2-formylcinnamic acid | 189356-79-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 2-formylcinnamic acid
• 英文别名: 2-Formyl Cinnamic Acid；3-(2-formylphenyl)prop-2-enoic acid
• CAS: 189356-79-4
• 化学式: C₁₀H₈O₃
• 分子量: 176.172
• InChiKey: ZIUMNQBNEUJSSL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-formylcinnamic acid 在 喹啉 、 铜 作用下， 生成 1-茚酮
  参考文献：
  名称：

  Decarboxylation of p- and o-Formylcinnamic Acids to p-Formylstyrene and 1-Indanone

  摘要：

  DOI：

  10.1021/ja01175a054
• 作为产物：
  描述：

  肉桂酸 、 邻苯二甲醛 在 乙酸酐 作用下， 生成 2-formylcinnamic acid
  参考文献：
  名称：

  Reaction of Naphthalene and Its Derivatives with Hydroxyl Radicals in the Gas Phase

  摘要：

  Naphthalene is the most abundant polycyclic aromatic hydrocarbon (PAH) found in urban air. It is reactive in the atmosphere under ambient conditions, its chief reaction partner being the hydroxyl radical, OH.. In this work, the reactions of OH. with naphthalene, 1- and 2-naphthol, and 1- and 2-nitronaphthalene were studied in a 9.4 m(3) smog chamber. Relative rates of reaction accorded well with previous studies and allowed estimates to be made of the atmospheric lifetimes of these compounds. Numerous oxidation products were identified, and mechanisms proposed for their formation were based on the further transformation of benzocyclohexadienyl radicals formed by addition of OH. to naphthalene. The naphthols and nitronaphthalenes were deduced not to be on the major reaction pathway to the more oxidized products. Because of the high reactivity of PAH in air, we suggest that priority be given to identifying and quantitating their reaction products, some of which may be relatively persistent air toxics.

  DOI：

  10.1021/es960813g

文献信息

• PROCESS FOR PREPARING LACIDIPINE
  申请人：Sajja Eswaraiah

  公开号：US20070043088A1

  公开（公告）日：2007-02-22

  A process for preparing lacidipine, comprising reacting a t-butoxy carbonyl methyl aryl phosphonium halide with o-phthalaldehyde, and further reacting a product comprising (E)-3-(2-formylphenyl)-2-propenoic acid, 1,1-dimethyl ethyl ester, without isolation, with ethyl-3-amino crotonate.

  一种制备拉西地平的方法，包括将叔丁氧羰基甲基芳基磷銨鹽与邻苯二甲醛反应，进一步将产物（E）-3-(2-甲酰基苯基)-2-丙烯酸，1,1-二甲基乙基酯与乙基-3-氨基巴豆酸酯在不经过分离的情况下反应。
• Asymmetric Photocatalysis by Intramolecular Hydrogen‐Atom Transfer in Photoexcited Catalyst–Substrate Complex
  作者：Chenhao Zhang、Shuming Chen、Chen‐Xi Ye、Klaus Harms、Lilu Zhang、K. N. Houk、Eric Meggers

  DOI：10.1002/anie.201905647

  日期：2019.10.7

  catalyzed by a bis-cyclometalated rhodium catalyst in the presence of visible light. Mechanistic experiments and DFT calculations support a mechanism in which a photoexcited catalyst/substrate complex triggers an intramolecular hydrogen-atom transfer followed by a highly stereocontrolled hetero-Diels-Alder reaction. In this reaction scheme, the rhodium catalyst fulfills multiple functions by 1) enabling

  3-（2-甲酰基苯基）-1-吡唑-1-基-丙烯酮经不对称光重排后，苯并[d]环丙烷[b]吡喃酮的ee值高达99％以上，并由双环金属化铑催化剂催化可见光的存在。机械实验和DFT计算支持一种机制，其中光激发的催化剂/底物复合物触发分子内氢原子转移，然后触发高度立体控制的杂Diels-Alder反应。在该反应方案中，铑催化剂具有多种功能，包括：1）使可见光π→π*激发与催化剂结合的烯酮基质，2）促进氢原子转移，以及3）为杂原子提供不对称感应-Diels-Alder反应。
• PROCESS FOR MAKING SALTS OF N-HYDROXY-3-[4-[[[2-(2-METHYL-1H-INDOL-3-YL)ETHYL]AMINO]METHYL]PHENYL]-2E-2-PROPENAMIDE
  申请人：Bajwa Joginder S.

  公开号：US20090187029A1

  公开（公告）日：2009-07-23

  Salts of N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide are prepared by various methods.

  通过各种方法制备N-羟基-3-[4-[[[2-(2-甲基-1H-吲哚-3-基)乙基]氨基]甲基]苯基]-2E-2-丙烯酰胺的盐。
• A facile and metal-free domino reaction of TsDAM and 2-alkenylarylaldehyde: An easy access to 8-hydroxy-2,8-dihydro indeno [2,1-<i>c</i>]pyrazoles
  作者：Gopathi Ramu、Bheeshma Geetanjali Kodiripaka、Kalakonda Raga Chaitanya、Bathini Nagendra Babu

  DOI：10.1039/d1ob00262g

  日期：——

  An efficient straightforward metal free domino approach was developed for the synthesis of various 8-hydroxy-2,8-dihydroindeno[2,1-c]pyrazoles via [3 + 2] cycloaddition of substituted alkenes and TsDAM (TosylDiAzoMethane). The salient features of this protocol include high efficiency, mild reaction conditions, greener solvent, metal-free reaction, scalability and broad substrate scope along with high

  开发了一种有效的直接无金属多米诺骨牌方法，用于通过取代烯烃和 TsDAM（TosylDiAzoMethane）的 [3 + 2] 环加成合成各种 8-羟基-2,8-二氢茚并[2,1- c ]吡唑。该协议的显着特点包括高效、温和的反应条件、更环保的溶剂、无金属反应、可扩展性和广泛的底物范围以及高区域选择性和产量。
• Process for modifying rubbers
  申请人：NIPPON ZEON CO., LTD.

  公开号：EP0087110A1

  公开（公告）日：1983-08-31

  A process for modifying a rubber, which comprises reacting a rubber having an unsaturated carbon linkage with an organic compound having a carboxyl group and an aldehyde group in the presence of an acid catalyst.

  一种改性橡胶的工艺，包括在酸催化剂存在下，使具有不饱和碳链的橡胶与具有羧基和醛基的有机化合物反应。