derivatives of functionally substituted 2-imino-2,5-dihydrofurans
  作者：A. A. Avetisyan、A. G. Alvandzhyan、K. S. Avetisyan

  DOI：10.1134/s1070428011030183

  日期：2011.3

  5,5-Substituted 2-imino-4-methyl-2,5-dihydrofuran-3-carbonitriles reacted with aromatic aldehydes to give the corresponding 5,5-substituted 2-imino-4-(2-R-vinyl)-2,5-dihydrofuran-3-carbonitriles. The latter were converted into hydrochlorides which were hydrolyzed to 3-cyano-4-(2-R-vinyl)-2,5-dihydrofuran-2-ones whose condensation with malononitrile afforded dicyanomethylidene derivatives.